Results 181 to 190 of about 98,650 (241)

Demonstration of beat‐to‐beat, on‐demand ATP synthesis in ventricular myocytes reveals sex‐specific mitochondrial and cytosolic dynamics

The Journal of Physiology, EarlyView.
Abstract figure legend Beat‐locked mitochondrial ATP transients reveal modular, sex‐specific bioenergetic control during excitation–contraction coupling. A, each action potential activates L‐type CaV1.2 channels, producing a Ca2+ influx that triggers ryanodine receptors (RyR2) and elicits SR Ca2+ release.
Paula Rhana, Collin Matsumoto, L. Fernando Santana   +2 more
wiley   +1 more source

The Odyssey of macrophages. [PDF]

Biomed J
Kattner AA.
europepmc   +1 more source

Translocated Clam Retention and Effects on Ecosystem Functions Across a Gradient of Environmental Stress

New Zealand Journal of Marine and Freshwater Research, Volume 60, Issue 4, December 2026.
Estuarine ecosystems are experiencing increasing land‐derived stress, bringing sediments, excess nutrients and contaminants. Once degraded, disturbed soft sediment ecosystems can take years to recover because long‐lived, functionally important species that aid recovery are lost.
Natalie Prinz, Joanne I. Ellis, Lolita Rynkowski, Timothy Thomson, Rebecca V. Gladstone‐Gallagher, Candida Savage, Conrad A. Pilditch   +6 more
wiley   +1 more source

Exome sequencing early in outpatient evaluation in NCGENES 2: Changing the course of the diagnostic odyssey? [PDF]

HGG Adv
Roman TS, Gray SM, Sneddon TP, Foreman AKM, Lee K, Powell CM, Weck KE, Berg JS, Powell BC.   +8 more
europepmc   +1 more source

Pathogenic Variants in HEPACAM Alter Protein Localization and Interactome in Astrocytes of the Developing Mouse Cortex

Glia, Volume 74, Issue 11, November 2026.
Pathogenic variants alter hepaCAM protein distribution. Astrocyte‐specific hepaCAM TurboID reveals KCNQ2 as a new interaction partner. Pathogenic variants alter hepaCAM association with key transmembrane proteins. ABSTRACT Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare leukodystrophy characterized by early‐onset macrocephaly,
Robert W. Lewis, Breana C. Dogan, Amy L. Stanek, Elliot B. Evans, Madelyn G. Coble, Hayli E. Spence‐Osorio, Karen L. G. Farizatto, Angie L. Mordant, C. Allie Mills, Laura E. Herring, Katherine T. Baldwin   +10 more
wiley   +1 more source

The Long and Winding Road: Diagnostic Delays in Functional Seizures. [PDF]

Epilepsy Curr
Terman SW.
europepmc   +1 more source

Dichloroacetate Improves Animal Survival, Growth, Neuromuscular Activity, Mitochondrial Stress and Physiology, and Elevated Lactate in C. elegans pdha‐1 and dld‐1 RNAi Models of Pyruvate Dehydrogenase Complex Deficiency (PDCD)

Journal of Inherited Metabolic Disease, Volume 49, Issue 6, November 2026.
ABSTRACT Pyruvate dehydrogenase complex (PDHc) deficiency (PDCD) is a primary mitochondrial disorder characterized by neurodevelopmental disability, altered intermediary metabolism, and early mortality. Dichloroacetate (DCA), a pyruvate analog, activates PDHc and remains under clinical investigation for treatment of PDCD.
Cristina Remes, Neal D. Mathew, Victoria Miranda, Suraiya Haroon, Tyler O'Hara, Vernon E. Anderson, Manuela Lavorato, Kelsey Keith, Rui Xiao, Eiko Nakamaru‐Ogiso, Marni J. Falk   +10 more
wiley   +1 more source

On the measurement of glomerular filtration rate: An odyssey into the milieu intérieur

Experimental Physiology, EarlyView.
Anders Møller Greve, Anna Agnes Lytzen, Hrefna Sæunn Einarsdóttir, Michael Perch, Ronan M. G. Berg   +4 more
wiley   +1 more source

Dedifferentiation in endometrial cancer is associated with HLA‐I silencing that may be restored by IFN‐γ

The Journal of Pathology, Volume 270, Issue 3, Page 317-327, November 2026.
Abstract Dedifferentiated endometrial carcinoma occurs when a prognostically favorable low‐grade endometrial carcinoma transforms into a highly aggressive undifferentiated carcinoma following genomic inactivation of core SWItch/Sucrose Non‐Fermentable (SWI/SNF) complex protein(s).
Antonio De Leo, Madison Wickenberg, Marco Grillini, Camelia Alexandra Coadǎ, Pooja Praveen Kumar, Annie Tong, James Key, Hannah Kim, Felix Kommoss, Mark Carey, Yangxin Fu, Claudio Ceccarelli, Giovanni Tallini, Paul LaPointe, Martin Köbel, Cheng‐Han Lee   +15 more
wiley   +1 more source

Genomic Strategies in Pediatric Care: Addressing Rare Diseases in Children. [PDF]

Children (Basel)
Caelles-Gramunt N, Pijuan J.
europepmc   +1 more source