Results 91 to 100 of about 16,974 (127)
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Development of Resistance to Ofloxacin
Drugs, 1987As a member of the 4-quinolone group of antibacterial agents, ofloxacin shares the almost unique feature of being exempt from plasmid-borne resistance in either Gram-negative or Gram-positive bacteria. In the light of this feature, the development of resistance mediated through chromosomal mutation has been carefully studied, particularly the processes
M. Odell, G. C. Crumplin
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Bactrecidal mechanisms of ofloxacin
Journal of Antimicrobial Chemotherapy, 1988Ciprofloxacin and ofloxacin are known to exert a second bactericidal mechanism (termed B) against Escherichia coli which functions even when protein synthesis is inhibited by chloramphenicol or when RNA synthesis is inhibited by rifampicin. However, the bactericidal activity of ciprofloxacin against a coagulase-negative staphylococcus (Staphylococcus ...
J. T. Smith, C S Lewin
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Application of Ofloxacin in Gynaecology
Drugs, 1987Most infections in obstetrics and gynaecology are ascendant infections from the vaginal area or from the lower urinary tract. Apart from specific pathogens, like gonococci and Chlamydia trachomatis, many different bacteria may be involved and can often be detected in high concentrations, by the use of suitable methods, especially in soft tissue ...
Norbert Weiss +3 more
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Annals of Internal Medicine, 1988
Excerpt Ofloxacin, a new 4-quinolone derivative that can be administered orally, has a broad spectrum of activity against many important aerobic and anaerobic pathogens.
Jonathan Leor, Shlomo Matetzki
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Excerpt Ofloxacin, a new 4-quinolone derivative that can be administered orally, has a broad spectrum of activity against many important aerobic and anaerobic pathogens.
Jonathan Leor, Shlomo Matetzki
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Psychotoxic Effects of Ofloxacin
Pharmacopsychiatry, 1989Two cases of organic psychosis, induced by the new chemotherapeutic agent ofloxacin (Tarivid), are described. According to DSM-III-R and ICD 10 (draft, 1987) both cases present as different, yet well-defined diagnostic categories: the new diagnostic systems appear to be superior and markedly more differentiated than ICD-9, since they provide a more ...
W Zieglgänsberger +4 more
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Annals of Pharmacotherapy, 1997
OBJECTIVE: To describe a possible case of ofloxacin-induced generalized tonic—clonic seizure. Although the etiology is unknown, ofloxacin most likely precipitated this patient's seizure threshold because of sepsis or secondary to drug accumulation due to the patient's compromised renal function.
Jeremy K Hon +2 more
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OBJECTIVE: To describe a possible case of ofloxacin-induced generalized tonic—clonic seizure. Although the etiology is unknown, ofloxacin most likely precipitated this patient's seizure threshold because of sepsis or secondary to drug accumulation due to the patient's compromised renal function.
Jeremy K Hon +2 more
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Ofloxacin Clinical Pharmacokinetics
Clinical Pharmacokinetics, 1992Ofloxacin is a new fluoroquinolone with a spectrum of activity similar to other fluoroquinolones with activity which includes Chlamydia trachomatis, Mycobacterium spp., Mycoplasma spp. and Legionella pneumophila. Through its additional mechanisms of action, ofloxacin may be less susceptible to the development of resistance from Staphylococcus aureus ...
Elaine M. Bailey +5 more
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Resistance studies with ofloxacin
Journal of Antimicrobial Chemotherapy, 1988The selection of ofloxacin-resistant mutants from susceptible wild-type bacterial populations was investigated by three methods. Resistant mutants selected from populations of Escherichia coli (NCTC 10418) and Staphylococcus aureus (NCTC 6571) by single-step passage at either four or eight times the MIC occurred at a frequency of less than 1 x 10(-10).
Foxall Pa +5 more
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Ofloxacin, a Bactericidal Antibacterial
Chemotherapy, 1991Ofloxacin, like other 4-quinolones, is unusual among front line drugs available to treat bacterial infections since it affects bacterial DNA synthesis, rather than cell wall or protein synthesis. The 4-quinolones are also unusual because even for serious infections they can be given orally.
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Drugs, 1987
The in vitro activities of ofloxacin, desmethyl ofloxacin and ofloxacin N-oxide were determined and a specific high performance liquid chromatography (HPLC) assay for these 3 compounds was devised as part of a study of the pharmacokinetics of ofloxacin and its metabolites in patients with impaired renal function.
Andrew M. Lovering +4 more
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The in vitro activities of ofloxacin, desmethyl ofloxacin and ofloxacin N-oxide were determined and a specific high performance liquid chromatography (HPLC) assay for these 3 compounds was devised as part of a study of the pharmacokinetics of ofloxacin and its metabolites in patients with impaired renal function.
Andrew M. Lovering +4 more
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