Results 41 to 50 of about 1,444,803 (306)

Protein tyrosine phosphatase 1 protects human pancreatic cancer from erastin-induced ferroptosis

Asian Journal of Surgery, 2022
Background: Pancreatic ductal adenocarcinoma (PDAC) is a fatal malignancy due to the lack of early detection method, therapeutic drug and target. We noticed that the expression of Protein Tyrosine Phosphatase Mitochondria1(PTPMT1) is upregulated in PDAC.
Xiao-Dong Huang, PhD, Feng-Jun Xiao, PhD, Yu-Tong Guo, Yang Sun, Yi-Kun Zhang, PhD, Xian-Jie Shi, PhD   +5 more
doaj   +1 more source

Plasmodium berghei leucine-rich repeat protein 1 downregulates protein phosphatase 1 activity and is required for efficient oocyst development

Open Biology, 2022
Protein phosphatase 1 (PP1) is a key enzyme for Plasmodium development. However, the detailed mechanisms underlying its regulation remain to be deciphered.
Aline Fréville, Bénédicte Gnangnon, Annie Z. Tremp, Caroline De Witte, Katia Cailliau, Alain Martoriati, El Moukthar Aliouat, Priyanka Fernandes, Cerina Chhuon, Olivier Silvie, Sabrina Marion, Ida Chiara Guerrera, Johannes T. Dessens, Christine Pierrot, Jamal Khalife   +14 more
doaj   +1 more source

MAPK phosphatase-1 represents a novel antiinflammatory target of glucocorticoids in the human endothelium [PDF]

, 2007
Glucocorticoids are well-established anti- inflammatory drugs thought to mainly act by inhibition of proinflammatory transcription factors like NF-κB.
Timm Schroeder, Stefan Zahler, Eilken, H.M., Bubik, M.F., Vollmar, Angelika M., Alexandra K. Kiemer, Kiemer, Alexandra K., Zahler, S., Fürst, Robert, Robert Fürst, Schroeder, Timm, Martin F. Bubik, Angelika M. Vollmar, Hanna M. Eilken, Vollmar, A.M., Eilken, Hanna M., Fürst, R., Bubik, Martin F., Zahler, Stefan, Schroeder, T., Kiemer, A.K.   +20 more
core   +1 more source

The function of the protein phosphatase Glc7p in transcription termination, RNA processing and transcriptional regulation of ribosomal protein genes [PDF]

, 2007
Gene transcription in general can be subdivided into three main phases: transcription initiation, elongation and termination. The enzyme that accomplishes transcription of protein coding genes, snRNAs and snoRNAs is RNA polymerase II (RNAP II).
Röck, Salome
core   +1 more source

STABILITY AND CATALYTIC EFFICIENCY OF THE ENZYMES IMMOBILIZED ON NATURAL AND SYNTHETIC ORGANO-CLAY COMPLEXES [PDF]

Journal of Soil Sciences and Agricultural Engineering, 2008
This investigation was conducted on soil samples collected from different fluvial and lacustrine depositional environments, irrigated for a long-time with either Nile water or wastewaters.
M.A.M. El-Kammah
doaj   +1 more source

The serine-threonine protein phosphatases that regulate the thiazide-sensitive NaCl cotransporter

Frontiers in Physiology, 2023
The activity of the Na+-Cl- cotransporter (NCC) in the distal convoluted tubule (DCT) is finely tuned by phosphorylation networks involving serine/threonine kinases and phosphatases.
Héctor Carbajal-Contreras, Héctor Carbajal-Contreras, Gerardo Gamba, Gerardo Gamba, Gerardo Gamba, María Castañeda-Bueno   +5 more
doaj   +1 more source

A unique kelch domain phosphatase in plasmodium regulates ookinete morphology, motility and invasion [PDF]

, 2012
Signalling through post-translational modification (PTM) of proteins is a process central to cell homeostasis, development and responses to external stimuli.
Heli J. Vaikkinen (137832), Nisha Philip (137829), Laurence Tetley, Tetley, L., Waters, A.P., Vaikkinen, Heli J, Tetley, Laurence, Waters, Andrew P., Nisha Philip, Vaikkinen, H.J., Andrew P. Waters (15293), Laurence Tetley (37791), Heli J Vaikkinen, Philip, N., Philip, Nisha, Andrew P Waters   +15 more
core   +1 more source

Protein Phosphatase 1 δ is Associated with Focal Adhesions [PDF]

Cell Adhesion and Communication, 1998
In all mammalian cells protein phosphatase-1 (PP1) exists in three isoforms, defined as alpha, gamma 1 and delta. Immunofluorescence studies with isoform-specific antibodies indicated that delta, but not alpha or gamma 1, is enriched at focal adhesions in HeLa cells, fibroblasts, endothelial cells and keratinocytes.
VILLA, EMMA, TOGNARINI M., CECCHINI G., MARCHISIO P. C.   +3 more
openaire   +3 more sources

Over-expression of MAP kinase phosphatase-2 enhances adhesion molecule expression and protects against apoptosis in human endothelial cells [PDF]

, 2010
In this study we used adenovirus infection to overexpress the dual specific phosphatase, MAP kinase phosphatase-2 (MKP-2), in human umbilical vein endothelial cells and examined inflammatory protein expression and apoptosis, two key features of ...
Mashael Al-Mutairi, Cadalbert, Laurence, Plevin, Robin, Robin Plevin, Laurence Cadalbert, Sameer Al-Harthi, Al-Harthi, Sameer, Al-Mutairi, Mashael, Plevin, R.J.   +8 more
core   +1 more source

Identification of a protein phosphatase-1/phospholamban complex that is regulated by cAMP-dependent phosphorylation.

PLoS ONE, 2013
In human and experimental heart failure, the activity of the type 1 phosphatase is significantly increased, associated with dephosphorylation of phospholamban, inhibition of the sarco(endo)plasmic reticulum Ca(2+) transport ATPase (SERCA2a) and depressed
Elizabeth Vafiadaki, Demetrios A Arvanitis, Despina Sanoudou, Evangelia G Kranias   +3 more
doaj   +1 more source