Results 51 to 60 of about 290,577 (296)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Engineering ProceedingsKuwait faces a pressing challenge in expanding its existing buildings to meet growing demands. The rising popularity of modular construction systems, with their off-site construction approach, offers promising solutions. In this research, we explored the
Areej AlBanwan +2 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
BuildingsStakeholder management is a crucial component in the implementation of off-site construction (OSC) projects, while stakeholder mapping serves as a practical technique to facilitate an in-depth understanding of different project stakeholders.
Qing Zhu +5 more
doaj +1 more source
Optimization Models for Reducing Off-Cuts of Raw Materials in Construction Site
Mathematics, 2022 More than ten billion tons of construction waste are generated every year in the world. The large volume of construction waste not only increases costs for contractors, but also poses a threat to the environment.
Haoqing Wang, Wen Yi
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Flow and Resource Efficiency Measurement Method in Off-Site Production
, 2017 Although the focus remains primarily on high resource efficiency, the significance of flow efficiency in construction is continuously increasing. Flow and resource efficiency describe two competing target viewpoints, which focus on reducing non-value ...
Helena Lidelöw +5 more
core +1 more source
The impact of off-site construction on firms’ sustainable performance [PDF]
, 2022 Off-site construction (OSC) offers an innovative building solution to produce and assemble construction components in factories. It has been claimed to have major contributions in reducing production costs, complexity and improving quality.
Abualqumboz, Moheeb +2 more
core
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source