Results 141 to 150 of about 660,630 (306)
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
University Unions Graphic Design Office Student Work 1997
, 2011 Graphic design work produced by UUGDO student designers in 1996-1997http://deepblue.lib.umich.edu/bitstream/2027.42/87937/1/FY1997 ...
University Unions Graphic Design Office, University of Michigan
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Experiments with a cameraphone-aided design (CpAD) system [PDF]
, 2005 Paper-based freehand sketching is still widely used by practicing designers to externalise their early form design solutions. Existing Computer-Aided Design (CAD) systems are mostly used in later design stages, as their user-interface lacks the ...
Farrugia, Philip +4 more
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Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Elevation Design Guidelines for Historic Properties
, 2019 These Elevation Design Guidelines for Historic Properties were prepared for the New Jersey Historic Preservation Office, Department of Environmental Protection as a companion to the Flood Mitigation Guide for Historic Properties.
Preservation Design Partnership, LLC +1 more
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Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Value engineering review report
, 2008 "Prepared for Connecticut Department of Transportation, Office of Rail and State Design-Facilities ...; prepared by Vanasse Hangen Brustlin, Inc. ..."-Cover.; "Final report, February 2008."; Accompanied by "VE proposals incorporated into design and ...
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Stanford’s ME310 Course as an Evolution of Engineering Design [PDF]
, 2009 Organised by: Cranfield UniversityME310 is a radical course that has been taught at Stanford University since 1967. The year-long course is a graduate level sequence in which student teams work on complex engineering projects sponsored by industry ...
Leifer, L., Carleton, T.
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source