Results 111 to 120 of about 35,429 (234)

Microprotein MP104 Promotes Malignant Progression of Colorectal Cancer Through Regulating Protein Translation

Advanced Science, Volume 13, Issue 56, 9 October 2026.
A previously unrecognized microprotein, MP104, encoded by ZEB1‐AS1, emerges as a critical driver of colorectal cancer progression. MP104 links ubiquitin‐mediated protein degradation with translational reprogramming via the UBE2O–AMPKα2–mTOR–EIF4B axis, revealing an unrecognized layer of oncogenic regulation.
Fang Chen, Miao Wang, Hongmei Yong, Jin Ding, Shiping Xu, Qirui Ge, Yan Wang, Lei Zhang, Qianqian Xiao, Benli Li, Li Lin, Sufang Chu, Qianqing Wang, Jin Bai, Pingfu Hou   +14 more
wiley   +1 more source

Cerebral endothelial 3-mercaptopyruvate sulfurtransferase improves ischemia-induced cognitive impairment via interacting with protein phosphatase 2A

Acta Pharmaceutica Sinica B
The catalytic activity of 3-mercaptopyruvate (3MP) sulfurtransferase (MPST) converts 3MP to hydrogen sulfide (H2S). However, the regulatory mechanisms governing MPST and its impact on the brain remain largely unexplored.
Li Zhu, Yi Huang, Jing Jin, Rongjun Zou, Rui Zuo, Yong Luo, Ziqing Song, Linfeng Dai, Minyi Zhang, Qiuhe Chen, Yunting Wang, Wei Wang, Rongrong He, Yang Chen   +13 more
doaj   +1 more source

Targeting PP2A in cancer: Combination therapies

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2019
The serine/threonine phosphatase PP2A regulates a vast portion of the phosphoproteome including pathways involved in apoptosis, proliferation and DNA damage response and PP2A inactivation is a vital step in malignant transformation. Many groups have explored the therapeutic venue of combining PP2A reactivation with kinase inhibition to counteract the ...
Sahar, Mazhar, Sarah E, Taylor, Jaya, Sangodkar, Goutham, Narla   +3 more
openaire   +2 more sources

Rules for PP2A-controlled phosphosignalling and drug responses

, 2018
Systemic understanding of protein phosphatase 2A (PP2A)-regulated cellular processes is still at infancy. Here, we present mass-spectrometry analysis of phospho-targets (dephosphorylome) regulated by PP2A modulation.
Luyao Ruan, Laxman Yetukuri, Anni Laine, Evgeny Kulesskiy, Pekka Haapaniemi, Jukka Westermarck, Bhagwan Yadav, Otto Kauko, Garry Corthals, Jüri Reimand, Taru Varila, Susumu Y. Imanishi, Tero Aittokallio, Mikael Jumppanen, Veronika Suni, Krister Wennerberg, Teemu Daniel Laajala   +16 more
core   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, Volume 13, Issue 60, 28 October 2026.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

Protein phosphatase 2A (PP2A): a key phosphatase in the progression of chronic obstructive pulmonary disease (COPD) to lung cancer

Respiratory Research, 2019
Lung cancer (LC) has the highest relative risk of development as a comorbidity of chronic obstructive pulmonary disease (COPD). The molecular mechanisms that mediate chronic inflammation and lung function impairment in COPD have been identified in LC ...
Cassandra P. Nader, Aylin Cidem, Nicole M. Verrills, Alaina J. Ammit   +3 more
doaj   +1 more source

Memantine restores PP2A activity by decreasing the demethylation of PP2Ac at Leu 309.

, 2016
A, B) Western blots developed with mouse anti-PP2A catalytic α (1:10000; BD Transduction Laboratories™) showed no significant change in the level of PP2Ac in the AAV1-I1PP2A rat brain when compared with AAV1-GFP control group and treatment with memantine
Xiaochuan Wang (550306), Inge Grundke-Iqbal (21083), Khalid Iqbal (21084), Julie Blanchard (701839)   +3 more
core   +1 more source

Hypothetical scheme showing how I₁^PP2A inhibits PP2A activity and memantine rescues it.

, 2016
A) I1PP2A on the one hand interacts with the catalytic subunit of PP2A (PP2Ac) and inhibits the PP2A activity [8]. On the other hand, I1PP2A probably upregulates the methylesterase PME, and/or downregulates the leucine carboxyl methyltransferase LCMT1 ...
Xiaochuan Wang (550306), Inge Grundke-Iqbal (21083), Khalid Iqbal (21084), Julie Blanchard (701839)   +3 more
core   +1 more source

Corynoxine Inhibits Tumor Growth via Targeting NQO1 and Modulating the PTPA–NQO1/PP2A Switch to Activate PP2A (Adv. Sci. 60/2026)

Advanced Science, Volume 13, Issue 60, 28 October 2026.
Corynoxine Inhibits Tumor Growth The cover depicts corynoxine entering tumor cells and targeting NQO1 to weaken the NQO1‐PTPA association, thereby facilitating PTPA association with PP2Ac and activating PP2A. This molecular switch disrupts tumor‐promoting signals and ultimately suppresses tumor cell survival and proliferation. More details can be found
Guoqing Hou, Li Lin, Mengjie Xia, Ruohan Liang, Yueyue Zhang, Linna Du, Xuan Cao   +6 more
wiley   +1 more source

PP2A is critical for SARI-modulated GSK-3β-β-catenin signaling and EMT.

, 2012
(A) SARI complexes are associated with both GSK3β and PP2A. GLC-82 cells were transfected with control vector (VC) or SARI. Cell lysates were immunoprecipitated with GSK-3β, PP2A, and SARI antibodies and then probed with Flag and PP2A or GSK3β antibodies,
Xiaoliang Zhao (134512), Zhenfa Zhang (134514), Jian You (134510), Changli Wang (134507), Meng Wang (124646), Lianmin Zhang (134509), Jun Liu (42548), Yanjun Su (134508), Xishan Hao (85794)   +8 more
core   +1 more source