Results 91 to 100 of about 35,429 (234)

Epigallocatechin gallate restores the reduction of protein phosphatase 2 A subunit B caused by middle cerebral artery occlusion

Laboratory Animal Research, 2023
Background Epigallocatechin gallate (EGCG) is a flavonoid compound commonly found in green tea. It exhibits antioxidant, anti-inflammatory, and neuroprotective effects in cerebral ischemia.
Murad-Ali Shah, Ju-Bin Kang, Dong-Ju Park, Phil Ok Koh   +3 more
doaj   +1 more source

Targeting CKIP‐1 for Disease Therapy: Cellular Functions, Molecular Networks, and Clinical Potential

Cell Proliferation, EarlyView.
CKIP‐1, as a scaffold protein with special structural domains, treats related diseases through multiple emerging targeted technologies.
Xin Huang, Shijie Lv, Lejia Li, Jirong Xie, Zhengguo Cao   +4 more
wiley   +1 more source

From the biology of PP2A to the PADs for therapy of Hematologic malignancies

Frontiers in Oncology, 2015
Over the past decades, an emerging role of phosphates in the pathogenesis of hematologic malignancies and solid tumors has been established. The tumor suppressor Protein phosphatase 2A (PP2A) belongs to the serine-threonine phosphatases family and ...
Maria eCiccone, George eCalin, Danilo ePerrotti   +2 more
doaj   +1 more source

Changes in Carboxy Methylation and Tyrosine Phosphorylation of Protein Phosphatase PP2A Are Associated with Epididymal Sperm Maturation and Motility. [PDF]

PLoS ONE, 2015
Mammalian sperm contain the serine/threonine phosphatases PP1γ2 and PP2A. The role of sperm PP1γ2 is relatively well studied. Here we confirm the presence of PP2A in sperm and show that it undergoes marked changes in methylation (leucine 309), tyrosine ...
Tejasvi Dudiki, Suraj Kadunganattil, John K Ferrara, Douglas W Kline, Srinivasan Vijayaraghavan   +4 more
doaj   +1 more source

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source

Specialized functions of the PP2A subfamily II catalytic subunits PP2A-C3 and PP2A-C4 in the distribution of auxin fluxes and development in Arabidopsis

, 2012
Protein phosphorylation is a key molecular switch used to transmit information in biological signalling networks. The output of these signalling circuits is governed by the counteracting activities of protein kinases and phosphatases that determine the ...
Paredes, Pilar, Rojo, Enique, Enrique Rojo, Teresa Domínguez, Jose J. Sánchez-Serrano, Duprat, Anne, Maite Sanmartín, Michael Sauer, Anne Duprat, Pilar Paredes, Sauer, Michael, Domínguez, Teresa, Ballesteros Redondo, María Isabel, Sanmartín, Maite, Sánchez Serrano, Jose, Isabel Ballesteros   +15 more
core   +1 more source

From Association to Mechanism: Regulatory Annotation and Pathway Mapping of Genes Surrounding Breast Cancer Risk Variants

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Inherited factors account for a large share of breast cancer susceptibility, yet the biological consequences of most risk variants are still poorly understood. To address this gap, we studied 175 breast cancer risk variants confirmed by genome‐wide association studies and gathered the genes that lie near them.
Sultana Jannat, Trina Mitra, Nafisa Nawar Fariha, Tasmia Tabassum, Kulsuma Bahar Bethi, Synchita Majumder Kaya, Md. Arif Hossen, Md. Saad Hossain, Jobaier Ibne Deen, Mohammed Emon, Laila Khaleda, Md. Hridoy Ahmed   +11 more
wiley   +1 more source

Protein Phosphatase 2A Negatively Regulates Eukaryotic Initiation Factor 4E Phosphorylation and eIF4F Assembly through Direct Dephosphorylation of Mnk and eIF4E

Neoplasia: An International Journal for Oncology Research, 2010
The eukaryotic translation initiation factor 4E (eIF4E) is frequently overexpressed in human cancers and is associated with cellular transformation, tumorigenesis, and metastatic progression. It is known that Mnks can phosphorylate eIF4E.
Yikun Li, Ping Yue, Xingming Deng, Takeshi Ueda, Rikiro Fukunaga, Fadlo R. Khuri, Shi-Yong Sun   +6 more
doaj   +1 more source

The novel regulatory influence of Argonaute 1 on messenger RNA 5‐methylcytosine modification in Arabidopsis thaliana

The Plant Genome, Volume 19, Issue 4, December 2026.
Abstract 5‐Methylcytidine (m5C) modifications play a critical role in RNA metabolism. TRM4B (tRNA‐specific methytransferase 4B) is the only known component of the plant m5C machinery that mediates mRNA (messenger RNA) methylation. To date, no regulators governing site‐specific m5C modifications have been identified, apart from several degenerated ...
Zedi Feng, Xiu Yin, Zhifang Jiang, Jia Yao, Yiling Dong, Xiaoxia Ma, Yijun Meng   +6 more
wiley   +1 more source

A Nonhomologous End-joining Pathway Is Required for Protein Phosphatase 2A Promotion of DNA Double-Strand Break Repair

Neoplasia: An International Journal for Oncology Research, 2009
Protein phosphatase 2A (PP2A) functions as a potent tumor suppressor, but its mechanism(s) remains enigmatic. Specific disruption of PP2A by either expression of SV40 small tumor antigen or depletion of endogenous PP2A/C by RNA interference inhibits Ku ...
Qinhong Wang, Fengqin Gao, Ton Wang, Tammy Flagg, Xingming Deng   +4 more
doaj   +1 more source