Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
The energy and time saving coordinated control methods of CO2, VOCs, and PM2.5 in office buildings. [PDF]
PLoS One, 2022 Wu X +5 more
europepmc +1 more source
The thermal simulation of an office building implementing a new behavioural algorithm for window opening and the use of ceiling fans [PDF]
, 2009 This investigation of the window opening data from extensive field surveys in UK office buildings investigates 1) how people control the indoor environment by opening windows, 2) the cooling potential of opening windows, and 3) the use of an “adaptive ...
Clarke, Joseph Andrew +4 more
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Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Analysis of the impact of a fresh air system on the indoor environment in office buildings. [PDF]
Sustain Cities Soc, 2022 Niu RP, Chen X, Liu H.
europepmc +1 more source
The effectiveness of the direct sales comparison approach to office appraisal in Singapore [PDF]
, 1996 The skyline of Singapore’s Central Business District (CBD) reflects the prestige and multitude of office buildings in the city state. Investment in CBD office buildings can amount to billions of Singapore dollars.
Addae-Dapaah, K
core
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Optimizing the use of acoustic materials in office buildings. [PDF]
Sci Rep, 2021 AlOmani A, El-Rayes K, Altuwaim A.
europepmc +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Hot water plumbing in residences and office buildings have distinctive risk of Legionella pneumophila contamination. [PDF]
Int J Hyg Environ Health, 2022 Donohue MJ +3 more
europepmc +1 more source