Results 21 to 30 of about 4,194,516 (299)
The structural requirements for ceramide activation of serine-threonine protein phosphatases
Journal of Lipid Research, 2004 The protein phosphatases1 (PP1) and 2A (PP2A) serve as ceramide-activated protein phosphatases (CAPP). In this study, the structural requirements for interaction between ceramide and CAPP were determined.
Charles E. Chalfant +4 more
doaj +1 more source
EMBO Molecular Medicine, 2020 HuR is a miRNA derepressor protein that can act as miRNA sponge for specific miRNAs to negate their action on target mRNAs. Here we have identified how HuR, by inducing extracellular vesicles‐mediated export of miRNAs, ensures robust derepression of ...
Avijit Goswami +9 more
doaj +1 more source
The TriTryp phosphatome:analysis of the protein phosphatase catalytic domains [PDF]
, 2007 Background The genomes of the three parasitic protozoa Trypanosoma cruzi, Trypanosoma brucei and Leishmania major are the main subject of this study. These parasites are responsible for devastating human diseases known as Chagas disease, African sleeping
Szoor, Balazs; id_orcid +18 more
core +1 more source
Memantine Attenuates Alzheimer's Disease-Like Pathology and Cognitive Impairment.
PLoS ONE, 2015 Deficiency of protein phosphatase-2A is a key event in Alzheimer's disease. An endogenous inhibitor of protein phosphatase-2A, inhibitor-1, I1PP2A, which inhibits the phosphatase activity by interacting with its catalytic subunit protein phosphatase-2Ac,
Xiaochuan Wang +3 more
doaj +1 more source
Determinants for Substrate Specificity of Protein Phosphatase 2A [PDF]
Enzyme Research, 2011 Protein phosphatase 2A- (PP2A-) catalyzed dephosphorylation of target substrate proteins is widespread and critical for cellular function. PP2A is predominantly found as a heterotrimeric complex of a catalytic subunit (C), a scaffolding subunit (A), and one member of 4 families of regulatory subunits (B). Substrate specificity of the holoenzyme complex
Slupe, Andrew M. +2 more
openaire +2 more sources
Journal of Lipid Research, 1990 A protein inhibitor of HMG-CoA reductase phosphatase activity from rat liver was purified to homogeneity. The protein was purified 4,000-fold with an overall yield of 4%. The purified protein had a molecular mass of 31 kDa.
D Serra, G Asins, FG Hegardt
doaj +1 more source
Sex-specific regulation of the cardiac transcriptome by the protein phosphatase 2A regulatory subunit B55α. [PDF]
NPJ Metab Health DisSex-specific regulation of the cardiac transcriptome by the protein phosphatase 2A regulatory subunit ...
Sergienko NM +11 more
europepmc +2 more sources
Protein phosphatase 2A: a target for anticancer therapy [PDF]
The Lancet Oncology, 2013 Protein phosphatase 2A (PP2A), one of the main serine-threonine phosphatases in mammalian cells, maintains cell homoeostasis by counteracting most of the kinase-driven intracellular signalling pathways. Unrestrained activation of oncogenic kinases together with inhibition of tumour suppressors is often required for development of cancer.
Danilo, Perrotti, Paolo, Neviani
openaire +2 more sources
Enhanced insulin sensitivity associated with provision of mono and polyunsaturated fatty acids in skeletal muscle cells involves counter modulation of PP2A [PDF]
, 2014 Aims/HypothesisReduced skeletal muscle insulin sensitivity is a feature associated with sustained exposure to excess saturated fatty acids (SFA), whereas mono and polyunsaturated fatty acids (MUFA and PUFA) not only improve insulin sensitivity but blunt ...
Hage Hassan, Rima +22 more
core +2 more sources
, 2022 Supplementary Figure from Protein Phosphatase 2A–Dependent Mitotic hnRNPA1 Dephosphorylation and TERRA Formation Facilitate Telomere ...
Jiang-Dong Sui (15099089) +11 more
core +1 more source