Results 91 to 100 of about 28,063 (214)

Phosphatidic Acid‐TRIM59‐Olig2 Signaling Couples Metabolic Dysfunction to Myelination Failure in PWMI

Advanced Science, Volume 13, Issue 25, 4 May 2026.
PA accumulates after hypoxic‐ischemic injury and stabilizes the E3 ligase TRIM59 in OPCs. Stabilized TRIM59 enhances ubiquitination and degradation of Olig2, blocking differentiation and causing hypomyelination in PWMI. Modulating PA synthesis restores Olig2 levels, improves myelination, and ameliorates behavioral deficits, defining a metabolically ...
Xinyu Li, Yanan Liu, Meng Zhang, Yiwei Liu, Meiting Liu, Kaishen Zhu, Zhian Liu, Chao Ren, Ruiqin Yao   +8 more
wiley   +1 more source

Using mixed methods to track the growth of the Web: tracing open government data initiatives

, 2012
In recent years, there have been a rising number of Open Government Data (OGD) initiatives; a political, social and technical movement armed with a common goal of publishing government data in open, re-usable formats in order to improve citizen-to ...
Carr, Leslie, Halford, Susan, Pope, Catherine, Tinati, Ramine   +3 more
core   +1 more source

Mitochondria and neuroprotection in stroke: Cationic arginine-rich peptides (CARPs) as a novel class of mitochondria-targeted neuroprotective therapeutics [PDF]

, 2018
Stroke is the second leading cause of death globally and represents a major cause of devastating long-term disability. Despite sustained efforts to develop clinically effective neuroprotective therapies, presently there is no clinically available ...
Anderton, Ryan S, Knuckey, Neville W, MacDougall, Gabriella, Mastaglia, Frank L, Meloni, Bruno P   +4 more
core   +1 more source

RVG‐Modified BMSCs‐Derived Small Extracellular Vesicles Loaded With miR‐21 Alleviate Neuronal Injury Resulted From Excessive Autophagy via Targeting PTEN/Akt/mTOR Pathway After Cerebral Ischaemia

Journal of Extracellular Vesicles, Volume 15, Issue 5, May 2026.
Bioengineered brain targeting RVG‐modified BMSCs‐derived small extracellular vesicles loaded with miR‐21 alleviate excessive autophagic neuronal injury after cerebral ischaemia via PTEN/Akt/mTOR pathway. ABSTRACT Ischaemic stroke (IS) leads to tragic disability and high adult mortality, while there are limited therapeutic measures for it.
Yiyang Li, Jiacheng Hu, Jinfen Chen, Manfei Zhou, Mingchun Liao, Yayue Yang, Jiahao Zhou, Yan Han, Bin Wang, Yonghua Zhao   +9 more
wiley   +1 more source

Sedation for Gastrointestinal Endoscopic Procedures in the Elderly: Getting Safer but Still Not Nearly Safe Enough [PDF]

, 2006
Previously published UK reports showed that excessively large doses of benzodiazepines and opiates were being commonly used to sedate elderly patients for gastrointestinal (GI) endoscopy. This unsafe practice has lead to avoidable morbidity and mortality.
Bell, G. D., Bowles, J, De La Iglesia, Beatriz, Gray, A, Lord, David, Quine, A, Rayward-Smith, Vic, Reynolds, Alan, Romaya, C   +8 more
core  

Pantothenic Acid Protects Neurons After Ischemic Stroke by Targeting ID3 to Restore Action Potential Amplitude

Journal of Neuroscience Research, Volume 104, Issue 5, May 2026.
Ischemic stroke reduces ID3 expression and impairs neuronal action potential amplitude and frequency. Pantothenic acid (PA) targets and upregulates ID3, restoring amplitude but not frequency. The PA‐ID3‐amplitude axis represents a potential neuroprotective strategy.
Hongqiao Chen, Mingli Chen, Lian Meng, Xing Wei, Yan Qin, Zhumei Bi   +5 more
wiley   +1 more source

Role of COL1A1 and CD44 in Modulating JAK1/STAT3‐Mediated Autophagy for Spinal Cord Injury Recovery

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 5, May 2026.
ABSTRACT Spinal cord injury (SCI) is a severe trauma to the central nervous system that often leads to motor and sensory dysfunction in patients, severely affecting their quality of life. Autophagy plays a role in the pathological process of SCI, but the specific mechanism of autophagy in this case is unknown.
Chun‐Lei Li, Qian Zhang, Li Fang, Ling‐Yun Zhou   +3 more
wiley   +1 more source

Selenocysteine antagonizes oxygen glucose deprivation-induced damage to hippocampal neurons

Neural Regeneration Research, 2018
Designing and/or searching for novel antioxidants against oxygen glucose deprivation (OGD)-induced oxidative damage represents an effective strategy for the treatment of human ischemic stroke.
Xian-Jun Wang, Mei-Hong Wang, Xiao-Ting Fu, Ya-Jun Hou, Wang Chen, Da-Chen Tian, Su-Yun Bai, Xiao-Yan Fu   +7 more
doaj   +1 more source

Systemic Therapy for Advanced Hepatocellular Carcinoma in 2026: Current Standard‐of‐Care and Emerging Therapeutic Strategies

Journal of Gastroenterology and Hepatology, Volume 41, Issue 5, Page 1436-1445, May 2026.
ABSTRACT Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, accounting for up to 80% of all cases. Most patients present at an advanced stage and are unsuitable for curative treatments. In the past 5 years, immunotherapy combination has superseded tyrosine kinase inhibitors (TKI) as the standard first‐line therapy for ...
Landon L. Chan, Kallista O. K. Chan, Stephen L. Chan   +2 more
wiley   +1 more source

Insights Into Remote Ischemic Conditioning miRNA Effects on Brain Endothelial Cells During Ischemia–Reperfusion

Microcirculation, Volume 33, Issue 4, May 2026.
ABSTRACT Objective Acute ischemic stroke (AIS) is one of the leading causes of death and disabilities, and as such, it is of utmost importance to identify novel treatment options. Remote ischemic conditioning (RIC) is a promising non‐invasive treatment that is thought to activate the body's own protective mechanisms against damaging ischemia.
Katrine Tang Stenz, Jesper Just, Zenghui Huang, Thomas Ravn Lassen, Kristian Vissing, Xiu‐Jie Wang, Kim Ryun Drasbek   +6 more
wiley   +1 more source