Results 11 to 20 of about 324,787 (261)

Structure of the Protein Phosphatase 2A Holoenzyme [PDF]

Cell, 2006
Protein Phosphatase 2A (PP2A) plays an essential role in many aspects of cellular physiology. The PP2A holoenzyme consists of a heterodimeric core enzyme, which comprises a scaffolding subunit and a catalytic subunit, and a variable regulatory subunit.
Xu, Yanhui, Xing, Yongna, Chen, Yu, Chao, Yang, Lin, Zheng, Fan, Eugene, Yu, Jong W., Strack, Stefan, Jeffrey, Philip D., Shi, Yigong   +9 more
openaire   +2 more sources

Protein phosphatase 2A is a specific protamine-kinase-inactivating phosphatase [PDF]

Biochemical Journal, 1992
Purified preparations of a protamine protein kinase from bovine kidney cytosol [Damuni, Amick & Sneed (1989) J. Biol. Chem. 264, 6412-6416] were inactivated after incubation with near-homogeneous preparations of protein phosphatase 2A1 and protein phosphatase 2A2.
G D, Amick, S A, Reddy, Z, Damuni
openaire   +2 more sources

Cancerous inhibitor of protein phosphatase 2A determines bortezomib-induced apoptosis in leukemia cells

Haematologica, 2013
The multiple cellular targets affected by proteasome inhibition implicate a potential role for bortezomib, a first-in-class proteasome inhibitor, in enhancing antitumor activities in hematologic malignancies.
Chun-Yu Liu, Chung-Wai Shiau, Hsin-Yu Kuo, Hsiang-Po Huang, Ming-Huang Chen, Cheng-Hwai Tzeng, Kuen-Feng Chen   +6 more
doaj   +1 more source

Protein Phosphatase Methyl-Esterase PME-1 Protects Protein Phosphatase 2A from Ubiquitin/Proteasome Degradation.

PLoS ONE, 2015
Protein phosphatase 2A (PP2A) is a conserved essential enzyme that is implicated as a tumor suppressor based on its central role in phosphorylation-dependent signaling pathways.
Ryotaro Yabe, Akane Miura, Tatsuya Usui, Ingrid Mudrak, Egon Ogris, Takashi Ohama, Koichi Sato   +6 more
doaj   +1 more source

The structural requirements for ceramide activation of serine-threonine protein phosphatases

Journal of Lipid Research, 2004
The protein phosphatases1 (PP1) and 2A (PP2A) serve as ceramide-activated protein phosphatases (CAPP). In this study, the structural requirements for interaction between ceramide and CAPP were determined.
Charles E. Chalfant, Zdzislaw Szulc, Patrick Roddy, Alicja Bielawska, Yusuf A. Hannun   +4 more
doaj   +1 more source

MicroRNA exporter HuR clears the internalized pathogens by promoting pro‐inflammatory response in infected macrophages

EMBO Molecular Medicine, 2020
HuR is a miRNA derepressor protein that can act as miRNA sponge for specific miRNAs to negate their action on target mRNAs. Here we have identified how HuR, by inducing extracellular vesicles‐mediated export of miRNAs, ensures robust derepression of ...
Avijit Goswami, Kamalika Mukherjee, Anup Mazumder, Satarupa Ganguly, Ishita Mukherjee, Saikat Chakrabarti, Syamal Roy, Shyam Sundar, Krishnananda Chattopadhyay, Suvendra N Bhattacharyya   +9 more
doaj   +1 more source

Determinants for Substrate Specificity of Protein Phosphatase 2A [PDF]

Enzyme Research, 2011
Protein phosphatase 2A- (PP2A-) catalyzed dephosphorylation of target substrate proteins is widespread and critical for cellular function. PP2A is predominantly found as a heterotrimeric complex of a catalytic subunit (C), a scaffolding subunit (A), and one member of 4 families of regulatory subunits (B). Substrate specificity of the holoenzyme complex
Slupe, Andrew M., Merrill, Ronald A., Strack, Stefan   +2 more
openaire   +2 more sources

Memantine Attenuates Alzheimer's Disease-Like Pathology and Cognitive Impairment.

PLoS ONE, 2015
Deficiency of protein phosphatase-2A is a key event in Alzheimer's disease. An endogenous inhibitor of protein phosphatase-2A, inhibitor-1, I1PP2A, which inhibits the phosphatase activity by interacting with its catalytic subunit protein phosphatase-2Ac,
Xiaochuan Wang, Julie Blanchard, Inge Grundke-Iqbal, Khalid Iqbal   +3 more
doaj   +1 more source

Purification and characterization of a protein inhibitor from rat liver that inhibits type 1 protein phosphatase when 3-hydroxy-3-methylglutaryl CoA reductase is the substrate.

Journal of Lipid Research, 1990
A protein inhibitor of HMG-CoA reductase phosphatase activity from rat liver was purified to homogeneity. The protein was purified 4,000-fold with an overall yield of 4%. The purified protein had a molecular mass of 31 kDa.
D Serra, G Asins, FG Hegardt
doaj   +1 more source

Developmental Expression of Protein Phosphatase 2A in the Kidney [PDF]

Journal of the American Society of Nephrology, 1999
Abstract. Although a number of growth and transcription factors are known to regulate renal growth and development, the signal transduction molecules necessary to mediate these developmental signals are relatively unknown.
A D, Everett, C, Xue, T, Stoops
openaire   +2 more sources