Results 11 to 20 of about 4,194,516 (299)
Protein phosphatase 2A dysfunction in Alzheimer’s disease [PDF]
Frontiers in Molecular Neuroscience, 2014 Protein Phosphatase 2A (PP2A) is a large family of enzymes that account for the majority of brain Ser/Thr phosphatase activity. While PP2A enzymes collectively modulate most cellular processes, sophisticated regulatory mechanisms are ultimately ...
Jean-Marie eSontag, Estelle eSontag
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Role of protein phosphatase 2A inDrosophiladevelopment
Seminars in Cancer Biology, 1995 The molecular cloning of protein phosphatase 2A subunits from Drosophila has provided insights into the role this enzyme plays in developmental processes and in cell cycle regulation. The trimeric holoenzyme containing the catalytic, 65-kDa and 55-kDa regulatory subunits appears to be preferentially expressed in proliferative organs such as the gonads,
Mayer-Jaekel RE, Hemmings BA
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Protein phosphatases 1, 2A, and 2C are protein histidine phosphatases.
Journal of Biological Chemistry, 1993 Eukaryotic cellular proteins contain phosphohistidine. To search for protein histidine phosphatases, protein histidine kinase from Saccharomyces cerevisiae was used to phosphorylate histone H4 on histidine at position 75 in the H4 amino acid sequence. Incubation of the phosphorylated histone H4 with either protein phosphatase 1, 2A, or 2C resulted in ...
Kim, Y. +3 more
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Structure of the Protein Phosphatase 2A Holoenzyme [PDF]
Cell, 2006 Protein Phosphatase 2A (PP2A) plays an essential role in many aspects of cellular physiology. The PP2A holoenzyme consists of a heterodimeric core enzyme, which comprises a scaffolding subunit and a catalytic subunit, and a variable regulatory subunit.
Xu, Yanhui +9 more
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Bioengineered protein phosphatase 2A [PDF]
Bioengineered, 2013 Harmful algal blooms caused by phytoplankton can occur in all aquatic environments. Some of the algae present in these blooms are capable of producing extremely potent toxins. Due to climate change and eutrophication, harmful algal blooms are increasing on a global scale.
Juan A, Rubiolo +5 more
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Haematologica, 2013 The multiple cellular targets affected by proteasome inhibition implicate a potential role for bortezomib, a first-in-class proteasome inhibitor, in enhancing antitumor activities in hematologic malignancies.
Chun-Yu Liu +6 more
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Analysis of the structure and function of protein phosphatase 2A [PDF]
, 2004 One of the hallmarks of a living organism is the ability to respond to intra- or extracellular changes. These responses involve panoply of enzymes mediating signals through the cell and regulating distinct cellular functions.
Schmidt, Karsten
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PLoS ONE, 2015 Protein phosphatase 2A (PP2A) is a conserved essential enzyme that is implicated as a tumor suppressor based on its central role in phosphorylation-dependent signaling pathways.
Ryotaro Yabe +6 more
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Protein phosphatase 2A is a specific protamine-kinase-inactivating phosphatase [PDF]
Biochemical Journal, 1992 Purified preparations of a protamine protein kinase from bovine kidney cytosol [Damuni, Amick & Sneed (1989) J. Biol. Chem. 264, 6412-6416] were inactivated after incubation with near-homogeneous preparations of protein phosphatase 2A1 and protein phosphatase 2A2.
G D, Amick, S A, Reddy, Z, Damuni
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PPP2R4 (protein phosphatase 2A activator, regulatory subunit 4) [PDF]
, 2010 Review on PPP2R4 (protein phosphatase 2A activator, regulatory subunit 4), with data on DNA, on the protein encoded, and where the gene is ...
V Janssens +2 more
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