Results 11 to 20 of about 893,184 (294)
Structural basis of protein phosphatase 1 regulation [PDF]
Nature, 2004 The coordinated and reciprocal action of serine/threonine (Ser/Thr) protein kinases and phosphatases produces transient phosphorylation, a fundamental regulatory mechanism for many biological processes. The human genome encodes a far greater number of Ser/Thr protein kinases than of phosphatases.
Terrak, Mohammed +4 more
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SDS22 coordinates the assembly of holoenzymes from nascent protein phosphatase-1 [PDF]
Nature CommunicationsSDS22 forms an inactive complex with nascent protein phosphatase PP1 and Inhibitor-3. SDS22:PP1:Inhibitor-3 is a substrate for the ATPase p97/VCP, which liberates PP1 for binding to canonical regulatory subunits. The exact role of SDS22 in PP1-holoenzyme
Xinyu Cao +16 more
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Protein phosphatase 1 regulatory subunit 15 A promotes translation initiation and induces G2M phase arrest during cuproptosis in cancers [PDF]
Cell Death and DiseaseCopper ions play a crucial role as cofactors for essential enzymes in cellular processes. However, when the intracellular concentration of copper ions exceeds the homeostatic threshold, they become toxic to cells.
Chunyu Liu +8 more
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Circumventing embryonic lethality with Lcmt1 deficiency: generation of hypomorphic Lcmt1 mice with reduced protein phosphatase 2A methyltransferase expression and defects in insulin signaling. [PDF]
, 2013 Protein phosphatase 2A (PP2A), the major serine/threonine phosphatase in eukaryotic cells, is a heterotrimeric protein composed of structural, catalytic, and targeting subunits.
Clarke, Steven G +3 more
core +13 more sources
Regulation of protein phosphatase-1 [PDF]
Chemistry & Biology, 2000 Reversible protein phosphorylation is a major regulatory mechanism of intracellular signal transduction. Protein phosphatase 1 (PP1) is one of four major types of serine-threonine phosphatases mediating signaling pathways, but the means by which its activity is modulated has only recently begun to come into focus.
Aggen, James B +2 more
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Frontiers in Immunology, 2021 CREB binding protein (CBP), a transcriptional coactivator and acetyltransferase, is involved in the pathogenesis of inflammation-related diseases. High mobility group box-1 protein (HMGB1) is a critical mediator of lethal sepsis, which has prompted ...
Xiaowen Bi +7 more
doaj +1 more source
Frontiers in Microbiology, 2021 Human cytomegalovirus (HCMV) carries the human protein phosphatase 1 (PP1) and other human proteins important for protein translation in its tegument layer for a rapid supply upon infection.
Carmen Stecher +8 more
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Protein phosphatase-1 activates CDK9 by dephosphorylating Ser175. [PDF]
PLoS ONE, 2011 The cyclin-dependent kinase CDK9/cyclin T1 induces HIV-1 transcription by phosphorylating the carboxyterminal domain (CTD) of RNA polymerase II (RNAPII).
Tatiana Ammosova +7 more
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Nuclear Protein Phosphatase-1 Regulates HIV-1 Transcription [PDF]
Journal of Biological Chemistry, 2003 We recently reported that protein phosphatase 1 (PP1) dephosphorylates RNA polymerase II C-terminal repeats and regulates HIV-1 transcription in vitro. Here we provide evidence that PP1 is also required for Tat-induced HIV-1 transcription and for viral replication in cultured cells. Inhibition of PP1 by overexpression of nuclear inhibitor of PP1 (NIPP1)
Tatyana, Ammosova +7 more
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Identification of Protein Phosphatase 1 as a Mitotic Lamin Phosphatase [PDF]
Journal of Biological Chemistry, 1997 At the onset of mitosis, the nuclear lamins are hyperphosphorylated leading to nuclear lamina disassembly, a process required for nuclear envelope breakdown and entry into mitosis. Multiple lamin kinases have been identified, including protein kinase C, that mediate mitotic lamin phosphorylation and mitotic nuclear lamina disassembly. Conversely, lamin
L J, Thompson, M, Bollen, A P, Fields
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