Results 31 to 40 of about 35,429 (234)
Enhanced insulin sensitivity associated with provision of mono and polyunsaturated fatty acids in skeletal muscle cells involves counter modulation of PP2A [PDF]
, 2014 Aims/HypothesisReduced skeletal muscle insulin sensitivity is a feature associated with sustained exposure to excess saturated fatty acids (SFA), whereas mono and polyunsaturated fatty acids (MUFA and PUFA) not only improve insulin sensitivity but blunt ...
Hage Hassan, Rima +22 more
core +2 more sources
Inhibitor-1 and -2 of PP2A have preference between PP2A complexes [PDF]
Biochemical and Biophysical Research Communications, 2015 Protein phosphatase 2A (PP2A) forms tens of kinds of complexes with different substrate specificity and functions by using various regulatory B subunits. But how these complexes' activities are regulated separately is not well understood. Here we showed unequal enzyme inhibition of each form by two proteinous PP2A inhibitors, I1(PP2A) and I2(PP2A ...
Hirotsugu, Hino +2 more
openaire +2 more sources
Protein phosphatase 2A mediates dormancy of glioblastoma multiforme-derived tumor stem-like cells during hypoxia. [PDF]
PLoS ONE, 2012 The hypoxic microenvironment of glioblastoma multiforme (GBM) is thought to increase resistance to cancer therapies. Recent evidence suggests that hypoxia induces protein phosphatase 2A (PP2A), a regulator of cell cycle and cell death.
Christoph P Hofstetter +8 more
doaj +1 more source
An axonemal PP2A B‐subunit is required for PP2A localization and flagellar motility [PDF]
Cytoskeleton, 2011 AbstractAnalysis of Chlamydomonas axonemes revealed that the protein phosphatase, PP2A, is localized to the outer doublet microtubules and is implicated in regulation of dynein‐driven motility. We tested the hypothesis that PP2A is localized to the axoneme by a specialized, highly conserved 55‐kDa B‐type subunit identified in the Chlamydomonas ...
Candice A, Elam +7 more
openaire +2 more sources
Analysis of the structure and function of protein phosphatase 2A [PDF]
, 2004 One of the hallmarks of a living organism is the ability to respond to intra- or extracellular changes. These responses involve panoply of enzymes mediating signals through the cell and regulating distinct cellular functions.
Schmidt, Karsten
core +1 more source
PP2A inactivation by ROS accumulation [PDF]
Blood, 2014 In this issue of Blood, Low and colleagues show that reactive oxygen species (ROS)–mediated phosphorylation of Bcl-2 overcomes chemoresistance in hematopoietic malignancies and other cancers and that this function is mediated by selective nitration of Y289 on the Bcl-2–bound B56δ subunit of protein phosphatase 2A (PP2A), which interferes with the ...
Shingo, Nakahata, Kazuhiro, Morishita
openaire +2 more sources
Cells, 2019 Adenylyl cyclase type 5 (AC5), as the principal isoform expressed in striatal medium spiny neurons (MSNs), is essential for the integration of both stimulatory and inhibitory midbrain signals that initiate from dopaminergic G protein-coupled receptor ...
Trevor B. Doyle +8 more
doaj +1 more source
Frontiers in Cardiovascular Medicine, 2022 Protein phosphatase 2A (PP2A), a crucial serine/threonine phosphatase, has recently been reported to play an important role in cardiovascular disease.
Rui Li +8 more
doaj +1 more source
Structural basis for PP2A-mediated regulation of accurate chromosome segregation
, 2023 The dynamic crosstalk between kinases and phosphatases is essential to ensure faithful mitosis. Protein phosphatases PP2A(B55) and PP2A(B56), and the Chromosomal Passenger Complex -CPC, containing Aurora B kinase-, establish a signalling network that ...
Sotelo Parrilla, Paula
core +1 more source
Protein Phosphatase 2A: Role in T Cells and Diseases
Journal of Immunology Research, 2023 Protein phosphatase 2A (PP2A) is a serine–threonine phosphatase that plays an important role in the regulation of cell proliferation and signal transduction.
Suyasha Roy, Lalit Batra
doaj +1 more source