Results 161 to 170 of about 290,577 (296)

Reverse Genetics of Orthoflaviviruses: Strategies for Constructing Functional or Infectious cDNA. [PDF]

J Med Virol
Lee YM.
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Wirelessly controlled modular automatic chambers for greenhouse gas flux monitoring in natural and agricultural ecosystems. [PDF]

HardwareX
Mastepanov M.
europepmc   +1 more source

Confined site construction: a qualitative review of issues regarding health and safety on-site

, 2012
The construction industry is inherently hazardous, with a significant number of accidents and incidents occurring, particularly on confined construction sites.
JOHN SPILLANE (12351931), Lukumon O. Oyedele (12579622), Konanahalli, Ashwini, Ashwini Konanahalli (12579628), Spillane, John P., von Meding, Jason K., Oyedele, Lukumon O., Jason K. von Meding (12579625)   +7 more
core  

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

A low-cost triangular water-filled stand-off pad to improve needle visibility in ultrasound-guided procedures. [PDF]

CVIR Endovasc
Kumakura Y, Asao T, Sakai M, Kuriyama K, Okada T, Shiraishi T, Kimura A, Sano A, Shirabe K, Saeki H.   +9 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Deep learning-driven prediction of on-target activity, off-target risk, and repair outcomes in CRISPR/Cas9: current landscape and multi-scale perspectives. [PDF]

J Transl Med
Du W, Zhang T, Guo L, Zheng Y, Zhang H, Zhu X, Tang D, Hu H, Chen L, Liu C.   +9 more
europepmc   +1 more source

Using Prefabricated Wood Light-Frame in Multi-Storey and Non-Residential Construction Projects: Motivations and Barriers of Professionals in Quebec

BioResources
Despite prefabricated wood light-frame construction’s technical viability and ability to address labor shortages and industry productivity issues, its adoption remains limited.
Baptiste Giorgio, Pierre Blanchet, Aline Barlet, Adrien Gaudelas   +3 more
doaj  

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source