Results 131 to 140 of about 131,193 (312)
To address the limitations of existing models, this study innovatively established a mouse model of endometriosis (EMs) capable of mimicking cyclic bleeding. Our results confirmed that this model recapitulates the complete pathological progression from ectopic lesion establishment to systemic responses, exhibiting superior clinical relevance compared ...
Yu Zhuang +7 more
wiley +1 more source
The Dynamics of Neurofilament Light Chain in Spinal Muscular Atrophy
Objective Newborn screening (NBS) for spinal muscular atrophy (SMA) facilitates early diagnosis and treatment for affected individuals. However, fluid biomarkers that provide early insights into disease activity and outcomes in a neonatal cohort and those unable to access (due to reimbursement criteria) or deferring immediate treatment are lacking ...
Arlene D'Silva +13 more
wiley +1 more source
A Synergistic Inhibitor Development Strategy Against Human UDP‐Galactose‐4‐Epimerase
The epimerase GalE is crucial for the biosynthesis of cancer‐relevant O‐GalNAc glycans. Here, we employ orthogonal, structurally enabled small molecule fragment screens to yield both covalent and non‐covalent inhibitors against GalE within no more than 22 elaborated compounds.
William M. Browne +22 more
wiley +1 more source
ABSTRACT In Upper Mesopotamia, the transition from the Pre‐Pottery Neolithic A (PPNA) to Pre‐Pottery Neolithic B (PPNB) period, ca. 10 800–10 600 cal. BP, is marked by a series of changes in chipped stone industries, architectural forms, symbolic objects, regional distribution of settlements and long‐distance exchange networks among others.
Toshihiro Tada +7 more
wiley +1 more source
Hidden No More: Spotlight on Tidal Disruption Events in Active Galactic Nuclei
ABSTRACT Tidal disruption events (TDEs) are typically discovered in previously quiescent galaxies. However, earlier studies have revealed a handful of TDEs occurring in pre‐existing active galactic nuclei (AGN). We discuss AT2019aalc, a promising TDE candidate in an AGN, and compare it to similar sources.
Patrik Milán Veres
wiley +1 more source
Beyond the Basics: Revision Hip Capsular Management and Advanced Closure Technique
Hip arthroscopy is an increasingly common procedure to treat intra‐articular conditions such as labral tears and femoroacetabular impingement. With the increase in frequency of such procedures, so too are revision arthroscopic hip procedures. Capsular repair in the setting of revision hip arthroscopy can be challenging due to the presence of adhesions ...
Alexander C. Hayden +5 more
wiley +1 more source
Abstract Early meniscal repair and anatomic reconstruction in a multiligament knee injury optimizes outcomes and restores tibiofemoral mechanics. This technique describes a lateral meniscus posterior root and radial tear repair, with concomitant medial ramp repair, performed during single‐stage reconstruction of the anterior cruciate ligament ...
Romir Patel +6 more
wiley +1 more source
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale +5 more
wiley +1 more source

