Results 51 to 60 of about 4,194,516 (299)

A crosstalk between phosphorylation and ubiquitination of BNIP3 regulates mitophagy under hypoxia

Autophagy Reports, 2023
BNIP3 (BCL2/adenovirus e1B 19 kDa protein interacting protein 3) is a mitochondrial outer membrane protein that is sensitive to hypoxia and mediates mitophagy, a process important for mitochondrial quality control and to maintain energetic and redox ...
Yun-Ling He, Jian Li, Yan Cao, Hai-Tao Wu, Li-Ying Wu   +4 more
doaj   +1 more source

From Basic Science to Clinical Practice: The Role of Cancerous Inhibitor of Protein Phosphatase 2A (CIP2A)/p90 in Cancer

Frontiers in Genetics, 2023
Cancerous inhibitor of protein phosphatase 2A (CIP2A), initially reported as a tumor-associated antigen (known as p90), is highly expressed in most solid and hematological tumors. The interaction of CIP2A/p90, protein phosphatase 2A (PP2A), and c-Myc can
Beibei Chen, Beibei Chen, Huihui Hu, Huihui Hu, Xiaobing Chen, Xiaobing Chen   +5 more
doaj   +1 more source

Protein tyrosine phosphatase TbPTP1:A molecular switch controlling life cycle differentiation in trypanosomes [PDF]

, 2006
Differentiation in African trypanosomes (Trypanosoma brucei) entails passage between a mammalian host, where parasites exist as a proliferative slender form or a G0-arrested stumpy form, and the tsetse fly.
Szoor, Balazs; id_orcid, Matthews, Keith R., Helen McElhinney, Tabernero, Lydia, Wilson, Jude, Szöor, Balázs, Keith R. Matthews, Matthews, Keith R; id_orcid, Lydia Tabernero, Tabernero, Lydia; id_orcid, McElhinney, Helen, Balázs Szöőr, Jude Wilson   +12 more
core   +1 more source

The protein phosphatase 2A holoenzyme is a key regulator of starch metabolism and bradyzoite differentiation in Toxoplasma gondii

Nature Communications, 2022
Protein phosphorylation and dephosphorylation are essential aspects of biology. Wang et al., report that Toxoplasma gondiiprotein phosphatase 2A (PP2A) mediated dephosphorylation is critical for starch metabolism and bradyzoite differentiation.
Jin-Lei Wang, Ting-Ting Li, Hany M. Elsheikha, Qin-Li Liang, Zhi-Wei Zhang, Meng Wang, L. David Sibley, Xing-Quan Zhu   +7 more
doaj   +1 more source

Protein phosphatase 2A holoenzymes regulate leucine-rich repeat kinase 2 phosphorylation and accumulation

Neurobiology of Disease, 2021
LRRK2 is a highly phosphorylated multidomain protein and mutations in the gene encoding LRRK2 are a major genetic determinant of Parkinson's disease (PD).
Matthieu Drouyer, Marc F. Bolliger, Evy Lobbestael, Chris Van den Haute, Marco Emanuele, Réginald Lefebvre, William Sibran, Tina De Wit, Coline Leghay, Eugénie Mutez, Nicolas Dzamko, Glenda M. Halliday, Shigeo Murayama, Alain Martoriati, Katia Cailliau, Jean-François Bodart, Marie-Christine Chartier-Harlin, Veerle Baekelandt, R. Jeremy Nichols, Jean-Marc Taymans   +19 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Effects of Newly Synthesized DCP-LA-Phospholipids on Protein Kinase C and Protein Phosphatases

Cellular Physiology and Biochemistry, 2013
Background/Aims: The linoleic acid derivative DCP-LA selectively activates PKCε and inhibits protein phosphatase 1 (PP1). In the present study, we have newly synthesized phosphatidyl-ethanolamine, -serine, -choline, and -inositol containing DCP-LA at the
Takeshi Kanno, Ayako Tsuchiya, Tadashi Shimizu, Syuhei Nakao, Akito Tanaka, Tomoyuki Nishizaki   +5 more
doaj   +1 more source

Ceramide activates heterotrimeric protein phosphatase 2A

Journal of Biological Chemistry, 1993
Ceramide activates a cytosolic protein phosphatase present in rat T9 glioma cells and rat brain. Ceramide-activated protein phosphatase (CAPP) was found to share several properties with protein phosphatase 2A (PP2A) leading to the hypothesis that ceramide may directly activate PP2A.
R T, Dobrowsky, C, Kamibayashi, M C, Mumby, Y A, Hannun   +3 more
openaire   +2 more sources

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Microcystin-LR stabilizes c-myc protein by inhibiting protein phosphatase 2A in HEK293 cells

, 2014
Microcystin-LR is the most toxic and the most frequently encountered toxin produced by the cyanobacteria in the contaminated aquatic environment. Previous studies have demonstrated that Microcystin-LR is a potential carcinogen for animals and humans, and
Cai, Yan, Xie, P (reprint author), Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China., Zhao, Sujuan, Chen, Jun, Fan, Huihui, Ji, Wei, Xie, Ping, Xiao, Wuhan   +7 more
core   +1 more source