Results 1 to 10 of about 35,429 (234)

Therapeutic targeting of PP2A [PDF]

International Journal of Biochemistry and Cell Biology, 2018
Protein phosphatase 2A (PP2A) is a major serine/threonine phosphatase that regulates many cellular processes. Given the central role of PP2A in regulating diverse biological functions and its dysregulation in many diseases, including cancer, PP2A directed therapeutics have become of great interest.
Daniel Leonard, Abbey L Perl, Caitlin M O'Connor   +2 more
exaly   +3 more sources

PP2A: The Wolf in Sheep’s Clothing? [PDF]

Cancers, 2015
Protein Phosphatase 2A (PP2A) is a major serine/threonine phosphatase in cells. It consists of a catalytic subunit (C), a structural subunit (A), and a regulatory/variable B-type subunit. PP2A has a critical role to play in homeostasis where its predominant function is as a phosphatase that regulates the major cell signaling pathways in cells ...
Maeve Bailey-Whyte, Patrick Kiely
exaly   +3 more sources

The PP2A subunit PR130 is a key regulator of cell development and oncogenic transformation

Biochimica Et Biophysica Acta: Reviews on Cancer, 2020
Andreas Henke, Günter Schneider, Oliver H Kramer   +2 more
exaly  

All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase

FEBS Journal, 2016
Matthew D Galsky, Caroline C Farrington, Goutham Narla   +2 more
exaly  

PP2A regulates autophagy in two alternative ways in Drosophila

Autophagy, 2012
Tamás Lukácsovich, György Csikós, Miklós Erdélyi   +2 more
exaly  

Phosphatases in apoptosis: to be or not to be, PP2A is in the heart of the question

Biochimica Et Biophysica Acta - Molecular Cell Research, 2003
Józef Goris, Christine van Hoof
exaly  

Phosphatase PP2A is essential for TH17 differentiation

Proceedings of the National Academy of Sciences of the United States of America, 2019
Lie Wang, Deepak Rohila, Linrong Lu
exaly  

Functional importance of PP2A regulatory subunit loss in breast cancer

Breast Cancer Research and Treatment, 2017
Abdul Mannan, Séverine Roselli, Nicole M Verrills   +2 more
exaly  

Physiologic functions of PP2A: Lessons from genetically modified mice

Biochimica Et Biophysica Acta - Molecular Cell Research, 2019
Veerle Janssens, Sara Reynhout
exaly  

Crystal structure of a PP2A B56-BubR1 complex and its implications for PP2A substrate recruitment and localization [PDF]

Protein and Cell, 2016
Protein phosphatase 2A (PP2A) accounts for the majority of total Ser/Thr phosphatase activities in most cell types and regulates many biological processes.
David M. Virshup, Rao Zihe, Geert Kops
exaly   +5 more sources