Results 51 to 60 of about 2,399,730 (304)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Toxins of Okadaic Acid-Group Increase Malignant Properties in Cells of Colon Cancer

Toxins, 2020
Diarrhetic shellfish poisoning (DSP) is a syndrome caused by the intake of shellfish contaminated with a group of lipophilic and thermostable toxins, which consists of okadaic acid (OA), dinophysistoxin-1 (DTX-1) and dinophysistoxin-2 (DTX-2).
Danae Jiménez-Cárcamo, Carlos García, Héctor R. Contreras   +2 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

HPN, a Synthetic Analogue of Bromophenol from Red Alga Rhodomela confervoides: Synthesis and Anti-Diabetic Effects in C57BL/KsJ-db/db Mice

Marine Drugs, 2013
3,4-Dibromo-5-(2-bromo-3,4-dihydroxy-6-(isopropoxymethyl)benzyl)benzene-1,2-diol (HPN) is a synthetic analogue of 3,4-dibromo-5-(2-bromo-3,4-dihydroxy-6-(ethoxymethyl)benzyl)benzene-1,2-diol (BPN), which is isolated from marine red alga Rhodomela ...
Jingya Li, Tao Wang, Luyong Zhang, Chao Guo, Bo Jiang, Shuju Guo, Dayong Shi   +6 more
doaj   +1 more source

Hepatitis C Virus Core Protein Down-Regulates Expression of Src-Homology 2 Domain Containing Protein Tyrosine Phosphatase by Modulating Promoter DNA Methylation

Viruses, 2021
Hepatitis C virus (HCV) is the major causative pathogen associated with liver cirrhosis and hepatocellular carcinoma. The main virion component, the core (C) protein, has been implicated in several aspects of HCV pathology including oncogenesis and ...
Priya Devi, Seisuke Ota, Tanel Punga, Anders Bergqvist   +3 more
doaj   +1 more source

Activation of Mitochondrial Protein Phosphatase SLP2 by MIA40 Regulates Seed Germination1[OPEN]

Plant Physiology, 2016
The serine/threonine protein phosphatase SLP2 is mitochondrial intermembrane space localized and redox activated by the oxidoreductase Mia40. Reversible protein phosphorylation catalyzed by protein kinases and phosphatases represents the most prolific ...
Glen R. Uhrig, A. Labandera, L. Tang, Nicholas A Sieben, Marilyn Goudreault, E. Yeung, A. Gingras, M. Samuel, G. Moorhead   +8 more
semanticscholar   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

T Cell Protein Tyrosine Phosphatase in Osteoimmunology

Frontiers in Immunology, 2021
Osteoimmunology highlights the two-way communication between bone and immune cells. T cell protein tyrosine phosphatase (TCPTP), also known as protein-tyrosine phosphatase non-receptor 2 (PTPN2), is an intracellular protein tyrosine phosphatase (PTP ...
Ya-nan Wang, Ya-nan Wang, Ya-nan Wang, Shiyue Liu, Shiyue Liu, Shiyue Liu, Tingting Jia, Tingting Jia, Tingting Jia, Yao Feng, Yao Feng, Yao Feng, Wenjing Zhang, Wenjing Zhang, Wenjing Zhang, Xin Xu, Xin Xu, Xin Xu, Dongjiao Zhang, Dongjiao Zhang, Dongjiao Zhang   +20 more
doaj   +1 more source

Activation of protein phosphatase 2A tumor suppressor as potential treatment of pancreatic cancer

Molecular Oncology, 2015
We utilized three tiers of screening to identify novel therapeutic agents for pancreatic cancers. First, we analyzed 14 pancreatic cancer cell lines against a panel of 66 small‐molecule kinase inhibitors and dasatinib was the most potent.
W. Chien, Qiao-Yang Sun, K. Lee, Lingwen Ding, P. Wuensche, Lucia A. Torres-Fernández, S. Tan, I. Tokatly, N. Zaiden, L. Poellinger, S. Mori, Henry Yang, J. Tyner, H. Koeffler   +13 more
semanticscholar   +1 more source