Mapping the substrate landscape of protein phosphatase 2A catalytic subunit PPP2CA [PDF]
iScienceSummary: Protein phosphatase 2A (PP2A) is an essential Ser/Thr phosphatase. The PP2A holoenzyme complex comprises a scaffolding (A), regulatory (B), and catalytic (C) subunit, with PPP2CA being the principal catalytic subunit.
Abigail Brewer +5 more
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ULK1 phosphorylation of striatin activates protein phosphatase 2A and autophagy
Cell Reports, 2021 Summary: The evolutionarily conserved ULK1 kinase complex acts as gatekeeper of canonical autophagy and regulates induction of autophagosome biogenesis.
Zehan Hu +9 more
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Protein Phosphatase 2A as a Therapeutic Target in Pulmonary Diseases [PDF]
Medicina, 2023 New disease targets and medicinal chemistry approaches are urgently needed to develop novel therapeutic strategies for treating pulmonary diseases.
Howard Yu +8 more
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Protein phosphatase 2A methylation state impacts α-synucleinopathy in mouse models [PDF]
Cell Death DiscoveryThe accumulation of aggregated alpha-Synuclein (α-Syn) in Lewy bodies and Lewy neurites is a hallmark of Parkinson’s disease (PD) and Dementia with Lewy Bodies (DLB), and phosphorylation of α-Syn at Ser129 is a key pathological marker in ...
Santhosh Maddila +6 more
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Protein Phosphatase 2A: Role in T Cells and Diseases [PDF]
Journal of Immunology Research, 2023 Protein phosphatase 2A (PP2A) is a serine–threonine phosphatase that plays an important role in the regulation of cell proliferation and signal transduction.
Suyasha Roy, Lalit Batra
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Protein phosphatase 2A regulates senescence and immunogenicity in medulloblastoma models [PDF]
The Journal of Clinical InvestigationMedulloblastoma (MB) is the most common malignant pediatric brain tumor. Current therapies are associated with substantial morbidity, and prognosis remains poor in high-risk subgroups, particularly those with TP53 mutations or relapsed disease.
Winson S. Ho +12 more
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Association of Cbl-Interacting Protein CIN85 with Protein Phosphatase 2A (PP2A) Partly Confer Neoplastic Properties to Human Leukemia Cell Lines [PDF]
CellsProtein phosphatase 2A (PP2A) is a critical tumor suppressor frequently inactivated in hematological malignancies, yet the mechanisms underlying this dysregulation remain poorly defined.
Malak Abdullah Aldahami +6 more
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Protein phosphatase 2A orchestrates hematopoietic fate determination via modulation of lactate metabolism [PDF]
HaematologicaAbnormal hematopoiesis is inherently linked to metabolic reprogramming. Protein phosphatase 2A (PP2A), a master regulator of hematopoietic homeostasis, has been implicated in multiple hematological disorders.
Can Liu +11 more
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Protein phosphatase 2A anchoring disruptor gene therapy for familial dilated cardiomyopathy [PDF]
Molecular Therapy: Methods & Clinical DevelopmentFamilial dilated cardiomyopathy is a prevalent cause of heart failure that results from the mutation of genes encoding proteins of diverse function. Despite modern therapy, dilated cardiomyopathy typically has a poor outcome and is the leading cause of ...
Xueyi Li +4 more
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Serine/Threonine Protein Phosphatase 2A Regulates the Transport of Axonal Mitochondria
Frontiers in Cellular Neuroscience, 2022 Microtubule-based transport provides mitochondria to distant regions of neurons and is essential for neuronal health. To identify compounds that increase mitochondrial motility, we screened 1,641 small-molecules in a high-throughput screening platform ...
Keunjung Heo +11 more
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