Results 101 to 110 of about 35,429 (234)
PP2A, the Key to Life and Death
, 2011 By recruiting active protein phosphatase 2A (PP2A) complexes or a PP2A inhibitor, the UNC5H2 dependence receptor triggers death or survival, respectively.
Nancy R. Gough
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Journal of Biomedical Materials Research Part A, Volume 114, Issue 11, November 2026.ABSTRACT Hydrocalumite‐like phases, belonging to the layered double hydroxide family, are potential biomaterials for bone repair; however, their cellular effects remain incompletely understood. Here, we evaluated a hydrocalumite‐like material of composition [Ca2Al(OH)₆]Cl·nH2O (abbreviated Ca2Al–Cl) in preosteoblastic MC3T3‐E1 cells, assessing ...
C. J. da Costa Fernandes +4 more
wiley +1 more source
Flowering time for WT, pp2a-bα, pp2a-bβ and pp2a-b’γ lines grown in 8, 12, 16 or 24 h days.
, 2013 a) Days until first bud (green columns) and first flower (white columns) for WT, pp2a-bα (SALK_09504), pp2a-bβ (SALK_062614) in 12 h and 24 h days. b) Days until first bud (green columns) or first flower (white columns) for WT, pp2a-bα (SALK_032080 ...
Dugassa Nemie-Feyissa (585751) +3 more
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Polyomavirus Drives Cerebellar Lesions in AIDS Monkeys With Ataxia
MedComm, Volume 7, Issue 11, November 2026.Chronic SIV‐infected macaques with ataxia develop severe cerebellar lesions driven by simian polyomavirus 40 (SV40) infection. SV40 preferentially infects cerebellar granule cells, inducing pyroptosis and an aberrant proliferative state. Pyroptotic neuronal injury promotes microglial recruitment and activation, amplifying local neuroinflammation and ...
Tian‐Zhang Song +9 more
wiley +1 more source
Aging Cell, Volume 25, Issue 11, November 2026.This review examines how histone modifications integrate aging, metabolic dysfunction and neuroinflammation to shape persistent, cell‐type‐specific chromatin states in Alzheimer's disease. By distinguishing causal regulation from association through perturbation, persistence and reversibility, it highlights metabolic–epigenetic feedback loops and ...
Junyi Liang +7 more
wiley +1 more source
Plant, Cell &Environment, Volume 49, Issue 11, Page 8521-8539, November 2026.ABSTRACT Plant‐fungus‐virus tripartite interactions represent complex ecological systems in which mutualistic endophytes can influence host physiology, yet the molecular basis of endophyte‐mediated defence remains poorly understood. Here, we demonstrate that the endophytic fungus Penicillium pinophilum EU0013 suppresses the yellow strain of cucumber ...
Sarah R. Ibiang +3 more
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In vivo demethylation of sperm PP2A.
, 2015 (A) Caudal sperm were incubated with 1 mM each of L-Homocysteine and Adenosine (L-Hcy + Ado), 1 mM L- Homocysteine (L-Hcy) or 1 mM adenosine (Ado) for 10 min. Sperm extracts were prepared by sonication and analyzed by western blot (2X106 sperm/lane) with
John K. Ferrara (827362) +4 more
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Progressive Parkinsonism in PPP2R5D‐Related Neurodevelopmental Disorder
Annals of Clinical and Translational Neurology, Volume 13, Issue 10, Page 2161-2165, October 2026.ABSTRACT PPP2R5D‐related neurodevelopmental disorder (Houge–Janssens syndrome type 1) is a rare autosomal dominant condition characterized by macrocephaly, intellectual disability, and epilepsy. Progressive parkinsonism is an emerging adult phenotype that neurologists should be aware of since timely genetic diagnosis opens the door to disease‐modifying
Katerina Bernardi +6 more
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Methylation-regulated decommissioning of multimeric PP2A complexes
, 2017 Dynamic assembly/disassembly of signaling complexes are crucial for cellular functions. Specialized latency and activation chaperones control the biogenesis of protein phosphatase 2A (PP2A) holoenzymes that contain a common scaffold and catalytic ...
Yongna Xing +11 more
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Purification and Characterization of the B55α/PP2A Holoenzye [PDF]
, 2018 Protein Phosphatase 2A (PP2A) is a holoenzyme consisting of three subunits – a scaffold subunit (A), a catalytic subunit (C), and a regulatory subunit (B).
Feiser, Felicity
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