KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Quantification and description of braking during mountain biking using a novel brake power meter : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Sport & Exercise at Massey University, Palmerston North, New Zealand [PDF]
, 2017 Olympic format cross country mountain biking is both physically and technically demanding. The demands of this cycling genre are in contrast to road cycling because of the demanding off-road terrain.
Miller, Matthew Curtis
core
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Pathogens, 2020 Globally, rotavirus group A (RVA) remains a major cause of severe childhood diarrhea, despite the use of vaccines in more than 100 countries. RVA sequencing for local outbreaks facilitates investigation into strain composition, origins, spread, and ...
Mike J. Mwanga +9 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Influence of Course Type on Upper Body Muscle Activity in Elite Cross-Country and Downhill Mountain Bikers During Off Road Downhill Cycling [PDF]
, 2012 This study aimed to investigate upper body muscle activity using surface electromyography (sEMG) in elite cross-country (XCO) and downhill (DH) cyclists during off road descending and the influence of man-made (MM) and natural terrain (NT) descents on ...
Atkins, Stephen +6 more
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Evaluation of off-road terrain with static stereo and monoscopic displays [PDF]
The National Aeronautics and Space Administration is currently funding research into the design of a Mars rover vehicle. This unmanned rover will be used to explore a number of scientific and geologic sites on the Martian surface. Since the rover can not
Hartley, Craig S., Yorchak, John P.
core +1 more source
Present state of research on narrow wheels: a prerequisite for traction studies on non-lug narrow wheels [PDF]
, 2011 The use of narrow wheels as traction members of simple agricultural machinery and equipment has been investigated. This equipment can be easily acquired and maintained by low income earners and the rural dwellers whose occupation is predominantly farming.
Ahmad, Desa +3 more
core +1 more source
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source