Results 81 to 90 of about 35,429 (234)
Structure and Function of the PP2A-Shugoshin Interaction [PDF]
Molecular Cell, 2009 Accurate chromosome segregation during mitosis and meiosis depends on shugoshin proteins that prevent precocious dissociation of cohesin from centromeres. Shugoshins associate with PP2A, which is thought to dephosphorylate cohesin and thereby prevent cleavage by separase during meiosis I.
Xu, Z +6 more
openaire +3 more sources
Phytotherapy Research, EarlyView.Rh1 attenuates oxidative stress and mitochondrial dysfunction through SIRT1‐related signaling. ABSTRACT Alzheimer's disease (AD) remains a progressive neurodegenerative disorder with limited therapeutic options. Ginsenoside Rh1 has been reported to possess neuroprotective properties, yet its specific role and underlying mechanisms in AD are not fully ...
Shi‐Lu Li +10 more
wiley +1 more source
STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells
eLife, 2020 Alterations involving serine-threonine phosphatase PP2A subunits occur in a range of human cancers, and partial loss of PP2A function contributes to cell transformation.
Jong Wook Kim +16 more
doaj +1 more source
Visible phenotypes of representative pp2a mutants.
, 2013 a) Representative plants of WT and early flowering mutant lines pp2a-bα (SALK_09504) and pp2a-bβ (SALK_062614). b) Mutant line pp2a-b’γ complemented with 35S::PP2A-B’γ showing flowering time as WT, late flowering line b’γ (SALK_039172), and WT plants ...
Dugassa Nemie-Feyissa (585751) +3 more
core +1 more source
Environmental Toxicology, EarlyView.ABSTRACT Veterinary medicines, which reach the soil mostly through the application of contaminated manures, can affect beneficial soil microorganisms, such as nitrogen‐fixing rhizobia bacteria, which engage in important symbiotic associations with plants.
Polyxeni Gorgia +6 more
wiley +1 more source
The Role of PP2A A Subunits in Tumor Suppression [PDF]
Cell Adhesion & Migration, 2007 The protein phosphatase 2A (PP2A) family of heterotrimeric serine-threonine phosphatases participates in human cell transformation. Each functional PP2A complex contains one structural A subunit (A alpha or A beta), and mutations of both are found to occur at low frequency in human tumors. We have shown that A alpha functions as haploinsufficient tumor
Anna A, Sablina, William C, Hahn
openaire +2 more sources
DMH1 induces Akt activation through inhibiting PP2A in L6 cells.
, 2014 (A) DMH1 treatment showed no effect on the protein expressions of PP2A-a, PP2A-b, and PP2A-c subunits.
Xin Xie (311744) +6 more
core +1 more source
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Obstructive sleep apnea is a clinical syndrome that triggers a series of pathophysiologic changes, including disturbed sleep architecture, chronic intermittent hypoxia and hypercapnia, and ultimately severe cognitive dysfunction. The hippocampus plays a key role in various cognitive processes such as learning and memory.
Rui Fan, Tao Li, Yan Yan
wiley +1 more source
Long Non‐Coding RNA, Like NEAT1 and MALAT1, in Asthma: Mechanisms and Therapeutic Potential
Clinical &Experimental Allergy, EarlyView.Long non‐coding RNA, like NEAT1 and MALAT1, is emerging as a regulator of asthma‐related inflammation, airway remodelling, viral responses and cell death pathways, and are promising targets for future therapeutics. ABSTRACT Asthma affects millions worldwide. Long non‐coding RNA (lncRNA) are emerging as important factors in the pathophysiology of asthma
Ashlyn Poole +4 more
wiley +1 more source
Defects of protein phosphatase 2A causes corticosteroid insensitivity in severe asthma. [PDF]
PLoS ONE, 2011 BACKGROUND: Corticosteroid insensitivity is a major barrier of treatment for some chronic inflammatory diseases, such as severe asthma, but the molecular mechanism of the insensitivity has not been fully elucidated.
Yoshiki Kobayashi +3 more
doaj +1 more source