Results 11 to 20 of about 22,450 (179)

Evaluation of the efficacy of optical genome mapping in prenatal diagnosis: a retrospective cohort study [PDF]

Journal of Translational Medicine
Background Optical genome mapping (OGM) is an emerging cytogenetic method for concurrently detecting structural variants (SVs) and copy number variants (CNVs). However, its clinical application in prenatal diagnosis remains underexplored.
Kaili Yin, Yan Lü, Hanzhe Zhang, Mengmeng Li, Jiazhen Chang, Xueting Yang, Qingwei Qi, Xiya Zhou, Jiangshan Guo, Yaru Wang, Cuixia Wang, Wei Li, Na Hao, Yulin Jiang   +13 more
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OGM Information des consommateurs et séparation des filières OGM/non-OGM [PDF]

Oléagineux, Corps gras, Lipides, 2000
Un des problèmes au centre de la controverse sur l’utilisation des organismes génétiquement modifiés (OGM) dans l’agriculture et l’alimentation est celui de l’information des citoyens et des consommateurs.
Valceschini Egizio
doaj   +2 more sources

Optical genome mapping in myelofibrosis: enhancing prognostic accuracy through high-resolution genomic profiling [PDF]

Blood Advances
: Accurate genomic stratification is essential for guiding therapeutic decisions in myelofibrosis (MF), particularly regarding allogeneic stem cell transplant.
Álvaro Díaz-González, Elvira Mora, Marta Garrote, Gonzalo Carreño-Tarragona, Marta Salido, Irene Pastor-Galán, Ruth Stuckey, Adela Cisneros, José Antonio Domingo-Monfort, Nerea Uresandi-Iruin, Nagore Argoitia-Ituarte, Gayane Avetisyan, Cristian García-Ruiz, Neus Torres-Hernández, Santiago Furió, Eduardo Arellano-Rodrigo, Noemí Álvarez, Patricia Vélez, Eva Villamón, Adrián Segura-Díaz, Rosa Ayala, Blanca Espinet, Alberto Álvarez-Larrán, Juan Carlos Hernández-Boluda, Esperanza Such   +24 more
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DOGMA: de novo assembly of densely labelled optical DNA maps using a matrix profile approach. [PDF]

PLoS ONE
In optical genome mapping (OGM), large numbers of individual DNA maps-sequence-specific data series along single DNA molecules-are produced. Such individual maps have to be stitched together in a process called de novo OGM assembly in order to create ...
Albertas Dvirnas, Luis Mario Leal-Garza, Zahra Abbaspour, Erik Fröbrant, Karolin Frykholm, Marie Wrande, Linus Sandegren, Fredrik Westerlund, Tobias Ambjörnsson   +8 more
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A methodological study on the process of prenatal optical genome mapping: focusing on cell culture and quality control [PDF]

Molecular Cytogenetics
Background Optical genome mapping (OGM) has demonstrated significant potential in detecting structural variations (SVs) and has been comprehensively evaluated both retrospectively and prospectively in prenatal diagnosis.
Xueting Yang, Kaili Yin, Mengmeng Li, Jing Zhou, Hanzhe Zhang, Qingwei Qi, Xiya Zhou, Yulin Jiang, Yaru Wang, Na Hao   +9 more
doaj   +2 more sources

Optical genome mapping as a diagnostic tool for unsolved balanced translocations in couples with adverse pregnancy outcomes: a case series [PDF]

European Journal of Medical Research
Objective Cryptic balanced translocations are a challenging diagnostic dilemma in conventional cytogenetics. This study aimed to evaluate the utility of optical genome mapping (OGM), an emerging technology for detecting structural variations, in ...
Xiaohuan Zhang, Yingnan Liao, Li Cao, He Lin, Xuemei Wu, Ling Liao, Chang Tan, Shi Ma, Guo Huang   +8 more
doaj   +2 more sources

Pilot evaluation of optical genome mapping in chronic lymphocytic leukemia: complementing FISH analysis [PDF]

BMC Cancer
Background The clinical heterogeneity observed in chronic lymphocytic leukemia (CLL) is largely attributed to diverse underlying genomic alterations. Fluorescence in situ hybridization (FISH) remains the standard cytogenetic technique but is limited to ...
Simge Erdem, Ayşe Gül Bayrak Tokaç, Aynur Aday, Dilan Karaca, Mehmet Burak Mutlu, Kıvanç Çefle, Mustafa Nuri Yenerel, Şükrü Öztürk, Sevgi Kalayoğlu Beşışık   +8 more
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Optical genome mapping of a complex structural rearrangement family line on chromosome 18 [PDF]

Hereditas
Background Complex chromosomal rearrangement (CCR) refers to a structural rearrangement involving at least two chromosomes or a minimum of three breakpoints.
Liyi Cai, Yuying Jiang, Na Zhang, Xinying Chen   +3 more
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Optimization of serum-free medium supplemented with microalgal extract using response surface methodology for human fibroblast culture [PDF]

Journal of Biological Engineering
Background Animal cell culture has become an essential tool in biomedical research and industrial vaccine and biopharmaceutical development. Fetal bovine serum (FBS) is widely used as a culture supplement because of its rich composition of nutrients and ...
Eun-Jeong Koh, Won-Kyu Lee, Seong-Yeong Heo, Areumi Park, Eunyoung Jo, Woon-Yong Choi, Soo-Jin Heo   +6 more
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Case Report: Unraveling complex genomic alterations in a case of chronic lymphocytic leukemia using optical genome mapping [PDF]

Frontiers in Oncology
Chronic lymphocytic leukemia (CLL) is one of the most prevalent adult leukemias, derived from mature B-cells and exhibiting a highly heterogeneous disease course. Standard cytogenetic analysis of CLL includes FISH and karyotyping.
Leila Youssefian, Trilochan Sahoo, Jia-Chi Wang   +2 more
doaj   +2 more sources