Results 51 to 60 of about 327,828 (303)

Protein phosphatase 2A holoenzymes regulate leucine-rich repeat kinase 2 phosphorylation and accumulation

Neurobiology of Disease, 2021
LRRK2 is a highly phosphorylated multidomain protein and mutations in the gene encoding LRRK2 are a major genetic determinant of Parkinson's disease (PD).
Matthieu Drouyer, Marc F. Bolliger, Evy Lobbestael, Chris Van den Haute, Marco Emanuele, Réginald Lefebvre, William Sibran, Tina De Wit, Coline Leghay, Eugénie Mutez, Nicolas Dzamko, Glenda M. Halliday, Shigeo Murayama, Alain Martoriati, Katia Cailliau, Jean-François Bodart, Marie-Christine Chartier-Harlin, Veerle Baekelandt, R. Jeremy Nichols, Jean-Marc Taymans   +19 more
doaj   +1 more source

Therapeutic relevance of the protein phosphatase 2A in cancer

Oncotarget, 2016
Chromosomal Instability (CIN) is regarded as a unifying feature of heterogeneous tumor populations, driving intratumoral heterogeneity. Polo-Like Kinase 1 (PLK1), a serine-threonine kinase that is often overexpressed across multiple tumor types, is one of the key regulators of CIN and is considered as a potential therapeutic target.
Cunningham, Chelsea E., Li, Shuangshuang, Vizeacoumar, Frederick S., Bhanumathy, Kalpana Kalyanasundaram, Lee, Joo Sang, Parameswaran, Sreejit, Furber, Levi, Abuhussein, Omar, Paul, James M., McDonald, Megan, Templeton, Shaina D., Shukla, Hersh, El Zawily, Amr M., Boyd, Frederick, Alli, Nezeka, Mousseau, Darrell D., Geyer, Ron, Bonham, Keith, Anderson, Deborah H., Yan, Jiong, Yu-Lee, Li-Yuan, Weaver, Beth A., Uppalapati, Maruti, Ruppin, Eytan, Sablina, Anna, Freywald, Andrew, Vizeacoumar, Franco J.   +26 more
openaire   +3 more sources

Microcystin-LR stabilizes c-myc protein by inhibiting protein phosphatase 2A in HEK293 cells

, 2014
Microcystin-LR is the most toxic and the most frequently encountered toxin produced by the cyanobacteria in the contaminated aquatic environment. Previous studies have demonstrated that Microcystin-LR is a potential carcinogen for animals and humans, and
Cai, Yan, Xie, P (reprint author), Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China., Zhao, Sujuan, Chen, Jun, Fan, Huihui, Ji, Wei, Xie, Ping, Xiao, Wuhan   +7 more
core   +1 more source

Protein Phosphatase 2A Mediates Oxidative Stress Induced Apoptosis in Osteoblasts

Mediators of Inflammation, 2015
Osteoporosis is one of the most common bone diseases, which is characterized by a systemic impairment of bone mass and fragility fractures. Age-related oxidative stress is highly associated with impaired osteoblastic dysfunctions and subsequent ...
Chong-xin Huang, Bo Lv, Yue Wang
doaj   +1 more source

Effects of Newly Synthesized DCP-LA-Phospholipids on Protein Kinase C and Protein Phosphatases

Cellular Physiology and Biochemistry, 2013
Background/Aims: The linoleic acid derivative DCP-LA selectively activates PKCε and inhibits protein phosphatase 1 (PP1). In the present study, we have newly synthesized phosphatidyl-ethanolamine, -serine, -choline, and -inositol containing DCP-LA at the
Takeshi Kanno, Ayako Tsuchiya, Tadashi Shimizu, Syuhei Nakao, Akito Tanaka, Tomoyuki Nishizaki   +5 more
doaj   +1 more source

Functional cdc25C dual-specificity phosphatase is required for S-phase entry in human cells

, 2003
In view of the common regulatory mechanism that induces transcription of tie mitotic phosphatase cdc25C and cyclin A at the beginning of S-phase, we investigated whether cdc25C was required for S-phase transit.
Patric Turowski, Franckhauser, Céline, Ned J. C. Lamb, Lamb, Ned,, Celine Franckhauser, Fernandez, A, Lamb, NJC, Turowski, P, Fernandez, Anne, Turowski, Patric, Morris, May, Franckhauser, C, Vaglio, P, Vaglio, Philippe, Morris, MC, Lamb, Ned, J., Anne Fernandez, May C. Morris, Anne Fern, Philippe Vaglio   +19 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase-1 in Tat-activated HIV-1 transcription

Retrovirology, 2005
Background HIV-1 Tat protein recruits human positive transcription elongation factor P-TEFb, consisting of CDK9 and cyclin T1, to HIV-1 transactivation response (TAR) RNA.
Brady John, Debebe Zufan, Washington Kareem, Ammosova Tatyana, Nekhai Sergei   +4 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein Phosphatase 2A (PP2A) Regulates EG5 to Control Mitotic Progression

Scientific Reports, 2017
EG5 (KIF11) is a member of the kinesin-like protein family involved in centrosome separation and bipolar spindle formation. When a cell enters mitosis, CDK1 phosphorylates EG5 at Thr926 and promotes EG5 localization on the mitotic spindle which drives ...
Yang Liu, Zhong Zhang, Hui Liang, Xuyang Zhao, Ling Liang, Guangxi Wang, Jingyi Yang, Yan Jin, Michael A. McNutt, Yuxin Yin   +9 more
doaj   +1 more source