Results 121 to 130 of about 35,429 (234)
Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.Abstract The neuromodulatory subcortical system (NSS) includes thermoregulatory neurons that maintain core body temperature (Tb) and brain temperature within a narrow, diurnally varying range. Cellular pathways in NSS neurons implicated in Alzheimer's disease (AD) may be vulnerable to Tb rhythm disturbance because of their sensitivity to temperature ...
Esther Blessing
wiley +1 more source
Journal of Inflammation ResearchWenjuan Yi,1 Qionglin Bao,2 Dingkun Xu,3 Chenyu Long,1 Ruixin Fang,1 Wenlin Cheng,4 Jiquan Song,1 Huiting Feng1 1Department of Dermatology, Zhongnan Hospital of Wuhan University, Wuhan, People’s Republic of China; 2Wound Repair Center, Chronic Wound and ...
Yi W +7 more
doaj
Presence of PP1γ, PP2B, and PP2A in human sperm.
, 2013 Twenty-microgram samples of sperm extracts were subjected to SDS-PAGE and then transferred onto a PVDF membrane. The membrane was then probed with anti PP1γ (PP1γ), anti-PP2Bα (PP2B), and with an antibody sampler kit anti PP2A (PP2Ac, PP2A-A, PP2A-B ...
Patricio Morales (491557) +4 more
core +1 more source
ANALYSES OF THE SCAFFOLD SUBUNIT OF THE HETEROTRIMERIC PHOSPHATASE PP2A IN ASSEMBLING THE CENTRIOLE STRUCTURE [PDF]
, 2022 Centrioles are organelles conserved in all eukaryotes that have cilia or flagella. They consist of nine-triplet microtubules arranged in rotational symmetry, which is composed of more than 200 proteins.
内藤 紗花
core
Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.Abstract INTRODUCTION Hyperphosphorylated Tau accumulation drives neurodegeneration in Alzheimer's disease (AD), but mechanisms linking impaired Tau ubiquitination to disease progression remain incompletely defined. METHODS We integrated Drosophila RNAi screening, human AD datasets, cellular assays, and mouse tauopathy models to evaluate arrestin ...
Jiaqi Liu +6 more
wiley +1 more source
Epilepsia, Volume 67, Issue 10, Page 5042-5074, October 2026.Abstract Over the last 34 years, the Eilat Conference on New Antiepileptic Drugs and Devices has provided an interactive forum for stakeholders to discuss investigational and recently licensed treatments for seizures and epilepsy. The Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII) took place in Madrid, Spain, on May 3 ...
Meir Bialer +7 more
wiley +1 more source
Microcystin-LR (MCLR) Induces a Compensation of PP2A Activity Mediated by α4 Protein in HEK293 Cells
International Journal of Biological Sciences, 2011 Protein phosphatase 2A (PP2A) is a major protein phosphatase with important cell functions. Known and utilized as a potent inhibitor of PP2A, microcystin-LR (MCLR) targets PP2A as a core element that affects numerous cellular mechanisms.
Tan Li, Pu Huang, Jing Liang, Wenyu Fu, Zonglou Guo, Lihong Xu
doaj
PP2A-Mediated Anticancer Therapy
, 2020 PP2A is a family of mammalian serine/threonine phosphatases that is involved in the control of many cellular functions including protein synthesis, cellular signaling, cell cycle determination, apoptosis, metabolism, and stress responses through the ...
Yitao Ding +3 more
core
iMeta, Volume 5, Issue 5, October 2026.The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li +29 more
wiley +1 more source
Caspase-3 mediates PP2A-related AKT dephosphorylation.
, 2013 A. Different cells were pre-incubated with indicated concentrations of OA for 1 h and exposed to ATO for 48 h, then lysed in NP40 buffer for detection. Western blot analysis of total AKT and p-AKT (Ser473) levels was shown.
Chunlai Nie (350669) +6 more
core +1 more source