Results 61 to 70 of about 272,337 (255)

The link between socioeconomic position, access to cycling infrastructure and cycling participation rates: An ecological study in Melbourne, Australia [PDF]

, 2014
Objective Promoting cycling has moved up the policy agenda in recent years, but debate still exists surrounding the role played by socioeconomic barriers to participation in low cycling countries.
Goodman, Anna, Pistoll, Chance
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Toolbox of Countermeasures for Rural Two-Lane Curves, June 2012 [PDF]

, 2012
The Federal Highway Administration (FHWA) estimates that 58 percent of roadway fatalities are lane departures, while 40 percent of fatalities are single-vehicle run-off-road (SVROR) crashes.

core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

State-of-the-art catalysts for clean fuel (methyl esters) production—a comprehensive review

JPhys Energy, 2022
There has been growing and recent interest in using non-edible feedstocks, such as waste animal fats, as an alternative to vegetable oils in biodiesel production to address the food versus fuel debate.
Farrukh Jamil, Muhammad Saleem, Obaid Ali Qamar, M Shahzad Khurram, Ala’a H Al-Muhtaseb, Abrar Inayat, Parveen Akhter, Murid Hussain, Sikander Rafiq, Hyunji Yim, Young-Kwon Park   +10 more
doaj   +1 more source

Design of an innovative off road hybrid vehicle by energy efficiency criteria [PDF]

, 2016
The environmental impact of road transport is significant because it is a major user of energy and the major user of the world's petroleum that is extracted every year.
Pascoa, Jose, Trancossi, Michele, Xisto, Carlos   +2 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Vaginal varicose veins in advanced pregnancy: a rare occurrence

Ibom Medical Journal
Varicose veins are common in pregnancy due to hormonal influences and increased venous pressure; however, vaginal varicosities are a rare and often underreported manifestation.
Dawud RM, Musa AD, Ja’afaru UH, Shehu AM, Baffah AM, Tiamiyu I, Musa AA, Halilu SD   +7 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Modeling Scavenging for a Hydraulic Free-Piston Engine [PDF]

, 2020
The hydraulic free-piston engine at the University of Minnesota offers a solution to improve the hydraulic efficiency and reduce emission output of off-road vehicles.
Davies, Nathan
core   +1 more source