Results 11 to 20 of about 629,982 (306)

Protein Phosphatase-1 Regulates Expression of Neuregulin-1 [PDF]

Biology, 2016
Protein phosphatase 1 (PP1), a cellular serine/threonine phosphatase, is targeted to cellular promoters by its major regulatory subunits, PP1 nuclear targeting subunit, nuclear inhibitor of PP1 (NIPP1) and RepoMan.
Tatiana Ammosova, Kareem Washington, Jamie Rotimi, Namita Kumari, Kahli A. Smith, Xiaomei Niu, Marina Jerebtsova, Sergei Nekhai   +7 more
doaj   +3 more sources

Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase-1 in Tat-activated HIV-1 transcription [PDF]

Retrovirology, 2005
Background HIV-1 Tat protein recruits human positive transcription elongation factor P-TEFb, consisting of CDK9 and cyclin T1, to HIV-1 transactivation response (TAR) RNA.
Brady John, Debebe Zufan, Washington Kareem, Ammosova Tatyana, Nekhai Sergei   +4 more
doaj   +3 more sources

Regulation of protein phosphatase-1 [PDF]

Chemistry & Biology, 2000
Reversible protein phosphorylation is a major regulatory mechanism of intracellular signal transduction. Protein phosphatase 1 (PP1) is one of four major types of serine-threonine phosphatases mediating signaling pathways, but the means by which its activity is modulated has only recently begun to come into focus.
Aggen, James B, Nairn, Angus C, Chamberlin, Richard   +2 more
openaire   +2 more sources

Identification of Protein Phosphatase 1 as a Mitotic Lamin Phosphatase [PDF]

Journal of Biological Chemistry, 1997
At the onset of mitosis, the nuclear lamins are hyperphosphorylated leading to nuclear lamina disassembly, a process required for nuclear envelope breakdown and entry into mitosis. Multiple lamin kinases have been identified, including protein kinase C, that mediate mitotic lamin phosphorylation and mitotic nuclear lamina disassembly. Conversely, lamin
L J, Thompson, M, Bollen, A P, Fields
openaire   +2 more sources

Protein Phosphatase 1 Regulates Human Cytomegalovirus Protein Translation by Restraining AMPK Signaling

Frontiers in Microbiology, 2021
Human cytomegalovirus (HCMV) carries the human protein phosphatase 1 (PP1) and other human proteins important for protein translation in its tegument layer for a rapid supply upon infection.
Carmen Stecher, Sanja Marinkov, Lucia Mayr-Harting, Ana Katic, Marie-Theres Kastner, Franz J. J. Rieder-Rommer, Xionghao Lin, Sergei Nekhai, Christoph Steininger   +8 more
doaj   +1 more source

Protein phosphatase-1 activates CDK9 by dephosphorylating Ser175. [PDF]

PLoS ONE, 2011
The cyclin-dependent kinase CDK9/cyclin T1 induces HIV-1 transcription by phosphorylating the carboxyterminal domain (CTD) of RNA polymerase II (RNAPII).
Tatiana Ammosova, Yuri Obukhov, Alexander Kotelkin, Denitra Breuer, Monique Beullens, Victor R Gordeuk, Mathieu Bollen, Sergei Nekhai   +7 more
doaj   +1 more source

The Multifaceted Role of Protein Phosphatase 1 in Plasmodium [PDF]

Trends in Parasitology, 2021
Protein phosphatase type 1 (PP1) forms a wide range of Ser/Thr-specific phosphatase holoenzymes which contain one catalytic subunit (PP1c), present in all eukaryotic cells, associated with variable subunits known as regulatory proteins. It has recently been shown that regulators take a leading role in the organization and the control of PP1 functions ...
Khalife, Jamal, Fréville, Aline, Gnangnon, Bénédicte, Pierrot, Christine   +3 more
openaire   +4 more sources

The nuclear envelope protein, LAP1B, is a novel protein phosphatase 1 substrate. [PDF]

PLoS ONE, 2013
Protein phosphatase 1 (PP1) binding proteins are quintessential regulators, determining substrate specificity and defining subcellular localization and activity of the latter.
Mariana Santos, Sandra Rebelo, Paula J M Van Kleeff, Connie E Kim, William T Dauer, Margarida Fardilha, Odete A da Cruz E Silva, Edgar F da Cruz E Silva   +7 more
doaj   +1 more source

Determinants of the nucleolar targeting of protein phosphatase‐1 [PDF]

FEBS Letters, 2005
The ubiquitously expressed protein Ser/Thr phosphatase‐1 isoforms PP1α, PP1β and PP1γ1 are dynamically targeted to distinct, but overlapping cellular compartments by associated proteins. Within the nucleus of HeLa cells, EGFP‐tagged PP1γ1 and PP1β were predominantly targeted to the nucleoli, while PP1α showed a more diffuse distribution.
Lesage, Bart, Beullens, Monique, Ceulemans, Hugo, Himpens, Bernard, Bollen, Mathieu   +4 more
openaire   +2 more sources

The TriTryp Phosphatome: analysis of the protein phosphatase catalytic domains [PDF]

, 2007
Background The genomes of the three parasitic protozoa Trypanosoma cruzi, Trypanosoma brucei and Leishmania major are the main subject of this study. These parasites are responsible for devastating human diseases known as Chagas disease, African sleeping
Szoor, Balazs; id_orcid, Brenchley Rachel, Matthews Keith, Balázs Szöőr, Stevens Robert, Tabernero, Lydia, McElhinney Helen, Tabernero, Lydia; id_orcid, McElhinney, Helen, Huxley-Jones, Julie, Julie Huxley-Jones, Brenchley, Rachel, Tariq, Humera, Helen McElhinney, Tariq Humera, Keith Matthews, Matthews, Keith; id_orcid, Rachel Brenchley, Szöőr Balázs, Robert Stevens, Tabernero Lydia, Szöor, Balázs, Humera Tariq, Lydia Tabernero, Huxley-Jones Julie, Stevens, Robert, Matthews, Keith   +26 more
core   +1 more source