Results 11 to 20 of about 327,828 (303)
ULK1 phosphorylation of striatin activates protein phosphatase 2A and autophagy
Cell Reports, 2021 Summary: The evolutionarily conserved ULK1 kinase complex acts as gatekeeper of canonical autophagy and regulates induction of autophagosome biogenesis.
Zehan Hu +9 more
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Interaction of nucleoredoxin with protein phosphatase 2A
FEBS Letters, 2006 A trimeric protein phosphatase 2A (PP2AT55) composed of the catalytic (PP2Ac), structural (PR65/A), and regulatory (PR55/B) subunits was isolated from rabbit skeletal muscle by thiophosphorylase affinity chromatography, and contained two additional proteins of 54 and 55 kDa, respectively.
Lechward, Katarzyna +5 more
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Protein phosphatases 1, 2A, and 2C are protein histidine phosphatases.
Journal of Biological Chemistry, 1993 Eukaryotic cellular proteins contain phosphohistidine. To search for protein histidine phosphatases, protein histidine kinase from Saccharomyces cerevisiae was used to phosphorylate histone H4 on histidine at position 75 in the H4 amino acid sequence. Incubation of the phosphorylated histone H4 with either protein phosphatase 1, 2A, or 2C resulted in ...
Kim, Y. +3 more
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The structure of protein phosphatase 2A is as highly conserved as that of protein phosphatase I [PDF]
FEBS Letters, 1990 cDNA coding for protein phosphatase 2A (PP2A) has been isolated from Drosophila head and eye imaginal disc libraries. Drosophila PP2A mRNA is expressed throughout development, but is most abundant in the early embryo. The cDNA hybridises to a single site on the left area of the second chromosomes at position 28D2‐4. The deduced amino acid sequence (309
Orgad, Sara +5 more
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Protein phosphatase 2A is a specific protamine-kinase-inactivating phosphatase [PDF]
Biochemical Journal, 1992 Purified preparations of a protamine protein kinase from bovine kidney cytosol [Damuni, Amick & Sneed (1989) J. Biol. Chem. 264, 6412-6416] were inactivated after incubation with near-homogeneous preparations of protein phosphatase 2A1 and protein phosphatase 2A2.
G D, Amick, S A, Reddy, Z, Damuni
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Haematologica, 2013 The multiple cellular targets affected by proteasome inhibition implicate a potential role for bortezomib, a first-in-class proteasome inhibitor, in enhancing antitumor activities in hematologic malignancies.
Chun-Yu Liu +6 more
doaj +1 more source
Analysis of the structure and function of protein phosphatase 2A [PDF]
, 2004 One of the hallmarks of a living organism is the ability to respond to intra- or extracellular changes. These responses involve panoply of enzymes mediating signals through the cell and regulating distinct cellular functions.
Schmidt, Karsten
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PLoS ONE, 2015 Protein phosphatase 2A (PP2A) is a conserved essential enzyme that is implicated as a tumor suppressor based on its central role in phosphorylation-dependent signaling pathways.
Ryotaro Yabe +6 more
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Monotherapy efficacy of blood-brain barrier permeable small molecule reactivators of protein phosphatase 2A in glioblastoma [PDF]
, 2020 Glioblastoma is a fatal disease in which most targeted therapies have clinically failed. However, pharmacological reactivation of tumour suppressors has not been thoroughly studied as yet as a glioblastoma therapeutic strategy.
Laakkonen, Pirjo, +26 more
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The structural requirements for ceramide activation of serine-threonine protein phosphatases
Journal of Lipid Research, 2004 The protein phosphatases1 (PP1) and 2A (PP2A) serve as ceramide-activated protein phosphatases (CAPP). In this study, the structural requirements for interaction between ceramide and CAPP were determined.
Charles E. Chalfant +4 more
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