Results 31 to 40 of about 2,399,730 (304)

Isolation and partial characterization of a protein with HMG-CoA reductase phosphatase activity associated with rat liver microsomal membranes.

Journal of Lipid Research, 1991
Several rat liver HMG-CoA-reductase (HMG-CoA-Rd) phosphatase activities have been shown to be associated with the endoplasmic reticulum. These activities were not due to glycogen contamination, as judged not only from different patterns of solubilization
G Asins, D Serra, FG Hegardt
doaj   +1 more source

Mitogen-activated protein kinase phosphatase 2 regulates histone H3 phosphorylation via interaction with vaccinia-related kinase 1

Molecular Biology of the Cell, 2013
Vaccinia-related kinase 1 (VRK1) is a histone kinase that phosphorylates histone H3 at Thr-3 and Ser-10. This study shows that mitogen-activated protein kinase phosphatase 2 regulates this phosphorylation negatively via interaction with VRK1, regardless ...
Min-Woo Jeong, Tae-Hong Kang, Wanil Kim, Yoon Ha Choi, Kyong-Tai Kim   +4 more
semanticscholar   +1 more source

Protein Phosphatase-1 Inhibitor-2 Is a Novel Memory Suppressor [PDF]

The Journal of Neuroscience, 2015
Reversible phosphorylation, a fundamental regulatory mechanism required for many biological processes including memory formation, is coordinated by the opposing actions of protein kinases and phosphatases. Type I protein phosphatase (PP1), in particular, has been shown to constrain learning and memory formation.
Hongtian, Yang, Hailong, Hou, Amanda, Pahng, Hua, Gu, Angus C, Nairn, Ya-Ping, Tang, Paul J, Colombo, Houhui, Xia   +7 more
openaire   +2 more sources

A salicylic acid-based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2)

Journal of Medicinal Chemistry, 2010
The Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) plays a pivotal role in growth factor and cytokine signaling. Gain-of-function SHP2 mutations are associated with Noonan syndrome, various kinds of leukemias and solid tumors ...
Xian Zhang, Yantao He, Sijiu Liu, Zhihong Yu, Zhong-Xing Jiang, Zhenyun Yang, Yuanshu Dong, S. Nabinger, Li Wu, A. Gunawan, Lina Wang, R. Chan, Zhon-Yin Zhang   +12 more
semanticscholar   +1 more source

Structural Basis for Regulation of Protein Phosphatase 1 by Inhibitor-2 [PDF]

Journal of Biological Chemistry, 2007
The functional specificity of type 1 protein phosphatases (PP1) depends on the associated regulatory/targeting and inhibitory subunits. To gain insights into the mechanism of PP1 regulation by inhibitor-2, an ancient and intrinsically disordered regulator, we solved the crystal structure of the complex to 2.5A resolution.
Thomas D, Hurley, Jie, Yang, Lili, Zhang, Kristie D, Goodwin, Qin, Zou, Marc, Cortese, A Keith, Dunker, Anna A, DePaoli-Roach   +7 more
openaire   +2 more sources

Src Homology 2 Protein Tyrosine Phosphatase (SHPTP2)/Src Homology 2 Phosphatase 2 (SHP2) Tyrosine Phosphatase Is a Positive Regulator of the Interleukin 5 Receptor Signal Transduction Pathways Leading to the Prolongation of Eosinophil Survival

Journal of Experimental Medicine, 1997
Interleukin-5 (IL-5) regulates the growth and function of eosinophils. It induces rapid tyrosine phosphorylation of Lyn and Jak2 tyrosine kinases. The role of tyrosine phosphatases in IL-5 signal transduction has not been investigated.
K. Pazdrak, T. Adachi, R. Alam
semanticscholar   +1 more source

Rhizobiales-like Phosphatase 2 from Arabidopsis thaliana Is a Novel Phospho-tyrosine-specific Phospho-protein Phosphatase (PPP) Family Protein Phosphatase [PDF]

Journal of Biological Chemistry, 2016
Cellular signaling through protein tyrosine phosphorylation is well established in mammalian cells. Although lacking the classic tyrosine kinases present in humans, plants have a tyrosine phospho-proteome that rivals human cells. Here we report a novel plant tyrosine phosphatase from Arabidopsis thaliana (AtRLPH2) that, surprisingly, has the sequence ...
Uhrig, R, Labandera, Anne-Marie, Muhammad, Jamshed, Samuel, Marcus, Moorhead, Greg   +4 more
openaire   +3 more sources

Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase

Marine Drugs, 2006
: Manzamenones A~C (1~3) and E~F (5~6), unique oxylipin metabolites isolated from a marine sponge Plakortis sp., have been found to exhibit inhibitory activity against Tcell protein tyrosine phosphatase (TCPTP). The inhibitory activity of 2 and 5 against
Jun'ichi Kobayashi, Kunimi Kikuchi, Naohito Aoki, Shinya Mitsuhashi, Tadashi Okada, Hiroshi Shima, Takaaki Kubota, Yusuke Wakuda   +7 more
doaj   +1 more source

Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Promotes Inflammation and Accelerates Osteoarthritis by Activating β-Catenin

Frontiers in Cell and Developmental Biology, 2021
Osteoarthritis (OA) is a chronic articular disease characterized by cartilage degradation, subchondral bone remodeling and osteophyte formation. Src homology 2 domain-containing protein tyrosine phosphatase (SHP2) has not been fully investigated in the ...
Tenghui Tao, Danni Luo, Chenghao Gao, Hui Liu, Zehua Lei, Wenbin Liu, Chuankun Zhou, Dahu Qi, Zhenhan Deng, Xuying Sun, Jun Xiao   +10 more
doaj   +1 more source

Phosphotyrosyl-protein phosphatase of TCRC-2 cells.

Journal of Biological Chemistry, 1982
Homogenization of TCRC-2 cells yielded a phosphotyrosyl-protein phosphatase with a specific activity approximately 10-=fold higher in particulate than in soluble fractions. Over 90% of the phosphotyrosyl-protein phosphatase associated with the particles was solubilized with 1.0% Nonidet P-40.
G, Swarup, K V, Speeg, S, Cohen, D L, Garbers   +3 more
openaire   +2 more sources