Results 211 to 220 of about 911,118 (353)

Sex as a biological variable in nonclinical studies: Bridging scientific rigor, animal welfare, and regulatory expectations

Animal Models and Experimental Medicine, EarlyView.
Sex as a biological variable (SABV) is a critical determinant of pharmacokinetics, pharmacodynamics, and toxicity in nonclinical studies. This review highlights how inappropriate neglect of sex differences compromises animal welfare, scientific reproducibility, and regulatory compliance.
Kenta Onuma, Masaki Watanabe, Nobuya Sasaki   +2 more
wiley   +1 more source

Abnormal intestinal microbial colonization in prenatally stressed offspring is related to lung and intestinal cytokine expression. [PDF]

Front Microbiol
Duff AF, Bailey MT.
europepmc   +1 more source

Cytogenetic Analysis of Transgenic Rabbit Offspring Resulting from the F4 Generations

, 2008
Karima Gh. M. Mahmoud, Jozef Curlei, V. Parkányi, Peter Chrenek   +3 more
openalex   +2 more sources

A novel mouse model of endometriosis: Simulating the recurrent hemorrhagic microenvironment of clinical lesions

Animal Models and Experimental Medicine, EarlyView.
To address the limitations of existing models, this study innovatively established a mouse model of endometriosis (EMs) capable of mimicking cyclic bleeding. Our results confirmed that this model recapitulates the complete pathological progression from ectopic lesion establishment to systemic responses, exhibiting superior clinical relevance compared ...
Yu Zhuang, Yan Zan, Tiantian Ma, Xiaoquan Huang, Junwei Li, Liangjun Xia, Yuping Sa, Youbing Xia   +7 more
wiley   +1 more source

Lactational Western-Style Fat Exposure in Mice Programs Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Male Offspring. [PDF]

Mol Nutr Food Res
Zhao AY, Sun H, Yan L, Shiyanbola O, Bridges D, Gregg B.   +5 more
europepmc   +1 more source

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source

Offspring long-term infectious morbidity following pregnancies with cervical cerclage. [PDF]

Arch Gynecol Obstet
Snir A, Schwarzman P, Wainstock T, Sheiner E.   +3 more
europepmc   +1 more source

Advances and perspectives in animal models of human hepatitis A virus

Animal Models and Experimental Medicine, EarlyView.
Following HAV infection, humans, non‐human primates, and Ifnar1−/− mice develop characteristic manifestations of hepatitis A, including fecal viral shedding, elevated serum ALT levels, and inflammatory cell infiltration in the liver. In contrast, HAV‐infected human liver chimeric mice exhibit fecal viral shedding but do not develop clinical features of
Jian Li, Pei‐Yu Jiang, Hui Zhao, Cheng‐Feng Qin   +3 more
wiley   +1 more source

Inheritable Epigenetic Memory Induced by Parental Salt Stress Influences Transgenerational Plasticity of <i>Phragmites australis</i>. [PDF]

Ecol Evol
Chen YH, Wang CL, Meng JQ, Liu YF, Fang T, Zhu YJ, Luo FL.   +6 more
europepmc   +1 more source

Effects of maternal feed restriction during the last third of pregnancy in goats on feeding behaviour development in offspring

, 2010
Bérengère Laporte Broux
openalex   +1 more source