Results 91 to 100 of about 290,577 (296)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
BuildingsTo continuously improve the efficiency of the construction project delivery process, various innovative methods and technologies have been developed and adopted in the past decades.
Lijun Liu +3 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Off-Site Automation and Prefabrication in Construction: A Review
The construction sector is steadily moving toward innovative practices like off-site automation and prefabrication to overcome persistent issues such as delays, labor shortages, and quality variations common in traditional on-site construction. In this approach, structural components are produced in controlled factory settings using robotic systems ...
Ravikumar Shantibhai Parmar +3 more
openaire +1 more source
A process-oriented approach to supporting Off-site Manufacture in construction projects
, 2013 It is well-known that the use of off-site manufacture (OSM) techniques can assist in timely completion of a construction project though the utilisation of such techniques may have other disadvantages.
Kenley, Russell +5 more
core
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Developments in the Built EnvironmentEffectively monitoring and analyzing on-site module installation for modular integrated construction (MiC) is essential to properly coordinating the MiC process.
Jongyeon Baek, Daeho Kim, Byungjoo Choi
doaj +1 more source
Accounting for transport times in planning off-site shipment of construction materials
, 2016 © 2015 American Society of Civil Engineers. Off-site transportation of construction materials is planned commonly by considering the transportation costs as the dominant decision variable.
Ahmadian, FFA +3 more
core +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source