Results 21 to 30 of about 35,429 (234)

Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition [PDF]

, 2022
Protein phosphatase 2A (PP2A) holoenzymes target broad substrates by recognizing short motifs via regulatory subunits. PP2A methylesterase 1 (PME-1) is a cancer-promoting enzyme and undergoes methylesterase activation upon binding to the PP2A core enzyme.
Li, Yitong, Anastasia Phoebe Bravos, Vikash K Yadav, Novikova, Irina V, Novikova, I. V., Vijaya Kumar Balakrishnan, Ivarsson, Ylva,, Li, Y., Balakrishnan, Vijaya Kumar . K., Rowse, Michael,, Irina V Novikova, Wu, C, G., Yadav, Vikash K, Cheng-Guo Wu, Novikova, Irina, V, Ivarsson, Ylva, Xing, Yongna,, Rowse, Michael, Strack, Stefan,, Ylva Ivarsson, Balakrishnan, Vijaya Kumar,, Strack, Stefan, Stefan Strack, Balakrishnan, Vijaya Kumar, Ivarsson, Y., Bravos, Anastasia Phoebe, Li, Yitong,, Novikova, Irina, V,, Yongna Xing, Rowse, M., Michael Rowse, Wu, Cheng-Guo, Wu, Cheng-Guo,, Yadav, Vikash K.,, Xing, Y., Yitong Li, Bravos, A. P., Strack, S., Bravos, Anastasia Phoebe,, Yadav, Vikash K., Xing, Yongna, Yadav, VK   +41 more
core   +1 more source

Corynoxine Inhibits Tumor Growth via Targeting NQO1 and Modulating the PTPA-NQO1/PP2A Switch to Activate PP2A. [PDF]

Adv Sci (Weinh)
Corynoxine exerts potent broad‐spectrum anticancer activity by directly targeting NQO1. This interaction dissociates the oncogenic NQO1‐PTPA complex, releasing PTPA to robustly activate the tumor suppressor PP2A. Consequently, downstream Raf/MEK/ERK and PI3K/AKT signaling pathways are suppressed, downregulating c‐Myc and driving tumor regression ...
Hou G, Lin L, Xia M, Liang R, Zhang Y, Du L, Cao X.   +6 more
europepmc   +2 more sources

The overlooked greatwall: a new perspective on mitotic control [PDF]

Open Biology, 2012
The role of the dual specificity protein phosphatase, Cdc25, in activating the cyclin-dependent kinase-cyclin B complex (Cdk1-CycB) by overcoming the inhibitory Wee1 kinase is a long-established principle for mitotic entry.
David M. Glover
doaj   +1 more source

Adventures of the undead at kinetochores

Molecular & Cellular Oncology, 2021
At the metaphase-to-anaphase transition, phosphatase activity feeds back to reverse early mitotic phosphorylation events. Our recent work indicates that the pseudokinase domain of the spindle checkpoint protein BUB1 (Budding Uninhibited by Benzimidazoles
Sabine Elowe
doaj   +1 more source

PP2A Regulatory Subunit PP2A-B′ Counteracts S6K Phosphorylation [PDF]

Cell Metabolism, 2010
The insulin/TOR signaling pathway plays a crucial role in animal homeostasis, sensing nutrient status to regulate organismal growth and metabolism. We identify here the Drosophila B' regulatory subunit of PP2A (PP2A-B') as a novel, conserved component of the insulin pathway that specifically targets the PP2A holoenzyme to dephosphorylate S6K.
Hahn, Katrin, Miranda, Merce, Francis, Víctor A., Vendrell, Joan, Zorzano, Antonio, Teleman, Aurelio A.   +5 more
openaire   +2 more sources

A PP2A-B56—Centered View on Metaphase-to-Anaphase Transition in Mouse Oocyte Meiosis I

Cells, 2020
Meiosis is required to reduce to haploid the diploid genome content of a cell, generating gametes—oocytes and sperm—with the correct number of chromosomes.
Leonor Keating, Sandra A. Touati, Katja Wassmann   +2 more
doaj   +1 more source

Protein Phosphatase 2A as a Therapeutic Target in Pulmonary Diseases

Medicina, 2023
New disease targets and medicinal chemistry approaches are urgently needed to develop novel therapeutic strategies for treating pulmonary diseases.
Howard Yu, Sahil Zaveri, Zeeshan Sattar, Michael Schaible, Brais Perez Gandara, Anwar Uddin, Lucas R. McGarvey, Michael Ohlmeyer, Patrick Geraghty   +8 more
doaj   +1 more source

PP2A

, 2021
Tape PP2A Genderang & Gendang Mengeragam 1.Tat. Sukut Singkole (starts ~1:15) 2.Tat. Puang Sisangkar (starts ~6:05) 3.Tat. Senina Jumagulangan (starts ~11:05) 4.Tat. Berru Semep-Semep Keliki (starts ~16:10) 5.Tat.
Traditional Musicians (11720099), Lynette Moore (11720102)   +1 more
core   +1 more source

The Role of MYC and PP2A in the Initiation and Progression of Myeloid Leukemias

Cells, 2020
The MYC transcription factor is one of the best characterized PP2A substrates. Deregulation of the MYC oncogene, along with inactivation of PP2A, are two frequent events in cancer.
Raffaella Pippa, Maria D. Odero
doaj   +1 more source

PP2A Facilitates Porcine Reproductive and Respiratory Syndrome Virus Replication by Deactivating irf3 and Limiting Type I Interferon Production

Viruses, 2019
Protein phosphatase 2A (PP2A), a major serine/threonine phosphatase in mammalian cells, is known to regulate the kinase-driven intracellular signaling pathways.
Jiayu Xu, Lu Zhang, Yunfei Xu, He Zhang, Junxin Gao, Qian Wang, Zhijun Tian, Lv Xuan, Hongyan Chen, Yue Wang   +9 more
doaj   +1 more source