Results 41 to 50 of about 327,828 (303)
Free Fatty Acids Inhibit Protein Tyrosine Phosphatase 1B and Activate Akt
Cellular Physiology and Biochemistry, 2013 Background/Aims: Accumulating evidence has suggested that free fatty acids (FFAs) interact with protein kinases and protein phosphatases. The present study examined the effect of FFAs on protein phosphatases and Akt.
Eisuke Shibata +6 more
doaj +1 more source
Generation of active protein phosphatase 2A is coupled to holoenzyme assembly. [PDF]
PLoS Biology, 2007 Protein phosphatase 2A (PP2A) is a prime example of the multisubunit architecture of protein serine/threonine phosphatases. Until substrate-specific PP2A holoenzymes assemble, a constitutively active, but nonspecific, catalytic C subunit would constitute
Hans Hombauer +6 more
doaj +1 more source
Phospho-Akt expression is high in a subset of triple negative breast cancer patients [PDF]
, 2014 The most commonly used biomarkers to predict the response of breast cancer patients to therapy are oestrogen receptor (ER), progesterone receptor (PgR), and human epidermal growth factor receptor 2 (HER2).
Baldacchino, Shawn +6 more
core +1 more source
Frontiers in Genetics, 2023 Cancerous inhibitor of protein phosphatase 2A (CIP2A), initially reported as a tumor-associated antigen (known as p90), is highly expressed in most solid and hematological tumors. The interaction of CIP2A/p90, protein phosphatase 2A (PP2A), and c-Myc can
Beibei Chen +5 more
doaj +1 more source
The protein phosphatase-2A subunit PR130 is involved in the formation of cytotoxic protein aggregates in pancreatic ductal adenocarcinoma cells. [PDF]
Cell Commun SignalAs a major source of cellular serine and threonine phosphatase activity, protein phosphatase-2A (PP2A) modulates signaling pathways in health and disease. PP2A complexes consist of catalytic, scaffolding, and B-type subunits.
Nguyen A +6 more
europepmc +2 more sources
Therapeutic reactivation of protein phosphatase 2A in acute myeloid leukemia
Frontiers in Oncology, 2015 Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase that is required for normal cell growth and development. PP2A is a potent tumor suppressor, which is inactivated in cancer cells as a result of genetic deletions and mutations.
Kavitha eRamaswamy +2 more
doaj +1 more source
Defects of protein phosphatase 2A causes corticosteroid insensitivity in severe asthma. [PDF]
PLoS ONE, 2011 BACKGROUND: Corticosteroid insensitivity is a major barrier of treatment for some chronic inflammatory diseases, such as severe asthma, but the molecular mechanism of the insensitivity has not been fully elucidated.
Yoshiki Kobayashi +3 more
doaj +1 more source
Phosphorylation Promotes the Accumulation of PERIOD Protein Foci
Research, 2023 Circadian clock drives the 24-h rhythm in our behavior and physiology. The molecular clock consists of a series of transcriptional/translational feedback loops operated by a number of clock genes.
Mengna Li, Shujing Li, Luoying Zhang
doaj +1 more source
Nature Communications, 2022 Protein phosphorylation and dephosphorylation are essential aspects of biology. Wang et al., report that Toxoplasma gondiiprotein phosphatase 2A (PP2A) mediated dephosphorylation is critical for starch metabolism and bradyzoite differentiation.
Jin-Lei Wang +7 more
doaj +1 more source
A crosstalk between phosphorylation and ubiquitination of BNIP3 regulates mitophagy under hypoxia
Autophagy Reports, 2023 BNIP3 (BCL2/adenovirus e1B 19 kDa protein interacting protein 3) is a mitochondrial outer membrane protein that is sensitive to hypoxia and mediates mitophagy, a process important for mitochondrial quality control and to maintain energetic and redox ...
Yun-Ling He +4 more
doaj +1 more source