Results 31 to 40 of about 327,828 (303)

Cancerous inhibitor of protein phosphatase 2A (CIP2A) modifies energy metabolism via 50 AMP-activated protein kinase signalling in malignant cells [PDF]

, 2019
Cancerous inhibitor of protein phosphatase 2A (CIP2A) is an adverse biomarker across many malignancies. Using K562 cells engineered to have high or low CIP2A expression, we show that high CIP2A levels significantly bias cellular energy production towards
Austin, GM, Clark, Richard E., Dunn, K, Scott, Laura, Lucas, Claire, Glenn, MA, Austin, James A., Austin, JA, Scott, L, Glenn, Mark A., Dunn, Karen, Lucas, CM, Jenkins, Rosalind E., Jenkins, RE, Austin, Gemma M., Clark, RE   +15 more
core   +1 more source

Isolation and partial characterization of a protein with HMG-CoA reductase phosphatase activity associated with rat liver microsomal membranes.

Journal of Lipid Research, 1991
Several rat liver HMG-CoA-reductase (HMG-CoA-Rd) phosphatase activities have been shown to be associated with the endoplasmic reticulum. These activities were not due to glycogen contamination, as judged not only from different patterns of solubilization
G Asins, D Serra, FG Hegardt
doaj   +1 more source

Mechanisms of the scaffold subunit in facilitating protein phosphatase 2A methylation. [PDF]

PLoS ONE, 2014
The function of the biologically essential protein phosphatase 2A (PP2A) relies on formation of diverse heterotrimeric holoenzymes, which involves stable association between PP2A scaffold (A) and catalytic (C or PP2Ac) subunits and binding of variable ...
Vitali Stanevich, Aiping Zheng, Feng Guo, Li Jiang, Nathan Wlodarchak, Yongna Xing   +5 more
doaj   +1 more source

Protein phosphatase 2A in Alzheimer's disease

Pathophysiology, 2009
Protein phosphatase 2A (PP2A) is the predominant serine/threonine phosphatase in eukaryotic cells. In Alzheimer's disease (AD), PP2A activity is decreased. Decreased PP2A activity is suggested to be involved in NFT formation and neurodegeneration. PP2A is also involved in APP secreting pathway, thus probably participating the Abeta production. Based on
Rong, Liu, Jian-Zhi, Wang
openaire   +2 more sources

The rim15-Endosulfine-PP2ACdc55 signalling module regulates entry into gametogenesis and quiescence via distinct mechanisms in budding yeast [PDF]

, 2013
Quiescence and gametogenesis represent two distinct survival strategies in response to nutrient starvation in budding yeast. Precisely how environmental signals are sensed by yeast cells to trigger quiescence and gametogenesis is not fully understood.
Sourav Sarkar, Dalgaard Jacob Z., Prakash Arumugam, Arumugam P., Sarkar, Sourav, Jonathan B. A. Millar, Sarkar S., Arumugam Prakash, Millar, Jonathan B. A., Jacob Z. Dalgaard (303312), Jacob Z. Dalgaard, Arumugam, Prakash, Sourav Sarkar (430861), Millar Jonathan B. A., Jonathan B. A. Millar (430863), Sarkar Sourav, Millar J.B.A., Jonathan B A Millar, Dalgaard, Jacob Z., Jacob Z Dalgaard, Dalgaard J.Z., Prakash Arumugam (303310)   +21 more
core   +1 more source

Marine Longilenes, Oxasqualenoids with Ser-Thr Protein Phosphatase 2A Inhibition Activity

Marine Drugs, 2018
The red seaweed Laurencia viridis is a rich source of oxygenated secondary metabolites that were derived from squalene. We report here the structures of three novel compounds, (+)-longilene peroxide (1), longilene (2), and (+)-prelongilene (3) that were ...
Francisco Cen-Pacheco, Claudia Pérez Manríquez, María Luisa Souto, Manuel Norte, José Javier Fernández, Antonio Hernández Daranas   +5 more
doaj   +1 more source

A stable association with PME‐1 may be dispensable for PP2A demethylation – implications for the detection of PP2A methylation and immunoprecipitation

FEBS Open Bio, 2018
Reversible methyl‐esterification (methylation) of Leu309 in the protein phosphatase 2A catalytic subunit (PP2Ac) is essential for proper biogenesis of the PP2A holoenzyme.
Ryotaro Yabe, Shunya Tsuji, Satoru Mochida, Tsuyoshi Ikehara, Tatsuya Usui, Takashi Ohama, Koichi Sato   +6 more
doaj   +1 more source

Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A

Neurobiology of Disease, 2008
The down-regulation of protein phosphatase 2A (PP2A) activity is thought to play an important role in the formation of tau hyperphosphorylation in the Alzheimer's disease (AD) brain. Methylation of the PP2A catalytic subunit at the L309 site can potently
Xin-Wen Zhou, Jan-Åke Gustafsson, Heikki Tanila, Cecilia Bjorkdahl, Rong Liu, Bengt Winblad, Jin-Jing Pei   +6 more
doaj   +1 more source

Protein phosphatase 2A: a target for anticancer therapy [PDF]

The Lancet Oncology, 2013
Protein phosphatase 2A (PP2A), one of the main serine-threonine phosphatases in mammalian cells, maintains cell homoeostasis by counteracting most of the kinase-driven intracellular signalling pathways. Unrestrained activation of oncogenic kinases together with inhibition of tumour suppressors is often required for development of cancer.
Danilo, Perrotti, Paolo, Neviani
openaire   +2 more sources

Autoregulation of Protein Phosphatase Type 2A Expression [PDF]

Journal of Biological Chemistry, 1998
Protein phosphatases are involved in many cellular processes. One of the most abundant of these enzymes, the serine/threonine-specific protein phosphatase type 2A (PP2A), is present in most eukaryotic cells and serves a variety of functions. However, the detailed study of its regulation and function has been hampered by the difficulty of manipulating ...
Z, Baharians, A H, Schönthal
openaire   +2 more sources