Results 131 to 140 of about 35,429 (234)

Infection mechanisms of Rhizoctonia cerealis in wheat

iMeta, Volume 5, Issue 5, October 2026.
We discover that R. cerealis (Rc) is a primary pathogen causing sharp eyespot of wheat after 335 distinct isolates were isolated from 1683 SE‐diseased wheat plants across China over 7 years using a single hyphal tip isolation method. We then generated high‐quality reference genomes via de novo sequencing of five representative Rc isolates and ...
Yan Ren, Ti Liu, Heying Zhao, Qirun Qian, Lufei Cui, Zhipeng Sun, Wenkai Yang, Peng Guo, Sisheng Wang, Lingran Zhang, Congwei Sun, Aolin Jia, Ning Zhang, Feng Chen   +13 more
wiley   +1 more source

Effects of simvastatin on PP2A activation in porcine coronary artery.

, 2013
(A) Effects of simvastatin (10 μM) on the protein expression of p-PP2A/total PP2A in porcine coronary artery ...
Yiu Wa Kwan (362888), Siu Kai Kong (422495), Simon Ming Yuen Lee (362891), Ho Pui Ho (422498), Shun Wan Chan (362889), George Pak Heng Leung (362890), Sai Ming Ngai (422496), Song Wan (422497), Alice Lai Shan Au (422492), John Hok Keung Yeung (182813), Maggie Pui Man Hoi (362887), Rachel Wai Sum Li (422494), Christina Chui Wa Poon (422493), Sai Wang Seto (384961), Qian Zhang (49333)   +14 more
core   +1 more source

SIRT3‐Dependent Actions of Berberine: From Molecular Therapies to Toxicity

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
This study reveals that berberine's therapeutic versatility in metabolic, cardiovascular, and hepatic disorders stems from its modulation of the mitochondrial protein Sirt3. Understanding this mechanism explains both its broad efficacy and its organ‐specific toxicity, positioning berberine as a promising mitochondrial epigenetic modulator whose ...
Dareuosh Shackebaei, Seyed Shahram Miraghaee, Faegheh Farhadi, Abolfazl Akbarzadeh, Fatemeh Yarmohammadi   +4 more
wiley   +1 more source

Functional interaction between SIK2 and PP2A

, 2013
SIK2是屬於AMPK家族，SIK次家族的一員。AMPK家族的成員主要功能在於偵測細胞能量狀態，對於細胞凋亡以及自噬作用的逆境反應。在AMPK家族中，SIK2是唯一可以與PP2A及VCP/P97有交互作用的成員。然而，對於SIK2-PP2A複合體的功能仍然不清楚。在癌細胞中，SIK2的降解在泛素蛋白質體降解系統及自噬作用中扮演重要角色。SIK2 knockdown會造成PP2Ac量的下降，並且會增加Bcl-2/S70的磷酸化。我發現PME-1/S15的磷酸化在SIK2 knockdown時會上升 ...
Lee, Chia-Wei, 李家瑋
core  

Electrical Pulse Stimulation Partially Restores Insulin Signaling in Palmitate‐Induced Insulin‐Resistant Skeletal Muscle Cells via Mitochondrial Remodeling and Contractile Activity‐Dependent Secretome

Journal of Cellular Physiology, Volume 241, Issue 10, October 2026.
ABSTRACT Lipid oversupply induces insulin resistance in skeletal muscle (SkM), partly by altering mitochondrial function and dynamics. Although electrical pulse stimulation (EPS) improves insulin signaling in myotubes, the mechanisms contributing to this effect under lipotoxic conditions remain unclear.
Alessandro Falcone, Sevgican Yilmaz, Mona Hendlinger, Patrick Schrauwen, Polina Lipaeva, Marlene Piribauer, Geronimo Heilmann, Sandra Trenkamp, Michael Roden, Lucia Mastrototaro   +9 more
wiley   +1 more source

Altering phosphorylation in cancer through PP2A modifiers

Cancer Cell International
Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase integral to the regulation of many cellular processes. Due to the deregulation of PP2A in cancer, many of these processes are turned toward promoting tumor progression. Considerable research
Hannah Johnson, Satya Narayan, Arun K. Sharma   +2 more
doaj   +1 more source

The Sleeping Giant: Metabolism and Autophagy in the Generation and Survival of Dormant Polyploid Giant Cancer Cells

MedComm, Volume 7, Issue 10, October 2026.
Polyploid giant cancer cells (PGCCs) arise in response to stress and play a critical role in therapy resistance and tumor dormancy. These cells can evade conventional treatments and later contribute to cancer relapse by generating progeny through nonmitotic, amitotic mechanisms.
Silvia Guil‐Luna, María Teresa Sánchez‐Montero, Alejandra Díaz‐Chacón, Antonio Rodríguez‐Ariza   +3 more
wiley   +1 more source

Ischemic Stroke and Traumatic Brain Injury: Epidemiology, Molecular Pathways, and Emerging Therapies

MedComm, Volume 7, Issue 10, October 2026.
Schematic overview of secondary brain injury after ischemic stroke and traumatic brain injury. Both conditions trigger endothelial cell dysfunction, pericyte contraction, and upregulated AQP4 expression in astrocytic end‐feet, leading to blood–brain barrier disruption.
Mengzhao Feng, Qi Qin, Fang Wang, Kaiyuan Zhang, Zhihua Li, Junlei Chang, Min Yu, Fuyou Guo   +7 more
wiley   +1 more source

Cyanopeptide Mixtures Induce Variable Synergistic and Antagonistic Effects Across Diverse Human Cell Lines

Environmental Toxicology, Volume 41, Issue 10, Page 807-821, October 2026.
ABSTRACT Cyanobacterial harmful algal blooms (cyanoHABs) threaten human, animal, and ecosystem health and safety through production of toxic secondary metabolites. Microcystis, a cosmopolitan bloom‐forming cyanobacterial genus, is well‐known for producing hepatotoxic microcystins (MCs), but it can produce many other bioactive cyanopeptides, such as ...
Lauren N. Hart, Katherine L. Lev, Sierra Hefferan, Sanduni H. Premathilaka, Sharmila I. Thenuwara, Dragan Isailovic, David H. Sherman, Gregory J. Dick   +7 more
wiley   +1 more source

Pharmacological Reactivation of PP2A by SET/CIP2A Inhibition Attenuates Triple Negative Breast Cancer Progression

Kinases and Phosphatases
The tumor suppressor protein phosphatase 2A (PP2A) plays a crucial role in regulating oncogenic signaling. Its inactivation, specifically through inhibitory phosphorylation at Tyr307 mediated by SET and CIP2A, contributes to breast cancer (BC ...
Gustavo Adolfo Barraza, Joselina Magali Mondaca, Juan Manuel Fernandez Muñoz, Bruno Mariano Vinante, Marina Inés Flamini, Angel Matias Sanchez   +5 more
doaj   +1 more source