ASPPs multimerize protein phosphatase 1. [PDF]
PLoS GeneticsProtein Phosphatase 1 (PP1) activity is thought to be spatiotemporally defined by hundreds of different regulatory subunits, but their mechanisms of action are largely unknown.
Derek T Wei +7 more
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Inhibitor-3 inhibits Protein Phosphatase 1 via a metal binding dynamic protein–protein interaction [PDF]
Nature Communications, 2023 Protein phosphatase 1 (PP1) is regulated by intrinsically disordered proteins like inhibitor-3, I3. The authors show that I3 does not inhibit PP1 by forming a rigid complex but instead by binding dynamically with its active site metals, showing how ...
Gautam Srivastava +4 more
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Loss of protein phosphatase 1 regulator TIMAP protein triggers EMT in A549 cells [PDF]
Cell Communication and SignalingBackground Epithelial–mesenchymal transition (EMT) is a cellular reprogramming process that enables epithelial cells to acquire mesenchymal traits, leading to enhanced motility, invasiveness, and resistance to therapy.
Fanni Szalmás +3 more
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Mapping the Protein Phosphatase 1 Interactome in Human Cytomegalovirus Infection [PDF]
VirusesProtein phosphorylation is a crucial regulatory mechanism in cellular homeostasis. The human cytomegalovirus (HCMV) incorporates protein phosphatase 1 (PP1) into its tegument, yet the biological relevance and mechanisms of this incorporation remain ...
Stefan Weinberger +4 more
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Protein Phosphatase-1 Regulates Expression of Neuregulin-1 [PDF]
Biology, 2016 Protein phosphatase 1 (PP1), a cellular serine/threonine phosphatase, is targeted to cellular promoters by its major regulatory subunits, PP1 nuclear targeting subunit, nuclear inhibitor of PP1 (NIPP1) and RepoMan.
Tatiana Ammosova +7 more
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Protein phosphatase-1 inhibitor-2 promotes PP1γ positive regulation of synaptic transmission [PDF]
Frontiers in Synaptic Neuroscience, 2022 Inhibitor-2 (I-2) is a prototypic inhibitor of protein phosphatase-1 (PP1), a major serine-threonine phosphatase that regulates synaptic plasticity and learning and memory.
Karl Foley +15 more
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PHI-1, an Endogenous Inhibitor Protein for Protein Phosphatase-1 and a Pan-Cancer Marker, Regulates Raf-1 Proteostasis [PDF]
Biomolecules, 2023 Raf-1, a multifunctional kinase, regulates various cellular processes, including cell proliferation, apoptosis, and migration, by phosphorylating MAPK/ERK kinase and interacting with specific kinases.
Jason A. Kirkbride +7 more
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Protein phosphatase 1 regulates core PCP signaling. [PDF]
EMBO Rep, 2023 Abstract PCP signaling polarizes epithelial cells within the plane of an epithelium. Core PCP signaling components adopt asymmetric subcellular localizations within cells to both polarize and coordinate polarity between cells.
Song S +13 more
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Modulation of dendritic spines by protein phosphatase-1. [PDF]
Adv Pharmacol, 2021 Protein phosphatase-1 (PP-1), a highly conserved multifunctional serine/threonine phosphatase, is enriched in dendritic spines where it plays a major role in modulating excitatory synaptic activity. In addition to established functions in spine maturation and development, multi-subunit holoenzyme forms of PP-1 modulate higher-order cognitive functions ...
Platholi J, Hemmings HC.
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Protein Phosphatase 1 Regulatory Subunit 3: A Prognostic Biomarker in Stomach Adenocarcinoma [PDF]
International Journal of General Medicine, 2022 Ya-Zhen Zhu,1 Xi-Wen Liao,2 Wu Yin,1 Hai-Ming Wei1 1Department of Pathology, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, People’s Republic of China; 2Department of Hepatobiliary Surgery, The First Affiliated Hospital of ...
Zhu YZ, Liao XW, Yin W, Wei HM
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