Results 111 to 120 of about 7,149,350 (256)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
, 2011 Copyright information:Taken from "Scaling up kangaroo mother care in South Africa: 'on-site' versus 'off-site' educational facilitation"http://www.human-resources-health.com/content/6/1/13Human Resources for Health 2008;6():13-13.Published online 23 Jul ...
Elise van Rooyen (52905) +2 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Barriers and drivers for increased use of off-site bridge construction in Sweden
, 2012 There is great pressure to change the civil engineering industry in Sweden, which is said not to follow efficiency growth other manufacturing sectors are achieving.
Larsson, Johan, Simonsson, Peter
core +2 more sources
Discover Civil EngineeringThe Nigerian construction industry is largely based on linear and unsustainable approaches, which have resulted in housing deficits, affordability problems and environmental degradation.
Olayinka Omoboye +3 more
doaj +1 more source
Modelling construction business performance [PDF]
, 2008 Searching academic databases for records on ‘business failure’, ‘business distress’ or ‘bankruptcy’\ud yields a large body of studies on qualitative, empirical, theoretical and simulation aspects.
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Revisiting the Three Peculiarities of Production in Construction [PDF]
Compared to many other industries, construction is a specific type of project industry with certain pe- culiarities influencing the characteristics of constructed products, ways of production, and the indus- try itself.
Koskela, Lauri, Vrijhoef, Ruben
core +3 more sources