Results 71 to 80 of about 290,577 (296)
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
, 2007 Off-site Manufacture (OSM) has long been recognised, both in Australia and internationally,\ud as offering numerous benefits to all parties in the construction process. More importantly, it is\ud recognised as a key vehicle for driving improvement within
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FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Off-site Manufacture in Australia : Current State and Future Directions
, 2007 Off-site manufacture (OSM) offers numerous benefits to all parties in the construction process. The\ud uptake of OSM in Australia has, however, been limited. This limited uptake corresponds to similar trends\ud in the UK and US, although the level of OSM
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Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Comparison of OSC (Off-Site Construction) Level Measurement Methods
BuildingsStudies have shown that the implementation of OSC (off-site construction) is beneficial. However, most studies have relied on simulated project data to forecast the potential advantages of OSC, often using surveys or expert consultations as their primary
Chulwoo Im +3 more
doaj +1 more source
Off-site and modern methods of timber construction a sustainable approach.
, 2010 Many prefer the versatility of timber frame for panelised, volumetric and hybrid 'built offsite' systems. Other suitable formats include timber post and beam, 'massive' construction using cross-laminated timber, and structural insulated panel systems ...
Hairstans, Robert
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Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Modular Construction to Support Airport Sustainability at US Airports
Future TransportationThis paper explores how modular construction can enhance airport sustainability, highlighting example applications at US airports. Whereas traditional construction builds sequentially on-site, modular construction (also known as prefabricated, off-site ...
Sarah Hubbard
doaj +1 more source