Results 31 to 40 of about 625,556 (313)

Protein Phosphatase-1 Inhibitor-2 Is a Novel Memory Suppressor [PDF]

The Journal of Neuroscience, 2015
Reversible phosphorylation, a fundamental regulatory mechanism required for many biological processes including memory formation, is coordinated by the opposing actions of protein kinases and phosphatases. Type I protein phosphatase (PP1), in particular, has been shown to constrain learning and memory formation.
Hongtian, Yang, Hailong, Hou, Amanda, Pahng, Hua, Gu, Angus C, Nairn, Ya-Ping, Tang, Paul J, Colombo, Houhui, Xia   +7 more
openaire   +2 more sources

Structural Basis for Regulation of Protein Phosphatase 1 by Inhibitor-2 [PDF]

Journal of Biological Chemistry, 2007
The functional specificity of type 1 protein phosphatases (PP1) depends on the associated regulatory/targeting and inhibitory subunits. To gain insights into the mechanism of PP1 regulation by inhibitor-2, an ancient and intrinsically disordered regulator, we solved the crystal structure of the complex to 2.5A resolution.
Thomas D, Hurley, Jie, Yang, Lili, Zhang, Kristie D, Goodwin, Qin, Zou, Marc, Cortese, A Keith, Dunker, Anna A, DePaoli-Roach   +7 more
openaire   +2 more sources

Isolation and partial characterization of a protein with HMG-CoA reductase phosphatase activity associated with rat liver microsomal membranes.

Journal of Lipid Research, 1991
Several rat liver HMG-CoA-reductase (HMG-CoA-Rd) phosphatase activities have been shown to be associated with the endoplasmic reticulum. These activities were not due to glycogen contamination, as judged not only from different patterns of solubilization
G Asins, D Serra, FG Hegardt
doaj   +1 more source

Inhibition of the tyrosine phosphatase SHP-2 suppresses angiogenesis in vitro and in vivo [PDF]

, 2007
Endothelial cell survival is indispensable to maintain endothelial integrity and initiate new vessel formation. We investigated the role of SHP-2 in endothelial cell survival and angiogenesis in vitro as well as in vivo.
Groesser, Leopold, Walzog, Barbara, Gloe, Torsten, Sohn, Hae-Young, Krötz, Florian, Plank, Christian, Pohl, Ulrich, Hellwig, Nicole, Mannell, Hanna   +8 more
core   +1 more source

A unique kelch domain phosphatase in plasmodium regulates ookinete morphology, motility and invasion [PDF]

, 2012
Signalling through post-translational modification (PTM) of proteins is a process central to cell homeostasis, development and responses to external stimuli.
Heli J. Vaikkinen (137832), Nisha Philip (137829), Laurence Tetley, Tetley, L., Waters, A.P., Vaikkinen, Heli J, Tetley, Laurence, Waters, Andrew P., Nisha Philip, Vaikkinen, H.J., Andrew P. Waters (15293), Laurence Tetley (37791), Heli J Vaikkinen, Philip, N., Philip, Nisha, Andrew P Waters   +15 more
core   +1 more source

Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Promotes Inflammation and Accelerates Osteoarthritis by Activating β-Catenin

Frontiers in Cell and Developmental Biology, 2021
Osteoarthritis (OA) is a chronic articular disease characterized by cartilage degradation, subchondral bone remodeling and osteophyte formation. Src homology 2 domain-containing protein tyrosine phosphatase (SHP2) has not been fully investigated in the ...
Tenghui Tao, Danni Luo, Chenghao Gao, Hui Liu, Zehua Lei, Wenbin Liu, Chuankun Zhou, Dahu Qi, Zhenhan Deng, Xuying Sun, Jun Xiao   +10 more
doaj   +1 more source

Rhizobiales-like Phosphatase 2 from Arabidopsis thaliana Is a Novel Phospho-tyrosine-specific Phospho-protein Phosphatase (PPP) Family Protein Phosphatase [PDF]

Journal of Biological Chemistry, 2016
Cellular signaling through protein tyrosine phosphorylation is well established in mammalian cells. Although lacking the classic tyrosine kinases present in humans, plants have a tyrosine phospho-proteome that rivals human cells. Here we report a novel plant tyrosine phosphatase from Arabidopsis thaliana (AtRLPH2) that, surprisingly, has the sequence ...
Uhrig, R, Labandera, Anne-Marie, Muhammad, Jamshed, Samuel, Marcus, Moorhead, Greg   +4 more
openaire   +3 more sources

Dexamethasone-Induced Expression of Endothelial Mitogen-Activated Protein Kinase Phosphatase-1 Involves Activation of the Transcription Factors Activator Protein-1 and 3',5'-Cyclic Adenosine 5'-Monophosphate Response Element-Binding Protein and the Generation of Reactive Oxygen Species [PDF]

, 2008
We have recently identified the MAPK phosphatase (MKP)-1 as a novel mediator of the antiinflammatory properties of glucocorticoids (dexamethasone) in the human endothelium. However, nothing is as yet known about the signaling pathways responsible for the
Vollmar, Angelika M., Zahler, Stefan, Fürst, Robert   +2 more
core   +1 more source

Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase

Marine Drugs, 2006
: Manzamenones A~C (1~3) and E~F (5~6), unique oxylipin metabolites isolated from a marine sponge Plakortis sp., have been found to exhibit inhibitory activity against Tcell protein tyrosine phosphatase (TCPTP). The inhibitory activity of 2 and 5 against
Jun'ichi Kobayashi, Kunimi Kikuchi, Naohito Aoki, Shinya Mitsuhashi, Tadashi Okada, Hiroshi Shima, Takaaki Kubota, Yusuke Wakuda   +7 more
doaj   +1 more source

Protein phosphatase 1α is a Ras-activated Bad phosphatase that regulates interleukin-2 deprivation-induced apoptosis [PDF]

The EMBO Journal, 2000
Growth factor deprivation is a physiological mechanism to regulate cell death. We utilize an interleukin-2 (IL-2)-dependent murine T-cell line to identify proteins that interact with Bad upon IL-2 stimulation or deprivation. Using the yeast two-hybrid system, glutathione S-transferase (GST) fusion proteins and co-immunoprecipitation techniques, we ...
Ayllon, V., Martinez, C., Garcia, Alphonse, Cayla, Xavier, Rebollo, A.   +4 more
openaire   +4 more sources