Results 61 to 70 of about 2,399,730 (304)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Genome-wide identification and expression analysis of the PP2C gene family in Apocynum venetum and Apocynum hendersonii

BMC Plant Biology
Background Protein phosphatase class 2 C (PP2C) is the largest protein phosphatase family in plants. Members of the PP2C gene family are involved in a variety of physiological pathways in plants, including the abscisic acid signalling pathway, the ...
Jiayi Chen, Yue Wang, Yongmei Wu, Xiaoyu Huang, Xiaojun Qiu, Jikang Chen, Qian Lin, Haohan Zhao, Fengming Chen, Gang Gao   +9 more
doaj   +1 more source

Mutational analysis of the PTPN11 gene in Egyptian patients with Noonan syndrome

Journal of the Formosan Medical Association, 2013
Noonan syndrome (NS) is inherited as an autosomal dominant disorder with dysmorphic facies, short stature, and cardiac defects, which can be caused by missense mutations in the protein tyrosine phosphatase nonreceptor type 11 (PTPN11) gene, which encodes
Mona L. Essawi, Manal F. Ismail, Hanan H. Afifi, Maha M. Kobesiy, Ahmed El Kotoury, Maged M. Barakat   +5 more
doaj   +1 more source

Protein Phosphatase 2A in Lipopolysaccharide-Induced Cyclooxygenase-2 Expression in Murine Lymphatic Endothelial Cells. [PDF]

PLoS ONE, 2015
The lymphatic endothelium plays an important role in the maintenance of tissue fluid homeostasis. It also participates in the pathogenesis of several inflammatory diseases.
Yu-Fan Chuang, Mei-Chieh Chen, Shiu-Wen Huang, Ya-Fen Hsu, George Ou, Yu-Jou Tsai, Ming-Jen Hsu   +6 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Dephosphorylation of the beta 2-adrenergic receptor and rhodopsin by latent phosphatase 2.

Journal of Biological Chemistry, 1988
Recent evidence suggests that the function of receptors coupled to guanine nucleotide regulatory proteins may be controlled by highly specific protein kinases, e.g. rhodopsin kinase and the beta-adrenergic receptor kinase.
S. D. Yang, Y. L. Fong, J. Benovic, D. R. Sibley, M. Caron, R. J. Lefkowitz   +5 more
semanticscholar   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Activation of Aurora-A kinase by protein phosphatase inhibitor-2, a bifunctional signaling protein [PDF]

Proceedings of the National Academy of Sciences, 2004
Aurora-A kinase is necessary for centrosome maturation, for assembly and maintenance of a bipolar spindle, and for proper chromosome segregation during cell division. Aurora-A is an oncogene that is overexpressed in multiple human cancers. Regulation of kinase activity apparently depends on phosphorylation of Thr-288 in the T-loop.
David L, Satinover, Craig A, Leach, P Todd, Stukenberg, David L, Brautigan   +3 more
openaire   +2 more sources

High‐Fat Diet‐Induced Degradation of the Protein Phosphatase 4 Regulatory Subunit 2 Protein Increases Protein Phosphatase 4 Activity in the Aorta and Mediates Endothelial Dysfunction and Vascular Damage

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background High fat diet (HFD)‐induced increases in free fatty acids in the blood increase the risk of cardiovascular diseases by compromising vascular function.
Sha Lv, Zhengwei Liang, Jing Ding, Junshi Zhang, Gang Sun, Xin Chai, Rui Huang, Yazhu Deng, Yong Li, Rongrui Zhang, Ying Xie, Xian Wang, Xueqin Wu, Deqin Lu   +13 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source