Protein Phosphatase 2A as a Therapeutic Target in Pulmonary Diseases [PDF]
Medicina, 2023 New disease targets and medicinal chemistry approaches are urgently needed to develop novel therapeutic strategies for treating pulmonary diseases.
Howard Yu +8 more
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Protein phosphatase 2A methylation state impacts α-synucleinopathy in mouse models [PDF]
Cell Death DiscoveryThe accumulation of aggregated alpha-Synuclein (α-Syn) in Lewy bodies and Lewy neurites is a hallmark of Parkinson’s disease (PD) and Dementia with Lewy Bodies (DLB), and phosphorylation of α-Syn at Ser129 is a key pathological marker in ...
Santhosh Maddila +6 more
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Protein phosphatase 2A dysfunction in Alzheimer’s disease [PDF]
Frontiers in Molecular Neuroscience, 2014 Protein Phosphatase 2A (PP2A) is a large family of enzymes that account for the majority of brain Ser/Thr phosphatase activity. While PP2A enzymes collectively modulate most cellular processes, sophisticated regulatory mechanisms are ultimately ...
Jean-Marie eSontag, Estelle eSontag
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Protein Phosphatase 2A: Role in T Cells and Diseases [PDF]
Journal of Immunology Research, 2023 Protein phosphatase 2A (PP2A) is a serine–threonine phosphatase that plays an important role in the regulation of cell proliferation and signal transduction.
Suyasha Roy, Lalit Batra
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Protein phosphatase 2A orchestrates hematopoietic fate determination via modulation of lactate metabolism [PDF]
HaematologicaAbnormal hematopoiesis is inherently linked to metabolic reprogramming. Protein phosphatase 2A (PP2A), a master regulator of hematopoietic homeostasis, has been implicated in multiple hematological disorders.
Can Liu +11 more
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Mapping the substrate landscape of protein phosphatase 2A catalytic subunit PPP2CA [PDF]
iScienceSummary: Protein phosphatase 2A (PP2A) is an essential Ser/Thr phosphatase. The PP2A holoenzyme complex comprises a scaffolding (A), regulatory (B), and catalytic (C) subunit, with PPP2CA being the principal catalytic subunit.
Abigail Brewer +5 more
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Protein phosphatase 2A anchoring disruptor gene therapy for familial dilated cardiomyopathy [PDF]
Molecular Therapy: Methods & Clinical DevelopmentFamilial dilated cardiomyopathy is a prevalent cause of heart failure that results from the mutation of genes encoding proteins of diverse function. Despite modern therapy, dilated cardiomyopathy typically has a poor outcome and is the leading cause of ...
Xueyi Li +4 more
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Bioengineered protein phosphatase 2A [PDF]
Bioengineered, 2013 Harmful algal blooms caused by phytoplankton can occur in all aquatic environments. Some of the algae present in these blooms are capable of producing extremely potent toxins. Due to climate change and eutrophication, harmful algal blooms are increasing on a global scale.
Juan A, Rubiolo +5 more
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Structure of the Protein Phosphatase 2A Holoenzyme [PDF]
Cell, 2006 Protein Phosphatase 2A (PP2A) plays an essential role in many aspects of cellular physiology. The PP2A holoenzyme consists of a heterodimeric core enzyme, which comprises a scaffolding subunit and a catalytic subunit, and a variable regulatory subunit.
Xu, Yanhui +9 more
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Serine/Threonine Protein Phosphatase 2A Regulates the Transport of Axonal Mitochondria
Frontiers in Cellular Neuroscience, 2022 Microtubule-based transport provides mitochondria to distant regions of neurons and is essential for neuronal health. To identify compounds that increase mitochondrial motility, we screened 1,641 small-molecules in a high-throughput screening platform ...
Keunjung Heo +11 more
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