Results 101 to 110 of about 290,577 (296)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Construction in Imperial Rome: organisation, logistics, and daily life on building sites
Arqueología de la ArquitecturaThis article investigates the phenomenon of the building site in ancient Rome, drawing on ancient literary sources, legal texts, as well as epigraphic, iconographic, and archaeological evidence.
Fabrizio Sommaini
doaj +1 more source
Value-based modelling: an Australian case of off-site manufactured buildings
, 2018 Benefits to the construction industry through the use of off-site manufactured (OSM) buildings are well documented. However, and like most innovations, the uptake of OSM has been rather slow.
Sahin, Oz, Mohamed, Sherif, Miller, Dane
core +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
A Research Roadmap for Off-Site Construction: Automation and Robotics
, 2019 The development of a research roadmap was undertaken to further the activities of a joint industry-university-government initiative in off-site construction research in Canada.
Rankin, Jeff, Bowmaster, Jeremy
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Defects in off-site construction : timber module prefabrication
, 2009 The construction industry is based on craftsmanship. Quality control and assurance procedures applied in manufacturing cannot usually be readily applied in construction, where there are higher degrees of uniqueness in each project.
Meiling, John,, Johnsson, Helena,
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Strengthening Sustainability Rating Credit for Off-Site Construction
Modular and Offsite Construction (MOC) Summit Proceedings, 2016 Off-site construction has inherent advantages over conventional construction in terms of sustainability that extend well beyond lower construction site waste, yet the common building sustainability rating systems in the U.S. and Canada provide little or no credits to reflect prefabricationäó»s sustainability-promoting characteristics. As project owners
openaire +2 more sources
Barriers and drivers for increased use of off-site bridge construction in Sweden
, 2012 There is great pressure to change the civil engineering industry in Sweden, which is said not to follow efficiency growth other manufacturing sectors are achieving.
Larsson, Johan, Simonsson, Peter
core