Results 131 to 140 of about 17,119,270 (336)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Modelling the relationship between planning, control, perception and execution behaviours in interactive worksystems [PDF]
, 1992 This paper presents a model of planning carried out by interactive worksystems which attempts: 1. To describe the relationship between planning, control, perception and execution behaviours; 2.
Hill, B +3 more
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Integratıng bıophılıc desıgn elements ınto offıce desıgns
Ain Shams Engineering JournalBiophilic design, in the context of modern interior spaces, focuses on incorporating natural elements and materials to counter the growing disconnect between people and nature. It aims to enhance human well-being, particularly within office environments,
Ahenk Karci Demirkol +1 more
doaj +1 more source
Novel Approach to Design Ultra Wideband Microwave Amplifiers: Normalized Gain Function Method [PDF]
, 2013 In this work, we propose a novel approach called as “Normalized Gain Function (NGF) method” to design low/medium power single stage ultra wide band microwave amplifiers based on linear S parameters of the active device.
Kopru, R., Kuntman, H., Yarman, B. S.
core +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Correction: The work environment pilot: An experiment to determine the optimal office design for a technology company. [PDF]
PLoS One, 2020 Pitchforth J +3 more
europepmc +1 more source
Building simulation for energy efficient solar shading [PDF]
, 2008 The external horizontal shading device is an important climatic design element in the tropical climate. According to the revi ew, little is known about the in fluence of external horizontal shading device on reducing the ...
Ossen, Dilshan Remaz
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source