Characterisation of Cyanobacterial Strains Originating from the Baltic Sea with Emphasis on Nodularia and its Toxin, Nodularin [PDF]
, 2000 Lehtimäki, Jaana
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ABC Transporters in Prorocentrum lima and Their Expression Under Different Environmental Conditions Including Okadaic Acid Production. [PDF]
Mar Drugs, 2019 Gu S +5 more
europepmc +1 more source
The GSK3β inhibitor, TDZD-8, rescues cognition in a zebrafish model of okadaic acid-induced Alzheimer's disease. [PDF]
Neurochem Int, 2019 Koehler D, Shah ZA, Williams FE.
europepmc +1 more source
Prorocentrum lima (Microalgae: Dinoflagellata): killer food for zooplankton [PDF]
, 2000 Ajuzie, C.C., Houvenaghel, G.
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Binding competition of okadaic acid derivatives to anti-okadaic acid antibody
Toxicon, 1991The serologic activities of structurally related okadaic acid derivatives have been determined. Binding of [3H]okadaic acid to rabbit anti-okadaic acid is inhibited with equal effectiveness by okadaic acid, dinophysistoxin-1, acanthifolicin, okadaic acid tetramethyl ether, and okadaic acid spiroketal II.
J, Yatsunami +6 more
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Influence of amino acids on okadaic acid production
Toxicon, 2001Okadaic acid (OA) (1)) was the first example of a group of polyether toxins known to be produced by marine microalgae, which are responsible for the natural phenomena known as Diarrhetic Shellfish Poisoning (DSP) red tides. It is also a highly selective inhibitor of protein phosphatases type 1 (PP1) and 2A (PP2A), as well as being a potent tumour ...
M L, Souto +4 more
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Induction of actin cytoskeleton rearrangement by methyl okadaate – comparison with okadaic acid
The FEBS Journal, 2008Methyl okadaate is a derivative of the lipophilic polyether okadaic acid (OA), a well‐known inducer of apoptosis. OA inhibits Ser/Thr protein phosphatases (PPs), among them types 1 and 2A (PP1 and PP2A), whereas methyl okadaate lacks PP1/PP2A inhibitory activityin vitro.
Natalia, Vilariño +6 more
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Okadaic acid augments utrophin in myogenic cells
Neuroscience Letters, 2004Duchenne muscular dystrophy is a fatal childhood disease caused by mutations that abolish the expression of dystrophin in muscle. Utrophin is a paralogue of dystrophin and can functionally replace it in skeletal muscle. A potential therapeutic approach is to increase utrophin levels in muscle.
Marianna, Rodova +2 more
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Okadaic acid (OA): Toxicity, detection and detoxification
Toxicon, 2019Okadaic acid (OA), a potent polyether marine toxin, accumulates in the digestive glands of marine mollusks and therefore can severely threaten the health of humans after ingestion of contaminated shellfish. In vivo and in vitro studies have revealed that exposure of various cells, including human embryonic amniotic cells, hepatocytes, neuroblastoma ...
Ling-Ling, Fu +3 more
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