Results 181 to 190 of about 14,228 (214)
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Self-Assembly of Okadaic Acid as a Pathway to the Cell
Organic Letters, 2007The polyether toxin okadaic acid (OA) inhibits several protein serine/threonine phosphatases that play central roles in the regulation of many essential cellular processes. The use of scanning tunneling microscopy (STM) shows that dimerization of such toxins is crucial to understand the mechanism of toxin transport across model membranes.
Hernández Daranas, Antonio +4 more
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Calpain activation in okadaic-acid-induced neurodegeneration
NeuroReport, 2006Calpain activation has been implicated in the pathogenesis of Alzheimer's disease. Okadaic acid, a protein phosphatase-2A inhibitor, has been used in Alzheimer's disease research models to increase tau phosphorylation and induce neuronal death. We previously reported that okadaic acid induced predominant activation of caspase-3 in immature neurons, but
SeungYong, Yoon +4 more
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Production of antibodies and development of a radioimmunoassay for okadaic acid
Toxicon, 1988An okadaic acid immunogen, prepared by conjugation of okadaic acid to bovine albumin with carbodiimide, was used to immunize two rabbits. The rabbits responded by producing antibodies that neutralized okadaic acid's stimulation of arachidonic acid metabolism and this neutralization increased during the course of immunization.
L, Levine +5 more
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Effects of okadaic acid on mitotic HeLa cells
Journal of Cell Science, 1992ABSTRACT Mitotic HeLa cells were treated with different concentrations of okadaic acid (OA), known to inhibit phosphatase 1 and 2A activities. The cytological effects on the course of mitosis were studied at the light microscopic, immunofluorescence and electron microscopic levels. At the lowest concentration used (1 nM), OA did not show
S, Ghosh, N, Paweletz, D, Schroeter
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In vitro bioaccessibility of the marine biotoxin okadaic acid in shellfish
Food and Chemical Toxicology, 2016Okadaic acid (OA) and their derivatives are marine toxins responsible for the human diarrhetic shellfish poisoning (DSP). To date the amount of toxins ingested in food has been considered equal to the amount of toxins available for uptake by the human body.
Ana C. Braga +5 more
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Effect of okadaic acid on leukocyte movement.
Biochemistry and molecular biology international, 1993The effect of Okadaic acid (OA), a potent inhibitor of intracellular phosphatases, on neutrophil movement was studied. 1) Random movement was suppressed by OA at a concentration of 200 ng/ml. 2) Chemotaxis was suppressed by OA at concentrations between 50 and 100 ng/ml and completely suppressed at concentrations above 200 ng/ml.
M, Yokota, N, Tatsumi, I, Yano
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Unique features of the okadaic acid activity class of tumor promoters
Journal of Cancer Research and Clinical Oncology, 1999Hirota Fujiki +2 more
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