Results 61 to 70 of about 35,429 (234)

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source

CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer’s Disease

Cell Reports, 2018
Summary: Protein phosphatase 2A (PP2A) inhibition causes hyperphosphorylation of tau and APP in Alzheimer’s disease (AD). However, the mechanisms underlying the downregulation of PP2A activity in AD brain remain unclear.
Yang-Ping Shentu, Yuda Huo, Xiao-Long Feng, James Gilbert, Qing Zhang, Zhen-Yu Liuyang, Xiu-Lian Wang, Guan Wang, Huan Zhou, Xiao-Chuan Wang, Jian-Zhi Wang, You-Ming Lu, Jukka Westermarck, Heng-Ye Man, Rong Liu   +14 more
doaj   +1 more source

Regulation and role of the PP2A-B56 holoenzyme family in cancer

, 2023
Protein phosphatase 2A (PP2A) inactivation is common in cancer, leading to sustained activation of pro-survival and growth-promoting pathways. PP2A consists of a scaffolding A-subunit, a catalytic C-subunit, and a regulatory B-subunit.
Peris-Martínez, I. (Irene), Odero-de Dios, M. (María Dolores), Romero-Murillo, S. (Silvia), Vicente-Vázquez, C. (Carmen), Narla, G.   +4 more
core  

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

Advanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie, Ziye Huang, Zhiyuan Zhang, Yiqiang Zhu, Xiaoqing Liu, Lei Wang, Tongyu Bi, Taizhen Liang, Jintao Lai, Meilin Hu, Guochang Qiu, Shiqi Xiao, Sen Liu, Yaoming Liu, Haiyue Rao, Tao Chen, Haojie Peng, Bin Zhang, Jia Tang, Qianying Li, Yaxin Li, Yuxin Hou, Weibo Yang, Hewei Jiang, Xiancai Ma   +24 more
wiley   +1 more source

Role for PP2A in ARF signaling to p53 [PDF]

Proceedings of the National Academy of Sciences, 2004
Activation of the ARF–p53 tumor suppressor pathway is one of the cell's major defense mechanisms against cancer induced by oncogenes. The ARF–p53 pathway is dysfunctional in a high proportion of human cancers. The regulation of the ARF–p53 signaling pathway has not yet been well characterized.
Madeleine G, Moule, Crista H, Collins, Frank, McCormick, Mike, Fried   +3 more
openaire   +2 more sources

Glycosylated dendrimer nanoamplifiers hijack DNA damage‐immune crosstalk for enhanced dual‐track therapy of orthotopic glioblastoma

BMEMat, EarlyView.
A glycosylated dendrimer nanoamplifier hijacks DNA damage‐immune crosstalk for enhanced radio‐immunotherapy of glioblastoma. The responsive release of demethylcantharidin simultaneously blocks repair‐mediated resistance by inhibiting DNA repair and overcomes adaptive immune resistance.
Cong Song, Binghan Liu, Junjie Liu, Ce Li, Wenqing Man, Xurui Sun, Chang Yuan, Yanjun Wang, Hong Pan, Shuanglian Wang, Zhiming Zheng   +10 more
wiley   +1 more source

Real-time PCR to detect the mRNA levels for the regulatory subunits of PP2A-Aα, PP2A-Aβ, PP2A-Bα, PP2A-Bβ, and PP2A-Bγ in the retina, lens epithelium, lens fiber, and cornea of the mouse eye

, 2011
Real-time PCR procedures are described in the Methods section. The primers used in this study are listed in . Note that the real-time results confirm the RT–PCR patterns of mRNA levels for the regulatory subunits of PP2A-Aα, PP2A-Aβ, PP2A-Bα, PP2A-Bβ ...
David Wan-Cheng Li (90955), He-Ge Chen (90952), Shuming Sun (90953), Yun Liu (84346), Yong Li (15029), Jin-Ping Liu (90954), Wen-Bin Liu (90950), Lan Zhang (90951)   +7 more
core   +1 more source

Anticancer potential of berberine: Molecular pathways and current clinical trial perspectives

JSFA reports, EarlyView.
Abstract Cancer is constantly rising mortality rates due to its late prognosis, poor management, and expensive treatment. Multi‐sectoral approaches for cancer management include hygienic practices, synthetic drug exploitation, radiation therapy, and diet modifications.
Muhammad Maaz, Muhammad Tauseef Sultan, Muhammad Israr, Waqas Ahmad Khan, Fahad Tanveer, Muzzamal Hussain, Muhammad Imran, Ahmed Mujtaba, Anjuman Gul Memon, Muhammad Atif, Entessar Al Jbawi   +10 more
wiley   +1 more source

MpPP2A-A gene cloning and knockout mutant constructing in Marchantia polymorpha

Guangxi Zhiwu
Protein phosphatase 2A(PP2A), a serine/threonine phosphatases, participates in many biological processes such as plant growth and development by dephosphorylating its substrate proteins.
LIU Wenzhen1,2,3, JIANG Xinhua1,2, ZHANG Bangyue1,2, CHEN Sha1,2, ZHANG Jingjing1,2, LI Xiangyuan1,2, RONG Duoyan1,2,3*
doaj   +1 more source

PP2AC Phospho-Tyr307 Antibodies Are Not Specific for this Modification but Are Sensitive to Other PP2AC Modifications Including Leu309 Methylation

Cell Reports, 2020
Summary: Protein phosphatase 2A (PP2A) is an important regulator of signal transduction pathways and a tumor suppressor. Phosphorylation of the PP2A catalytic subunit (PP2AC) at tyrosine 307 has been claimed to inactivate PP2A and was examined in more ...
Ingrid E. Frohner, Ingrid Mudrak, Stefan Schüchner, Dorothea Anrather, Markus Hartl, Jean-Marie Sontag, Estelle Sontag, Brian E. Wadzinski, Teresa Preglej, Wilfried Ellmeier, Egon Ogris   +10 more
doaj   +1 more source