Results 141 to 150 of about 35,429 (234)

Sodium Butyrate Attenuates Renal Fibrosis by Regulating Glycolysis and Histone H4K12 Lactylation in Diabetic Kidney Disease

Diabetes, Obesity and Metabolism, Volume 28, Issue 10, Page 9518-9534, October 2026.
ABSTRACT Background The role of histone lactylation in diabetes associated renal fibrosis remains poorly defined. In this study, we investigated the contribution of histone H4 lysine 12 lactylation (H4K12la) to abnormal glycolysis and renal fibrogenesis in diabetic kidney disease (DKD) and evaluated sodium butyrate (NaB) as a potential therapeutic ...
Ping He, Mingxiu Wang, Hang Mei, Yue Liu, Min Wang, He Sun, Yali Peng, Xuan Ban, Yue Wang, Xiaofang Tang, Qiuling Fan   +10 more
wiley   +1 more source

The preprophase band is dispensable for robust cell division orientation in wood‐forming cambium stem cells

New Phytologist, Volume 252, Issue 1, Page 178-191, October 2026.
Characterization of periclinal and anticlinal cell divisions in dividing cambium stem cells (CSCs). (a) Scheme indicating periclinal and anticlinal cell divisions in CSCs in the Arabidopsis hypocotyl. The orange dashed ring in the middle panel represents the cambium area. The orange cuboids represent individual CSCs.
Xiaomin Liu, Pantelis Livanos, Laura Sophie Schütz, Sabine Müller, Thomas Greb   +4 more
wiley   +1 more source

NLP6/7‐mediated nitrate signaling facilitates high‐affinity potassium uptake and enhances tolerance to low potassium environments in Arabidopsis

The Plant Journal, Volume 128, Issue 1, October 2026.
SUMMARY Balancing the acquisition of the macronutrients nitrogen (N) and potassium (K) is critical for plant growth, yet the mechanisms that balance N and K acquisition remain poorly understood. Here, we show that the NIN‐LIKE PROTEIN7 (NLP7) transcription factor, which mediates nitrate signaling, plays a crucial role in promoting K acquisition in ...
Kosuke Usuda, Mailun Yang, Namie Ohtsuki, Nana Sugimura, Daiki Teshima, Yasuhito Sakuraba, Shuichi Yanagisawa   +6 more
wiley   +1 more source

Sirtuin signalling governs calcium homeostasis and mitochondrial function in metabolic syndrome cardiomyocytes

Experimental Physiology, Volume 111, Issue 10, Page 4646-4658, 1 October 2026.
Abstract Metabolic syndrome (MetS) is a major contributor to cardiovascular disease and is characterized by impaired Ca2+ handling and mitochondrial dysfunction in cardiomyocytes. However, the upstream mechanisms linking metabolic stress to these alterations remain incompletely defined.
Firat Akat, Leila Aryan, Suatnur Şık, Erkan Tuncay   +3 more
wiley   +1 more source

Physiological Changes and PP2A-C Expression Modulated by Waterlogging Conditions Are Organ-Specific in Tomato Seedlings

Agronomy
Waterlogging stress leads to a reduction in the oxygen level around the root system (hypoxia). It can be caused by poor air exchange in flooded or compacted soil or in a non-aerated medium.
Anna Kołton, Monika A. Czaja, Maria T. Creighton, Cathrine Lillo, Alina Wiszniewska, Małgorzata Czernicka, Kamil Szymonik   +6 more
doaj   +1 more source

PP2A B’’-subunits and their tissue distribution.

, 2014
PP2A B’’-subunits and their tissue distribution.
Pär Nordlund (161768), Susan Tsutakawa (595189), Christian Löw (320481), Madhanagopal Anandapadamanaban (595190), Esben M. Quistgaard (444925), Rebecca Dovega (595188)   +5 more
core   +1 more source

A PP2A molecular glue overcomes RAS/MAPK inhibitor resistance in KRAS-mutant non–small cell lung cancer

The Journal of Clinical Investigation
The effectiveness of RAS/MAPK inhibitors in treating metastatic KRAS-mutant non–small cell lung cancer (NSCLC) is often hindered by the development of resistance driven by disrupted negative feedback mechanisms led by phosphatases like PP2A.
Brynne Raines, Stephanie Tseng-Rogenski, Amanda C. Dowdican, Irene Peris, Matthew Hinderman, Kaitlin P. Zawacki, Kelsey Barrie, Gabrielle Hodges Onishi, Alexander M. Dymond, Tahra K. Luther, Sydney Musser, Behirda Karaj Majchrowski, J. Chad Brenner, Aqila Ahmed, Derek J. Taylor, Caitlin M. O’Connor, Goutham Narla   +16 more
doaj   +1 more source

Effect of PP2A inhibition on LTD expression.

, 2016
Effect of PP2A inhibition on LTD expression.
Radu Calinescu (848105), A. Radu Aricescu (208528), Michisuke Yuzaki (121827), Andrew R. Gallimore (848104)   +3 more
core   +1 more source

Cigarette smoke alters calcium flux to induce PP2A membrane trafficking and endothelial cell permeability

Scientific Reports
Alveolar capillary barrier disruption induces local edema and inflammation that impairs pulmonary function and promotes alveolar destruction in COPD. This study aimed to determine how cigarette smoke modulated the serine-threonine phosphatase protein ...
Abdoulaye J. Dabo, Sonya Raghavan, Wendy Ezegbunam, Jincy Thankachen, Oleg Evgrafov, Sue Majka, Patrick Geraghty, Robert F. Foronjy   +7 more
doaj   +1 more source

Novel PP2A-Activating Compounds in Neuroblastoma

Background: Neuroblastoma (NB) remains one of the deadliest pediatric solid tumors. Recent advancements aimed at improving outcomes have been insufficient, and patients with high-risk NB continue to have a poor prognosis. Protein phosphatase 2A (PP2A) is
Janet R. Julson, Michael Ohlmeyer, Laura V. Bownes, Elizabeth A. Beierle, Hooper R. Markert, Michael H. Erwin, Karina J. Yoon, Jamie Aye, Sorina Shirley, Colin H. Quinn, Raoud Marayati, Nazia Nazam, Jerry E. Stewart   +12 more
core   +1 more source