Results 11 to 20 of about 35,429 (234)
PP2A-Mediated Anticancer Therapy [PDF]
Gastroenterology Research and Practice, 2013 PP2A is a family of mammalian serine/threonine phosphatases that is involved in the control of many cellular functions including protein synthesis, cellular signaling, cell cycle determination, apoptosis, metabolism, and stress responses through the ...
Weibo Chen +3 more
doaj +5 more sources
The Interaction Mechanism of Intrinsically Disordered PP2A Inhibitor Proteins ARPP-16 and ARPP-19 With PP2A [PDF]
Frontiers in Molecular Biosciences, 2021 Protein phosphatase 2A (PP2A) activity is critical for maintaining normal physiological cellular functions. PP2A is inhibited by endogenous inhibitor proteins in several pathological conditions including cancer.
Chandan Thapa +11 more
doaj +9 more sources
Interaction mechanism of endogenous PP2A inhibitor protein ENSA with PP2A [PDF]
The FEBS Journal, 2021 The vast diversity of protein phosphatase 2A (PP2A) holoenzyme composition ensures its multifaceted role in the regulation of cellular growth and signal transduction. In several pathological conditions, such as cancer, PP2A is inhibited by endogenous inhibitor proteins. Several PP2A inhibitor proteins have been identified, one of which is α‐endosulfine
Roivas, Pekka +5 more
core +9 more sources
Specific interactions of PP2A and PP2A-like phosphatases with the yeast PTPA homologues, Ypa1 and Ypa2 [PDF]
Biochemical Journal, 2005 To elucidate the specific biological role of the yeast homologues of PTPA (phosphatase 2A phosphatase activator), Ypa1 and Ypa2 (where Ypa stands for yeast phosphatase activator), in the regulation of PP2A (protein phosphatase 2A), we investigated the physical interaction of both Ypa proteins with the catalytic subunit of the different yeast PP2A-like ...
Christine, Van Hoof +6 more
core +6 more sources
RAS and PP2A activities converge on epigenetic gene regulation [PDF]
Life Science Alliance, 2023 This study reveals a hidden regulatory layer in epigenetic gene expression in cancer by co-operative phosphoregulation by RAS and tumor suppressor phosphatase PP2A.
Anna Aakula +9 more
doaj +3 more sources
Review of PP2A Tumor Biology and Antitumor Effects of PP2A Inhibitor LB100 in the Nervous System [PDF]
Cancers, 2021 Protein phosphatase 2A (PP2A) is a ubiquitous serine/threonine phosphatase implicated in a wide variety of regulatory cellular functions. PP2A is abundant in the mammalian nervous system, and dysregulation of its cellular functions is associated with myriad neurodegenerative disorders.
Jean-Paul Bryant +3 more
openaire +3 more sources
The Interplay between PP2A and MicroRNAs in Leukemia [PDF]
Frontiers in Oncology, 2015 Protein Phosphatase 2A (PP2A) is a serine/threonine phosphatase family whose members have been implicated in tumor suppression in many cancer models. In many cancers, loss of PP2A activity has been associated with tumorigenesis and drug resistance.
Peter eRuvolo
doaj +3 more sources
Regulation of PP2A by Sphingolipid Metabolism and Signaling [PDF]
Frontiers in Oncology, 2015 Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase that is a primary regulator of cellular proliferation through targeting of proliferative kinases, cell cycle regulators, and apoptosis inhibitors.
Joshua eOaks, Besim eOgretmen
doaj +2 more sources
Metformin induces senescence of colorectal cancer cells through PP2A/AKT pathway
Di-san junyi daxue xuebao, 2021 Objective To determine whether metformin(Met) inhibits the proliferation of colorectal cancer cells by inducing cell senescence, and to preliminarily explore the underlying mechanism.
YANG Jianying +7 more
doaj +1 more source
PP2A and tumor radiotherapy [PDF]
Hereditas, 2020 AbstractProtein phosphatase 2A (PP2A) is a serine/threonine phosphatase that serves as a key regulator of cellular physiology in the context of apoptosis, mitosis, and DNA damage responses. Canonically, PP2A functions as a tumor suppressor gene. However, recent evidence suggests that inhibiting PP2A activity in tumor cells may represent a viable ...
Xiao Lei +6 more
openaire +3 more sources