Results 61 to 70 of about 625,556 (313)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein Phosphatase 2A in Lipopolysaccharide-Induced Cyclooxygenase-2 Expression in Murine Lymphatic Endothelial Cells. [PDF]

PLoS ONE, 2015
The lymphatic endothelium plays an important role in the maintenance of tissue fluid homeostasis. It also participates in the pathogenesis of several inflammatory diseases.
Yu-Fan Chuang, Mei-Chieh Chen, Shiu-Wen Huang, Ya-Fen Hsu, George Ou, Yu-Jou Tsai, Ming-Jen Hsu   +6 more
doaj   +1 more source

Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2

, 2002
Receptor tyrosine kinases (RTKs) play distinct roles in multiple biological systems. Many RTKs transmit similar signals, raising questions about how specificity is achieved.
Zhang, S., Wen, G., Minichiello, L., Zhang, Si Qing, Wen, Gengyun, Araki, T., Klein, R., Tsiaras, B., Neel, Benjamin G, Neel, B., Araki, Toshiyuki, Klein, Ruediger, Minichiello, Liliana, Tsiaras, William G   +13 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Mutational analysis of the PTPN11 gene in Egyptian patients with Noonan syndrome

Journal of the Formosan Medical Association, 2013
Noonan syndrome (NS) is inherited as an autosomal dominant disorder with dysmorphic facies, short stature, and cardiac defects, which can be caused by missense mutations in the protein tyrosine phosphatase nonreceptor type 11 (PTPN11) gene, which encodes
Mona L. Essawi, Manal F. Ismail, Hanan H. Afifi, Maha M. Kobesiy, Ahmed El Kotoury, Maged M. Barakat   +5 more
doaj   +1 more source

T Cell Protein Tyrosine Phosphatase in Osteoimmunology

Frontiers in Immunology, 2021
Osteoimmunology highlights the two-way communication between bone and immune cells. T cell protein tyrosine phosphatase (TCPTP), also known as protein-tyrosine phosphatase non-receptor 2 (PTPN2), is an intracellular protein tyrosine phosphatase (PTP ...
Ya-nan Wang, Ya-nan Wang, Ya-nan Wang, Shiyue Liu, Shiyue Liu, Shiyue Liu, Tingting Jia, Tingting Jia, Tingting Jia, Yao Feng, Yao Feng, Yao Feng, Wenjing Zhang, Wenjing Zhang, Wenjing Zhang, Xin Xu, Xin Xu, Xin Xu, Dongjiao Zhang, Dongjiao Zhang, Dongjiao Zhang   +20 more
doaj   +1 more source

Activation of Aurora-A kinase by protein phosphatase inhibitor-2, a bifunctional signaling protein [PDF]

Proceedings of the National Academy of Sciences, 2004
Aurora-A kinase is necessary for centrosome maturation, for assembly and maintenance of a bipolar spindle, and for proper chromosome segregation during cell division. Aurora-A is an oncogene that is overexpressed in multiple human cancers. Regulation of kinase activity apparently depends on phosphorylation of Thr-288 in the T-loop.
David L, Satinover, Craig A, Leach, P Todd, Stukenberg, David L, Brautigan   +3 more
openaire   +2 more sources

Identification of a non-purple tartrate-resistant acid phosphatase: An evolutionary link to Ser/Thr protein phosphatases? [PDF]

, 2008
Background: Tartrate-resistant acid phosphatases (TRAcPs), also known as purple acid phosphatases (PAPs), are a family of binuclear metallohydrolases that have been identified in plants, animals and fungi. The human enzyme is a major histochemical marker
David A Hume, Jodie Robinson, Gerhard Schenk, Hadler, K.ieran S., Burrows, Allan, Cassady A Ian, Hadler, K. S., Huber, Thomas, Guddat, L. W., Weber, J., Allan Burrows, Flanagan, J. U., Kelly Gregory, Robinson, J., Schenk Gerhard, Hume David A, Gregory Kelly, Robinson, Jodie, Huber Thomas, Guddat, Luke W., Burrows, A., Hadler, Kieran S., Burrows Allan, A Ian Cassady, Guddat, Luke W, Luke W Guddat, Hume, David A, Hume, D. A., Hume, David A., Kieran S Hadler, Flanagan, Jack U., Weber Jane, Robinson Jodie, Schenk, Gerhard, Kelly, Gregory, Hadler Kieran S, Jack U Flanagan, Jane Weber, Weber, Jane, Cassady, A. Ian, Cassady, A. I., Schenk, G., Guddat Luke W, Flanagan, Jack U, Flanagan Jack U, Huber, T., Hadler, Kieran S, Thomas Huber, Kelly, G., Cassady, Alan Ian   +49 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Genome-wide identification and expression analysis of the PP2C gene family in Apocynum venetum and Apocynum hendersonii

BMC Plant Biology
Background Protein phosphatase class 2 C (PP2C) is the largest protein phosphatase family in plants. Members of the PP2C gene family are involved in a variety of physiological pathways in plants, including the abscisic acid signalling pathway, the ...
Jiayi Chen, Yue Wang, Yongmei Wu, Xiaoyu Huang, Xiaojun Qiu, Jikang Chen, Qian Lin, Haohan Zhao, Fengming Chen, Gang Gao   +9 more
doaj   +1 more source