Results 61 to 70 of about 4,194,516 (299)

Protein Phosphatase 2A Mediates Oxidative Stress Induced Apoptosis in Osteoblasts

Mediators of Inflammation, 2015
Osteoporosis is one of the most common bone diseases, which is characterized by a systemic impairment of bone mass and fragility fractures. Age-related oxidative stress is highly associated with impaired osteoblastic dysfunctions and subsequent ...
Chong-xin Huang, Bo Lv, Yue Wang
doaj   +1 more source

Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase-1 in Tat-activated HIV-1 transcription

Retrovirology, 2005
Background HIV-1 Tat protein recruits human positive transcription elongation factor P-TEFb, consisting of CDK9 and cyclin T1, to HIV-1 transactivation response (TAR) RNA.
Brady John, Debebe Zufan, Washington Kareem, Ammosova Tatyana, Nekhai Sergei   +4 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

The effects of protein phosphatase inhibitors on the duration of central sensitization of rat dorsal horn neurons following injection of capsaicin

Molecular Pain, 2006
Protein kinases and phosphatases catalyze opposing reactions of phosphorylation and dephosphorylation, which may modulate the function of crucial signaling proteins in central nervous system.
Fang Li, Wu Jing, Zhang Xuan, Willis William D   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Role of Plastid Protein Phosphatase TAP38 in LHCII Dephosphorylation and Thylakoid Electron Flow [PDF]

, 2010
Short-term changes in illumination elicit alterations in thylakoid protein phosphorylation and reorganization of the photosynthetic machinery. Phosphorylation of LHCII, the light-harvesting complex of photosystem II, facilitates its relocation to ...
Leister D., Pesaresi, Paolo, Alexander Hertle, Mathias Pribil, M. Pribil, Leister Dario, Barbato, Roberto, P. Pesaresi, Hertle, Alexander, Leister, Dario, Pesaresi Paolo, R. Barbato, Hertle Alexander, Barbato Roberto, Er Hertle, D. Leister, Pribil M, Roberto Barbato, Dario Leister, Paolo Pesaresi, A. Hertle, Pesaresi P, Pribil, Mathias, Hertle A, Pribil Mathias   +24 more
core   +2 more sources

Protein Phosphatase 2A (PP2A) Regulates EG5 to Control Mitotic Progression

Scientific Reports, 2017
EG5 (KIF11) is a member of the kinesin-like protein family involved in centrosome separation and bipolar spindle formation. When a cell enters mitosis, CDK1 phosphorylates EG5 at Thr926 and promotes EG5 localization on the mitotic spindle which drives ...
Yang Liu, Zhong Zhang, Hui Liang, Xuyang Zhao, Ling Liang, Guangxi Wang, Jingyi Yang, Yan Jin, Michael A. McNutt, Yuxin Yin   +9 more
doaj   +1 more source

Protein Phosphatase 2A in Lipopolysaccharide-Induced Cyclooxygenase-2 Expression in Murine Lymphatic Endothelial Cells. [PDF]

PLoS ONE, 2015
The lymphatic endothelium plays an important role in the maintenance of tissue fluid homeostasis. It also participates in the pathogenesis of several inflammatory diseases.
Yu-Fan Chuang, Mei-Chieh Chen, Shiu-Wen Huang, Ya-Fen Hsu, George Ou, Yu-Jou Tsai, Ming-Jen Hsu   +6 more
doaj   +1 more source

Therapeutic relevance of the protein phosphatase 2A in cancer

Oncotarget, 2016
Chromosomal Instability (CIN) is regarded as a unifying feature of heterogeneous tumor populations, driving intratumoral heterogeneity. Polo-Like Kinase 1 (PLK1), a serine-threonine kinase that is often overexpressed across multiple tumor types, is one of the key regulators of CIN and is considered as a potential therapeutic target.
Cunningham, Chelsea E., Li, Shuangshuang, Vizeacoumar, Frederick S., Bhanumathy, Kalpana Kalyanasundaram, Lee, Joo Sang, Parameswaran, Sreejit, Furber, Levi, Abuhussein, Omar, Paul, James M., McDonald, Megan, Templeton, Shaina D., Shukla, Hersh, El Zawily, Amr M., Boyd, Frederick, Alli, Nezeka, Mousseau, Darrell D., Geyer, Ron, Bonham, Keith, Anderson, Deborah H., Yan, Jiong, Yu-Lee, Li-Yuan, Weaver, Beth A., Uppalapati, Maruti, Ruppin, Eytan, Sablina, Anna, Freywald, Andrew, Vizeacoumar, Franco J.   +26 more
openaire   +3 more sources

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source