Results 1 to 10 of about 609,966 (112)

ASPPs multimerize protein phosphatase 1. [PDF]

PLoS Genetics
Protein Phosphatase 1 (PP1) activity is thought to be spatiotemporally defined by hundreds of different regulatory subunits, but their mechanisms of action are largely unknown.
Derek T Wei, Kayleigh N Morrison, Gwendolyn M Beacham, Erika Beyrent, Cyrus A Habas, Ying Zhang, Laurence Florens, Gunther Hollopeter   +7 more
doaj   +2 more sources

Inhibitor-3 inhibits Protein Phosphatase 1 via a metal binding dynamic protein–protein interaction [PDF]

Nature Communications, 2023
Protein phosphatase 1 (PP1) is regulated by intrinsically disordered proteins like inhibitor-3, I3. The authors show that I3 does not inhibit PP1 by forming a rigid complex but instead by binding dynamically with its active site metals, showing how ...
Gautam Srivastava, Meng S. Choy, Nicolas Bolik-Coulon, Rebecca Page, Wolfgang Peti   +4 more
doaj   +2 more sources

Loss of protein phosphatase 1 regulator TIMAP protein triggers EMT in A549 cells [PDF]

Cell Communication and Signaling
Background Epithelial–mesenchymal transition (EMT) is a cellular reprogramming process that enables epithelial cells to acquire mesenchymal traits, leading to enhanced motility, invasiveness, and resistance to therapy.
Fanni Szalmás, Lilla Nagy, Peter Bai, Anita Boratkó   +3 more
doaj   +2 more sources

Mapping the Protein Phosphatase 1 Interactome in Human Cytomegalovirus Infection [PDF]

Viruses
Protein phosphorylation is a crucial regulatory mechanism in cellular homeostasis. The human cytomegalovirus (HCMV) incorporates protein phosphatase 1 (PP1) into its tegument, yet the biological relevance and mechanisms of this incorporation remain ...
Stefan Weinberger, Carmen Stecher, Marie-Theres Kastner, Sergei Nekhai, Christoph Steininger   +4 more
doaj   +2 more sources

PHI-1, an Endogenous Inhibitor Protein for Protein Phosphatase-1 and a Pan-Cancer Marker, Regulates Raf-1 Proteostasis [PDF]

Biomolecules, 2023
Raf-1, a multifunctional kinase, regulates various cellular processes, including cell proliferation, apoptosis, and migration, by phosphorylating MAPK/ERK kinase and interacting with specific kinases.
Jason A. Kirkbride, Garbo Young Nilsson, Jee In Kim, Kosuke Takeya, Yoshinori Tanaka, Hiroshi Tokumitsu, Futoshi Suizu, Masumi Eto   +7 more
doaj   +2 more sources

Protein Phosphatase 1 Regulatory Subunit 3: A Prognostic Biomarker in Stomach Adenocarcinoma [PDF]

International Journal of General Medicine, 2022
Ya-Zhen Zhu,1 Xi-Wen Liao,2 Wu Yin,1 Hai-Ming Wei1 1Department of Pathology, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, People’s Republic of China; 2Department of Hepatobiliary Surgery, The First Affiliated Hospital of ...
Zhu YZ, Liao XW, Yin W, Wei HM
doaj   +2 more sources

PPP1R2 stimulates protein phosphatase-1 through stabilisation of dynamic subunit interactions [PDF]

Nature Communications
Protein Ser/Thr phosphatase PP1 is always associated with one or two regulatory subunits or RIPPOs. One of the earliest evolved RIPPOs is PPP1R2, also known as Inhibitor-2.
Sarah Lemaire, Mónica Ferreira, Zander Claes, Rita Derua, Madryn Lake, Gerd Van der Hoeven, Fabienne Withof, Xinyu Cao, Elora C. Greiner, Arminja N. Kettenbach, Aleyde Van Eynde, Mathieu Bollen   +11 more
doaj   +2 more sources

SDS22 coordinates the assembly of holoenzymes from nascent protein phosphatase-1 [PDF]

Nature Communications
SDS22 forms an inactive complex with nascent protein phosphatase PP1 and Inhibitor-3. SDS22:PP1:Inhibitor-3 is a substrate for the ATPase p97/VCP, which liberates PP1 for binding to canonical regulatory subunits. The exact role of SDS22 in PP1-holoenzyme
Xinyu Cao, Madryn Lake, Gerd Van der Hoeven, Zander Claes, Javier del Pino García, Sarah Lemaire, Elora C. Greiner, Spyridoula Karamanou, Aleyde Van Eynde, Arminja N. Kettenbach, Daniel Natera de Benito, Laura Carrera García, Cristina Hernando Davalillo, Carlos Ortez, Andrés Nascimento, Roser Urreizti, Mathieu Bollen   +16 more
doaj   +2 more sources

Protein phosphatase 1 dephosphorylates profilin-1 at Ser-137. [PDF]

PLoS ONE, 2012
Profilin-1 (PFN1) plays an important role in the control of actin dynamics, and could represent an important therapeutic target in several diseases. We previously identified PFN1 as a huntingtin aggregation inhibitor, and others have implicated it as a ...
Jieya Shao, Marc I Diamond
doaj   +1 more source

CBP Bromodomain Inhibition Rescues Mice From Lethal Sepsis Through Blocking HMGB1-Mediated Inflammatory Responses

Frontiers in Immunology, 2021
CREB binding protein (CBP), a transcriptional coactivator and acetyltransferase, is involved in the pathogenesis of inflammation-related diseases. High mobility group box-1 protein (HMGB1) is a critical mediator of lethal sepsis, which has prompted ...
Xiaowen Bi, Baolin Jiang, Jinyi Zhou, Xirui Fan, Xintong Yan, Juanjuan Liang, Lan Luo, Zhimin Yin   +7 more
doaj   +1 more source