Oenothein B, a Bioactive Ellagitannin, Activates the Extracellular Signal-Regulated Kinase 2 Signaling Pathway in the Mouse Brain [PDF]
Plants, 2021 (1) Background: Oenothein B, a cyclic dimeric ellagitannin present in various medicinal plants, has been reported to exert diverse effects that are beneficial for the treatment and prevention of diseases, including cancer and infections.
Takashi Yoshida +2 more
exaly +4 more sources
Activation of Extracellular Signal-Regulated Kinase 2 and cAMP Response Element-Binding Protein in Cultured Neurons by the Macrocyclic Ellagitannin Oenothein B [PDF]
NeuroSci, 2022 (1) Background: The findings of our recent in vivo study indicated that the oral administration of oenothein B, a unique macrocyclic ellagitannin, activated extracellular signal-regulated kinase (ERK) 2 and cAMP response element-binding protein (CREB) in
Yoshiko Furukawa +2 more
exaly +4 more sources
Chemical and Biological Significance of Oenothein B and Related Ellagitannin Oligomers With Macrocyclic Structure [PDF]
Molecules, 2018 In 1990, Okuda et al. reported the first isolation and characterization of oenothein B, a unique ellagitannin dimer with a macrocyclic structure, from the Oenothera erythrosepala leaves.
Takashi Yoshida +2 more
exaly +4 more sources
Oenothein B in Eucalyptus Leaf Extract Suppresses Fructose Absorption in Caco-2 Cells [PDF]
Molecules, 2021 Inhibition of fructose absorption may suppress adiposity and adiposity-related diseases caused by fructose ingestion. Eucalyptus leaf extract (ELE) inhibits intestinal fructose absorption (but not glucose absorption); however, its active compound has not
Keiichiro Sugimoto +8 more
doaj +2 more sources
Oenothein B ameliorates hepatic injury in alcoholic liver disease mice by improving oxidative stress and inflammation and modulating the gut microbiota [PDF]
Frontiers in Nutrition, 2022 IntroductionAlcoholic liver disease (ALD) is a global health problem for which there is no current food and drug administration (FDA)-approved therapy. Oenothein B (OEB) is a macrocyclic dimer ellagic tannin that possesses abundant biological activities ...
Lu Xu +7 more
doaj +2 more sources
Oenothein B, a cyclic dimeric ellagitannin isolated from Epilobium angustifolium, enhances IFNγ production by lymphocytes. [PDF]
PLoS ONE, 2012 Oenothein B is a polyphenol isolated from Epilobium angustifolium and other plant sources, which has been reported to exhibit immunomodulatory properties.
Andrew G Ramstead +3 more
doaj +2 more sources
Effect of Fireweed (Chamerion angustifolium L.) Extracts and Oenothein B on Colon Cancer Cells: Impact of Leaf Fermentation on Viability and Mitochondrial Function [PDF]
MedicinaBackground and Objectives: Fireweed (Chamerion angustifolium L.) possesses antibacterial, antioxidant, anti-inflammatory, and anti-cancer properties. This study evaluated the effects of aqueous fireweed leaf extracts and their major compound, oenothein B,
Dovile Uogintaite +6 more
doaj +2 more sources
Efficacy of Willow Herb (Epilobium angustifolium L. and E. parviflorum Schreb.) Crude and Purified Extracts and Oenothein B Against Prostatic Pathogens [PDF]
AntibioticsBackground/Objectives: Plants species of the Epilobium genus are traditionally used to treat prostatitis and other urinary tract disorders and are particularly rich in ellagitannins and flavonol 3-O-glycosides.
Alexia Barbarossa +13 more
doaj +2 more sources
Phenological Variations in the Content of Polyphenols and Triterpenoids in Epilobium angustifolium Herb Originating from Ukraine [PDF]
Plants, 2023 The composition of secondary metabolites undergoes significant changes in plants depending on the growth phase and the influence of environmental factors.
Liudas Ivanauskas +6 more
doaj +2 more sources
From bioinformatics to bedside: PPBP drives glioblastoma progression under hypoxia via CXCR2/PI3K/Akt signaling and is targetable by Oenothein B [PDF]
Cancer Cell InternationalBackground Glioblastoma multiforme (GBM) is an aggressive brain cancer closely linked to hypoxic conditions and altered lactate metabolism. This study aims to investigate the prognostic factors of GBM by developing models that integrating hypoxia and ...
Xianwen Cao +7 more
doaj +2 more sources