Results 41 to 50 of about 35,429 (234)
PP2A-B' holoenzyme substrate recognition, regulation and role in cytokinesis.
, 2017 Protein phosphatase 2A (PP2A) is a major Ser/Thr phosphatase; it forms diverse heterotrimeric holoenzymes that counteract kinase actions. Using a peptidome that tiles the disordered regions of the human proteome, we identified proteins containing [LMFI ...
Yadav, V.
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Genetic Variant of PP2A Subunit Gene Confers an Increased Risk of Primary Liver Cancer in Chinese
Pharmacogenomics and Personalized Medicine, 2021 Youxin Wang,1,* Qiuyue Huang,1,* Xinglei Huang,1 Huiliu Zhao,2 Bin Guan,1 Kechen Ban,3 Xuefeng Zhu,1 Zhixing Ma,1 Yanmei Tang,1 Zhaohui Su,1 Qingqing Nong1 1Department of Environmental Health, School of Public Health, Guangxi Medical University ...
Wang Y +10 more
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Journal of Pharmacological Sciences, 2022 Studies have shown that inhibition of PI3K/AKT signaling is a key strategy for the treatment of tyrosine kinase inhibitor resistance in non-small cell lung cancer (NSCLC).
Yu Zhang +6 more
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PP2A Activators Stabilize PP2A Complexes with Differing Specificities [PDF]
Cancer Discovery, 2020 Abstract Anticancer PP2A activators facilitated assembly of holoenzymes with unique regulatory subunits.
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Journal of Experimental & Clinical Cancer Research, 2018 Background JS-K is a nitric oxide (NO) donor and could generate intracellularly high levels of NO. The study explores PP2A as a tumor suppressor is a major determinant mediating JS-K-caused apoptosis in human hepatocellular carcinoma (HCC) cells. Methods
Ling Liu +4 more
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Investigation of PP2A and Its Endogenous Inhibitors in Neuroblastoma Cell Survival and Tumor Growth
Translational Oncology, 2019 High-risk neuroblastoma continues to carry a poor prognosis. Nearly 50% of these tumors relapse following extensive treatment regimens. Protein phosphatase 2A (PP2A), a tumor suppressor, has been shown to be downregulated in many human cancers via ...
Adele P. Williams +7 more
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PP2A Regulates HDAC4 Nuclear Import [PDF]
Molecular Biology of the Cell, 2008 Different signal-regulated serine/threonine kinases phosphorylate class II histone deacetylases (HDACs) to promote nuclear export, cytosolic accumulation, and activation of gene transcription. However, little is known about mechanisms operating in the opposite direction, which, possibly through phosphatases, should promote class II HDACs nuclear entry ...
BRANCOLINI, Claudio +9 more
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The Molecular Mechanism of Alpha-Synuclein Dependent Regulation of Protein Phosphatase 2A Activity
Cellular Physiology and Biochemistry, 2018 Background/Aims: Alpha-synuclein (α-Syn) is a neuronal protein that is highly implicated in Parkinson’s disease (PD), and protein phosphatase 2A (PP2A) is an important serine/threonine phosphatase that is associated with neurodegenerative diseases, such ...
Jing Qu +8 more
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Cell Cycle, 2016 Meiosis is a specialized type of cell division in which one round of DNA replication is followed by 2 consecutive rounds of chromosome segregation.
Xiumin Yan, Xueliang Zhu
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Phospho-Akt expression is high in a subset of triple negative breast cancer patients [PDF]
, 2014 The most commonly used biomarkers to predict the response of breast cancer patients to therapy are oestrogen receptor (ER), progesterone receptor (PgR), and human epidermal growth factor receptor 2 (HER2).
Baldacchino, Shawn +6 more
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