Results 31 to 40 of about 324,787 (261)
Free Fatty Acids Inhibit Protein Tyrosine Phosphatase 1B and Activate Akt
Cellular Physiology and Biochemistry, 2013 Background/Aims: Accumulating evidence has suggested that free fatty acids (FFAs) interact with protein kinases and protein phosphatases. The present study examined the effect of FFAs on protein phosphatases and Akt.
Eisuke Shibata +6 more
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Autoregulation of Protein Phosphatase Type 2A Expression [PDF]
Journal of Biological Chemistry, 1998 Protein phosphatases are involved in many cellular processes. One of the most abundant of these enzymes, the serine/threonine-specific protein phosphatase type 2A (PP2A), is present in most eukaryotic cells and serves a variety of functions. However, the detailed study of its regulation and function has been hampered by the difficulty of manipulating ...
Z, Baharians, A H, Schönthal
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Generation of active protein phosphatase 2A is coupled to holoenzyme assembly. [PDF]
PLoS Biology, 2007 Protein phosphatase 2A (PP2A) is a prime example of the multisubunit architecture of protein serine/threonine phosphatases. Until substrate-specific PP2A holoenzymes assemble, a constitutively active, but nonspecific, catalytic C subunit would constitute
Hans Hombauer +6 more
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Phosphorylation Promotes the Accumulation of PERIOD Protein Foci
Research, 2023 Circadian clock drives the 24-h rhythm in our behavior and physiology. The molecular clock consists of a series of transcriptional/translational feedback loops operated by a number of clock genes.
Mengna Li, Shujing Li, Luoying Zhang
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Defects of protein phosphatase 2A causes corticosteroid insensitivity in severe asthma. [PDF]
PLoS ONE, 2011 BACKGROUND: Corticosteroid insensitivity is a major barrier of treatment for some chronic inflammatory diseases, such as severe asthma, but the molecular mechanism of the insensitivity has not been fully elucidated.
Yoshiki Kobayashi +3 more
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Frontiers in Genetics, 2023 Cancerous inhibitor of protein phosphatase 2A (CIP2A), initially reported as a tumor-associated antigen (known as p90), is highly expressed in most solid and hematological tumors. The interaction of CIP2A/p90, protein phosphatase 2A (PP2A), and c-Myc can
Beibei Chen +5 more
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A crosstalk between phosphorylation and ubiquitination of BNIP3 regulates mitophagy under hypoxia
Autophagy Reports, 2023 BNIP3 (BCL2/adenovirus e1B 19 kDa protein interacting protein 3) is a mitochondrial outer membrane protein that is sensitive to hypoxia and mediates mitophagy, a process important for mitochondrial quality control and to maintain energetic and redox ...
Yun-Ling He +4 more
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Therapeutic reactivation of protein phosphatase 2A in acute myeloid leukemia
Frontiers in Oncology, 2015 Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase that is required for normal cell growth and development. PP2A is a potent tumor suppressor, which is inactivated in cancer cells as a result of genetic deletions and mutations.
Kavitha eRamaswamy +2 more
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Nature Communications, 2022 Protein phosphorylation and dephosphorylation are essential aspects of biology. Wang et al., report that Toxoplasma gondiiprotein phosphatase 2A (PP2A) mediated dephosphorylation is critical for starch metabolism and bradyzoite differentiation.
Jin-Lei Wang +7 more
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Neurobiology of Disease, 2021 LRRK2 is a highly phosphorylated multidomain protein and mutations in the gene encoding LRRK2 are a major genetic determinant of Parkinson's disease (PD).
Matthieu Drouyer +19 more
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