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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Under the EU’s multilingualism policy, its 24 languages have equal status as both official and working languages. However, in fact, most of the EU’s day-to-day work is now conducted in English. In contrast, most EU staff writing in English are not native
Jeremy Gardner
doaj +1 more source
Structural biology of ferritin nanocages
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Ever Closer Union or Babylonian Discord? The Official-language Problem in the European Union [PDF]
Extensive multilingualism is one of the most important and fundamental principles of the European Union. However, a large number of official languages (currently 23) hinders communication and imposes substantial financial and legal costs.
Jan Fidrmuc +2 more
core +3 more sources
Catalan, a touchstone for European linguistic diversity
The EU is about to enter into an expansion that will mean the incorporation of 10 new official languages, many of which have a lesser demographic dimension and cultural vitality than Catalan. This article comments that the current situation of Catalan in
Isidor Marí Mayans
doaj
Tłumaczenie prawa unijnego a centralne pojęcia przekładoznawstwa
Translation of EU law versus the central concepts of Translation Studies The objective of the paper was: (1) to analyse EU translation in light of central concepts of Translation Studies, and (2) to attempt a synthesis of numerous studies on EU ...
Łucja Biel
doaj +1 more source
Does Brexit spell the end for English as the lingua franca of the EU? [PDF]
The UK is not the only English speaking EU state, but when Ireland and Malta both joined the EU they opted to put forward Irish and Maltese as their official languages.
Vítores, David Fernández
core
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Multilingual Law and Judicial Interpretation in the EU
The purpose of this article is to assess how multilingualism affects judicial interpretation of EU law. In the EU, the European Court of Justice is in the position of having the final say on what EU norms mean.
Tamara Ćapeta
doaj +1 more source

