Results 1 to 10 of about 887,918 (307)

Protein kinase A (PKA) phosphorylation of Shp2 inhibits its phosphatase activity and modulates ligand specificity. [PDF]

, 2015
Pathological cardiac hypertrophy (an increase in cardiac mass resulting from stress-induced cardiac myocyte growth) is a major factor underlying heart failure.
Burmeister, BT, Carnegie, GK, Gold, MG, O'Bryan, JP, Skidgel, RA, Wang, L   +5 more
core   +1 more source

Rhizobiales-like Phosphatase 2 from Arabidopsis thaliana Is a Novel Phospho-tyrosine-specific Phospho-protein Phosphatase (PPP) Family Protein Phosphatase [PDF]

Journal of Biological Chemistry, 2016
Cellular signaling through protein tyrosine phosphorylation is well established in mammalian cells. Although lacking the classic tyrosine kinases present in humans, plants have a tyrosine phospho-proteome that rivals human cells. Here we report a novel plant tyrosine phosphatase from Arabidopsis thaliana (AtRLPH2) that, surprisingly, has the sequence ...
R Glen, Uhrig, Anne-Marie, Labandera, Jamshed, Muhammad, Marcus, Samuel, Greg B, Moorhead   +4 more
openaire   +2 more sources

Type One Protein Phosphatase 1 and Its Regulatory Protein Inhibitor 2 Negatively Regulate ABA Signaling.

PLoS Genetics, 2016
The phytohormone abscisic acid (ABA) regulates plant growth, development and responses to biotic and abiotic stresses. The core ABA signaling pathway consists of three major components: ABA receptor (PYR1/PYLs), type 2C Protein Phosphatase (PP2C) and ...
Yueh-Ju Hou, Yingfang Zhu, Pengcheng Wang, Yang Zhao, Shaojun Xie, Giorgia Batelli, Bangshing Wang, Cheng-Guo Duan, Xingang Wang, Lu Xing, Mingguang Lei, Jun Yan, Xiaohong Zhu, Jian-Kang Zhu   +13 more
doaj   +1 more source

SH2 domain‐containing protein tyrosine phosphatase‐2 is enriched in eyelid specimens of rosacea

Skin Health and Disease, 2023
Background Rosacea is a cutaneous disease that may secondarily affect the ocular surface. Due to the vision threatening, cosmetic, psychological, and work productivity impact, the identification of cellular targets that govern rosacea would enhance our ...
Apoorv Chebolu, Ramon Bossardi Ramos, Thilaka Arunachalam, Alejandro Pablo Adam, Edward J. Wladis   +4 more
doaj   +1 more source

Polyphyllin D Shows Anticancer Effect through a Selective Inhibition of Src Homology Region 2-Containing Protein Tyrosine Phosphatase-2 (SHP2)

Molecules, 2021
Natural products have continued to offer tremendous opportunities for drug development, as they have long been used in traditional medicinal systems. SHP2 has served as an anticancer target.
Se Jeong Kwon, Dohee Ahn, Hyun-Mo Yang, Hyo Jin Kang, Sang J. Chung   +4 more
doaj   +1 more source

A new monoclonal antibody detects downregulation of protein tyrosine phosphatase receptor type γ in chronic myeloid leukemia patients [PDF]

, 2017
Background: Protein tyrosine phosphatase receptor gamma (PTPRG) is a ubiquitously expressed member of the protein tyrosine phosphatase family known to act as a tumor suppressor gene in many different neoplasms with mechanisms of inactivation including ...
Al Sayab, Ali, Al-Dewik, Nader, Fiorini, Zeno, Holyoake, Tessa L., Ismail, Mohamed A., Krampera, Mauro, Lorenzetto, Erika, Mafficini, Andrea, Monne, Maria, Moratti, Elisabetta, Pellicano, Francesca, Sorio, Claudio, Tecchio, Cristina, Tomasello, Luisa, Vezzalini, Marzia, Yassin, Mohamed   +15 more
core   +3 more sources

The protein tyrosine phosphatase Shp-2 regulates RhoA activity [PDF]

Current Biology, 2000
Remodeling of filamentous actin into distinct arrangements is precisely controlled by members of the Rho family of small GTPases [1]. A well characterized member of this family is RhoA, whose activation results in reorganization of the cytoskeleton into thick actin stress fibers terminating in integrin-rich focal adhesions [2].
Schoenwaelder, Simone M., Petch, Leslie A., Williamson, David, Shen, Randy, Feng, Gen-Sheng, Burridge, Keith   +5 more
openaire   +2 more sources

T cell-specific constitutive active SHP2 enhances T cell memory formation and reduces T cell activation

Frontiers in Immunology, 2022
Upon antigen recognition by the T cell receptor (TCR), a complex signaling network orchestrated by protein-tyrosine kinases (PTKs) and protein-tyrosine phosphatases (PTPs) regulates the transmission of the extracellular signal to the nucleus. The role of
Clemens Cammann, Clemens Cammann, Nicole Israel, Nicole Israel, Sarah Frentzel, Sarah Frentzel, Andreas Jeron, Andreas Jeron, Eylin Topfstedt, Thomas Schüler, Luca Simeoni, Martin Zenker, Hans Joerg Fehling, Burkhart Schraven, Dunja Bruder, Dunja Bruder, Ulrike Seifert, Ulrike Seifert   +17 more
doaj   +1 more source

Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. [PDF]

, 2017
Obesity-associated insulin resistance plays a central role in type 2 diabetes. As such, tyrosine phosphatases that dephosphorylate the insulin receptor (IR) are potential therapeutic targets.
Aleshin, Alexander E, Ardecky, Robert J, Bankston, Laurie A, Barquilla, Antonio, Bliss, Matthew R, Bobkov, Andrey A, Bottini, Nunzio, Cadwell, Gregory W, Chung, Thomas DY, Ganji, Santhi R, Hedrick, Michael P, Khare, Shilpi, Kiselar, Janna, Liddington, Robert C, Liu, Yingge, Mustelin, Tomas, Pinkerton, Anthony B, Schenk, Simon, Stanford, Stephanie M, Yamamoto, Fusayo, Yu, Jinghua, Zhang, Vida, Zou, Jiwen   +22 more
core   +2 more sources

Modeling (not so) rare developmental disorders associated with mutations in the protein-tyrosine phosphatase SHP2

Frontiers in Cell and Developmental Biology, 2022
Src homology region 2 (SH2)-containing protein tyrosine phosphatase 2 (SHP2) is a highly conserved protein tyrosine phosphatase (PTP), which is encoded by PTPN11 and is indispensable during embryonic development.
Maja Solman, Daniëlle T. J. Woutersen, Jeroen den Hertog, Jeroen den Hertog   +3 more
doaj   +1 more source