Cancerous inhibitor of protein phosphatase 2A (CIP2A) modifies energy metabolism via 5′ AMP-activated protein kinase signalling in malignant cells [PDF]
, 2019 Cancerous inhibitor of protein phosphatase 2A (CIP2A) is an adverse biomarker across many malignancies. Using K562 cells engineered to have high or low CIP2A expression, we show that high CIP2A levels significantly bias cellular energy production towards
Clark, Richard E. +13 more
core +1 more source
Crystallization of the Aα subunit of protein phosphatase 2A [PDF]
Protein Science, 1996 AbstractThe Aα subunit of human protein phosphatase 2A forms crystals in space group P21 with cell dimensions a = 104.0, b = 174.9, c = 168.2 Å, and β angle = 90.2°. At cryogenic temperatures, the crystals diffracted to a resolution limit of ∼ 3.0 Å.
M O, Skidmore +6 more
openaire +2 more sources
Generation of active protein phosphatase 2A is coupled to holoenzyme assembly. [PDF]
PLoS Biology, 2007 Protein phosphatase 2A (PP2A) is a prime example of the multisubunit architecture of protein serine/threonine phosphatases. Until substrate-specific PP2A holoenzymes assemble, a constitutively active, but nonspecific, catalytic C subunit would constitute
Hans Hombauer +6 more
doaj +1 more source
Autoregulation of Protein Phosphatase Type 2A Expression [PDF]
Journal of Biological Chemistry, 1998 Protein phosphatases are involved in many cellular processes. One of the most abundant of these enzymes, the serine/threonine-specific protein phosphatase type 2A (PP2A), is present in most eukaryotic cells and serves a variety of functions. However, the detailed study of its regulation and function has been hampered by the difficulty of manipulating ...
Z, Baharians, A H, Schönthal
openaire +2 more sources
Detection of a protein phosphatase 2A holoenzyme in Neurospora crassa. [PDF]
, 1999 A high molecular mass (about 280 kDa) protein phosphatase 2A holoenzyme was detected in a crude N. crassa extract by gel filtration coupled with phosphatase activity assays. According to Western blot analysis the holoenzyme consists of a 36-kDa catalytic
Yarden, Oded +5 more
core +1 more source
The G-protein-coupled receptor phosphatase: a protein phosphatase type 2A with a distinct subcellular distribution and substrate specificity. [PDF]
, 1995 Phosphorylation of G-protein-coupled receptors plays an important role in regulating their function. In this study the G-protein-coupled receptor phosphatase (GRP) capable of dephosphorylating G-protein-coupled receptor kinase-phosphorylated receptors is
Pitcher, JA +4 more
core +1 more source
Defects of protein phosphatase 2A causes corticosteroid insensitivity in severe asthma. [PDF]
PLoS ONE, 2011 BACKGROUND: Corticosteroid insensitivity is a major barrier of treatment for some chronic inflammatory diseases, such as severe asthma, but the molecular mechanism of the insensitivity has not been fully elucidated.
Yoshiki Kobayashi +3 more
doaj +1 more source
Phosphorylation Promotes the Accumulation of PERIOD Protein Foci
Research, 2023 Circadian clock drives the 24-h rhythm in our behavior and physiology. The molecular clock consists of a series of transcriptional/translational feedback loops operated by a number of clock genes.
Mengna Li, Shujing Li, Luoying Zhang
doaj +1 more source
Functional cdc25C dual-specificity phosphatase is required for S-phase entry in human cells [PDF]
, 2003 In view of the common regulatory mechanism that induces transcription of tie mitotic phosphatase cdc25C and cyclin A at the beginning of S-phase, we investigated whether cdc25C was required for S-phase transit.
Patric Turowski +19 more
core +1 more source
Therapeutic reactivation of protein phosphatase 2A in acute myeloid leukemia
Frontiers in Oncology, 2015 Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase that is required for normal cell growth and development. PP2A is a potent tumor suppressor, which is inactivated in cancer cells as a result of genetic deletions and mutations.
Kavitha eRamaswamy +2 more
doaj +1 more source