High-throughput editing boosts the construction of next-generation microbial cell factories. [PDF]
Sun X +7 more
europepmc +1 more source
How phagocytic cells kill bacteria: Lessons from a professional killer
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley +1 more source
Structural Biology Resources at an Upgrading Synchrotron Advanced Light Source. [PDF]
Ralston CY, Hura GL, Adams PD.
europepmc +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
Workforce Safety Vulnerabilities in Pakistan's Construction Sector. [PDF]
Umair M, Yousuf MU.
europepmc +1 more source
Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson +2 more
wiley +1 more source
Experimental study on the seismic performance of thin-walled CFST superimposed shear walls with different column widths. [PDF]
Gao M +5 more
europepmc +1 more source
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
Shared drone route scheduling optimization. [PDF]
Hong C, Yan Y, Lian Z, Li X.
europepmc +1 more source
Implementation of BIM for Off-Site Manufacturing in Construction Industry
Building Information Modeling (BIM) is a new developing technology and a modern approach that could achieve a specific position in construction in recent years due to its abilities and capabilities. Since, this technology and new approach is able to create a virtual model of building with details and all components, the authority of stakeholder’s ...
openaire +1 more source

